Platelet function in pregnant women receiving aspirin and dipyridamole

Abstract

At the doses used in this study, aspirin and dipyridamole inhibited platelet aggregation for up to 3 days after cessation of medication. This abnormality of aggregation was not detected by the bleeding time and was not associated with clinically abnormal bleeding.

Neuraxial anesthesia in obstetric patients receiving anticoagulant and antithrombotic drugs

“…41 Kinouchi et al observed that ADP-induced platelet aggregation was decreased in pregnant patients receiving antiplatelet therapy (aspirin 40 mg/day + dipyridamole 150 mg/day), but remained within normal range; prothrombin times and PTT values were also not prolonged. 42 In the majority of cases, no special precautions are required for performing neuraxial anesthesia in patients receiving aspirin ( Table 2).…”

Anticoagulant and antithrombotic drugs in pregnancy: what are the anesthetic implications for labor and cesarean delivery?

“…Adequate in vivo hemostasis as measured by thromboelastography has been reported in pregnant patients after aspirin ingestion (600 mg). 66 Kinouchi et al 67 found that ADP-induced platelet aggregation was decreased in pregnant patients receiving antiplatelet therapy (aspirin 40 mg per day þ dipyridamole 150 mg per day), but remained within a normal range; prothrombin time and APTT values were also not prolonged.…”