Platelet-endothelial cell adhesion molecule-1 gene polymorphism and its soluble level are associated with severe coronary artery stenosis in Chinese Singaporean

Leucine125Valine (Leu125Val) Gene Polymorphism of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Myocardial Infarction in Indian Population

“…Wenzel et al [10] have reported allele frequencies of the Leu125/ Val125 in German population as 0.49/0.51 in controls and 0.35/0.65 in CAD patients reporting increased Val125 allele in CAD patients (P \ 0.01). Among Asian population strong association with CAD of Leu125Val polymorphism has been noted down by Song et al [15] and Wei et al [16] in Chinese population. Against these reports Gardemann et al [11] in German population and Elrayees et al [12] in British population did not find Leu125Val gene polymorphism of PECAM-1 as an independent risk factor of CAD.…”

“…Wei et al [16] have reported elevated levels of sPECAM-1 associated with subjects with Val125Val genotype in Chinese population of Singapore while Fang et al [17] have reported no effect of the genotype on the soluble levels in Asian Indians (South Indians) of Singapore. While analyzing the influence of PECAM-1 genotype on soluble levels of PE-CAM-1 within each group in the present study, there were increased levels associated with patients of Val125Val genotype of MI-Group-1 as compared to other two genotypes.…”

“…PECAM-1 is a 130-kDa trans-membrane glycoprotein. It has 6 Ig-like extracellular domains (encoded by exon 3-8) a short trans-membrane domain (encoded by exon 9) and a short cytoplasmic tail (encoded by exon [10][11][12][13][14][15][16] [6,7]. The importance of the first domain of PECAM-1 (encoded by exon 3) is underscored since PECAM-1 forms homophilic binding via its 1st or 1st plus 2nd extracellular Ig-like domains or heterophilic binding with other molecules to mediate cell-cell adhesion [3,8].…”

“…Association between Leu125Val PECAM-1 polymorphism and CAD have been analysed in Caucasians [10][11][12][13], Japanese [14], Chinese [15,16] and Asian Indian residents of Singapore [17]. Although studies discussed so far seem to suggest conflicting data, those investigating the association of PECAM-1 polymorphism and risk of atherogenesis always show increased risk with 125Val [10,[15][16][17] and association of PECAM-1 polymorphism and risk of MI show increased risk with 125Leu [14].…”

“…Although studies discussed so far seem to suggest conflicting data, those investigating the association of PECAM-1 polymorphism and risk of atherogenesis always show increased risk with 125Val [10,[15][16][17] and association of PECAM-1 polymorphism and risk of MI show increased risk with 125Leu [14]. This is thought to be due to different effects of polymorphisms in PECAM-1.…”