1988
DOI: 10.1016/0049-3848(88)90137-5
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Platelet functional changes secondary to hepatocholestasis and elevation of serum bile acids

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Cited by 15 publications
(14 citation statements)
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“…This result agrees with previous data (Bowen et al, 1988; Shiao et al, 1993) but disagrees with those of McGregor (McGregor et al, 1980) showing that cholic acid increased thrombin and ADP-induced platelet aggregation and accelerated plasma clotting time. A similar result was obtained in fibroblasts, where DCA directly induced both Ca 2+ release from internal stores and persistent entry at the plasma membrane (Lau et al, 2005).…”
Section: Discussionsupporting
confidence: 78%
See 1 more Smart Citation
“…This result agrees with previous data (Bowen et al, 1988; Shiao et al, 1993) but disagrees with those of McGregor (McGregor et al, 1980) showing that cholic acid increased thrombin and ADP-induced platelet aggregation and accelerated plasma clotting time. A similar result was obtained in fibroblasts, where DCA directly induced both Ca 2+ release from internal stores and persistent entry at the plasma membrane (Lau et al, 2005).…”
Section: Discussionsupporting
confidence: 78%
“…The underlying mechanisms for altered platelet function in cholestasis are unclear. Several mechanisms have been suggested (Bowen et al, 1988; Pihusch et al, 2002; Atucha et al, 2007; Witters et al, 2010; Tripodi et al, 2011), including an intrinsic change in platelet function, e.g., increased aggregation resulting from altered intracellular calcium (Ca 2+ ) homeostasis or decreased aggregation due to a storage pool deficiency, the effect of a plasmatic factor such as bile acids or bilirubin or because of the effect of release of ADP-degrading enzymes in the circulation. Regarding platelet activation, the necessary increase in cytoplasmic Ca 2+ levels, both by release from internal stores and entry of extracellular Ca 2+ , has been reported to be defective both in experimental models of liver cirrhosis and patients (Bandi et al, 1997; Atucha et al, 2007; Annie-Jeyachristy et al, 2008).…”
Section: Introductionmentioning
confidence: 99%
“…In addition, the concentration of bile salts generally increases in hepatic failure ( 33) and can be up to 40 times higher than in healthy patients ( 8, 32). In patients with elevated bile acid levels in plasma, several problems arise including impaired coagulation ( 34) and platelet function( 35), and altered ion transport in red blood cells ( 36).…”
Section: Discussionmentioning
confidence: 99%
“…However, not all reports are equivocal with regard to platelet hyperaggregability, which could not be demonstrated by platelet aggregometry in either patients [7] or animal models [8–10]. Moreover, there is a prolonged bleeding time [8] and a loss of releasable ATP [7], as well as reduced expression of CD62P, after platelet stimulation [4]; all of these are indicative of decreased platelet function.…”
Section: Introductionmentioning
confidence: 99%
“…increased aggregation resulting from altered Ca 2+ homeostasis [6] or decreased aggregation due to a storage pool deficiency [7]), or the effect of a plasmatic factor (e.g. inhibition by bile acids [10], or stimulation by bilirubin [10]).…”
Section: Introductionmentioning
confidence: 99%