Platelet FcIgG receptior: Increased expression in female platelets

Moore, A. Ulric; Weksler, Babette B.; Nachman, Ralph L.

doi:10.1016/0049-3848(81)90147-x

Cited by 9 publications

(3 citation statements)

References 12 publications

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“…SERA 10-20 ml of venous blood was drawn from each subject, placed in 10 ml sterile plain tubes, and allowed to clot at 37°C for two hours. After centrifugation at 1500 g for 10 minutes serum was isolated, recentrifuged at 1500 g for 10 Suspensions of washed human platelets were prepared as described by Medcalf et al7 50 ml of blood was drawn from the antecubital vein through a 19 gauge needle into acid citrate dextrose (ACD) in a polypropylene syringe. The final ACD/blood ratio was 1/6.…”

Section: Materials and Methods Patients And Control Groupsmentioning

confidence: 99%

Platelet releasing activity in sera of patients with rheumatoid vasculitis.

Cunningham

Medcalf

Mathews

et al. 1986

Annals of the Rheumatic Diseases

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SUMMARY Platelet releasing activity was found in sera fractionated by 30% ammonium sulphate in seven of 11 patients with systemic rheumatoid vasculitis, two of 16 patients with cutaneous rheumatoid vasculitis, and three of 18 patients with clinically uncomplicated rheumatoid arthritis. Serial studies in three patients suggest a key role of platelet activation by serum factors in the pathogenesis of systemic rheumatoid vasculitis. IgG rheumatoid factor or IgG containing immune complexes, or both, may be responsible for this platelet releasing activity.

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Section: Materials and Methods Patients And Control Groupsmentioning

confidence: 99%

Platelet releasing activity in sera of patients with rheumatoid vasculitis.

Cunningham

Medcalf

Mathews

et al. 1986

Annals of the Rheumatic Diseases

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“…Platelet antibodies may trigger platelet activation by FcγRs and thus mediate more efficient clearance of platelets from the circulation. That platelets from females when stimulated by heat-aggregated IgG, released significantly more serotonin than platelets from males (Moore et al, 1981), has been suggested to imply either increased amounts of Fcγ receptors on platelets or more sensitivity to FcγR-induced platelet stimulation. Expression of FcγRs also varies on phagocytoses.…”

Section: Genetic Polymorphism Of Platelet Fcγriia In Thrombocytopeniamentioning

confidence: 99%

Autoimmune Thrombocytopenia

Kickler

2006

Manual of Molecular and Clinical Lab Immunology

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“…determination, and without complications, were selected for this study to minimize interfering factors on thromboxane synthesis due to age, 14 sex and hormone-influence, 15 hyperglycemia, 16 and angiopathy. 9…”

mentioning

confidence: 99%