Platelet function in septic multiple organ dysfunction syndrome

Gawaz, Meinrad; Dickfeld, Timm; Bogner, Christian; Fateh-Moghadam, Suzanne; Neumann, Franz‐Josef

doi:10.1007/s001340050344

Cited by 203 publications

(188 citation statements)

References 30 publications

(35 reference statements)

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“…Additionally, septic platelet activation can facilitate the production of both pro-and antiinflammatory cytokine networks (26). The nature of this platelet activation is characterized by increased surface Pselectin expression (27,28); increased levels of a granulereleased factors in plasma, such as soluble P-selectin (29); and increased levels of triggering receptor expressed on myeloid cells-like transcript-1 (30) or PF-4 in mice (31). Clark et al (6) also showed a novel mechanism of platelet-neutrophil interaction that leads to enhanced bacterial trapping during sepsis.…”

Section: Platelets and Pathogensmentioning

confidence: 99%

Nouvelle Cuisine: Platelets Served with Inflammation

Kapur

Zufferey

Boilard

et al. 2015

The Journal of Immunology

177

191

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Platelets are small cellular fragments with the primary physiological role of maintaining hemostasis. In addition to this well-described classical function, it is becoming increasingly clear that platelets have an intimate connection with infection and inflammation. This stems from several platelet characteristics, including their ability to bind infectious agents and secrete many immunomodulatory cytokines and chemokines, as well as their expression of receptors for various immune effector and regulatory functions, such as TLRs, which allow them to sense pathogen-associated molecular patterns. Furthermore, platelets contain RNA that can be nascently translated under different environmental stresses, and they are able to release membrane microparticles that can transport inflammatory cargo to inflammatory cells. Interestingly, acute infections can also result in platelet breakdown and thrombocytopenia. This report highlights these relatively new aspects of platelets and, thus, their nonhemostatic nature in an inflammatory setting.

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Section: Platelets and Pathogensmentioning

confidence: 99%

Nouvelle Cuisine: Platelets Served with Inflammation

Kapur

Zufferey

Boilard

et al. 2015

The Journal of Immunology

177

191

View full text Add to dashboard Cite

show abstract

“…Several studies have shown that platelet counts and function are reduced in patients with severe sepsis and septic shock (9)(10)(11). Moreover, platelet indices, such as mean platelet volume (MPV) and platelet distribution width (PDW), have been associated with these conditions (12,13).…”

Section: Introductionmentioning

confidence: 99%

Platelet Indices as Predictive Markers of Prognosis in Pediatric Septic Shock Patients

Choi

Jhang

et al. 2017

Iran J Pediatr

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“…By using different animal models, studies have shown the indispensable role of platelets in the initiation and progression of inflammatory and autoimmune diseases, including sepsis, 12 atherosclerosis, 13 autoimmune myocarditis, 14 systemic lupus erythematosus, 15 rheumatoid arthritis [16][17][18][19] and so on. Allergic asthma is a chronic inflammatory pathological condition with critical involvement of T helper 2 (Th2) cells that is harmful to human health throughout the world.…”

Section: Introductionmentioning

confidence: 99%

Platelets promote allergic asthma through the expression of CD154

et al. 2014

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Platelet activation is associated with multiple immune responses and the pathogenesis of various immune-related diseases. However, the exact role and the underlying mechanism of platelets in the progression of allergic asthma remain largely unclear. In this study, we demonstrate that during antigen sensitization, platelets can be activated by ovalbumin (OVA) aerosol via the upregulation of CD154 (CD40L) expression. Platelet transfer promoted allergic asthma progression by inducing more severe leukocyte infiltration and lung inflammation, elevated IgE production and strengthened T helper 2 (Th2) responses in asthma-induced mice. Accordingly, platelet depletion compromised allergic asthma progression. Cd154-deficient platelets failed to promote asthma development, indicating the requirement of CD154 for platelets to promote asthma progression. The mechanistic study showed that platelets inhibited the induction of Foxp3 1 regulatory T cells both in vivo and in vitro at least partially through CD154, providing an explanation for the increase of Th2 responses by platelet transfer. Our study reveals the previously unknown role of platelet CD154 in the promotion of asthma progression by polarizing Th2 responses and inhibiting regulatory T-cell generation and thus provides a potential clue for allergic disease interventions.

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Platelet function in septic multiple organ dysfunction syndrome

Abstract: In septic patients platelets become activated and are hyperadhesive to other vascular cells including neutrophils and endothelium. This may induce sequestration of platelets and microcirculatory arrest, thus the development of MODS.

Cited by 203 publications

References 30 publications

Nouvelle Cuisine: Platelets Served with Inflammation

Nouvelle Cuisine: Platelets Served with Inflammation

Platelet Indices as Predictive Markers of Prognosis in Pediatric Septic Shock Patients

Platelets promote allergic asthma through the expression of CD154

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