Platelet Disorders in the Adolescent Female

Warad, Deepti; Chitlur, Meera; Philipp, Claire S.

doi:10.1007/978-3-030-48446-0_6

Cited by 2 publications

(1 citation statement)

References 82 publications

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“…Treatment is based upon general management recommendations for HMB as mentioned in GT patients. It is recommended that those people should be managed by specialists and multidisciplinary teams to ensure optimum treatment [54]. The 2020 systematic review mentioned above included 14 BSS patients from case reports and case series and their therapeutic interventions are summarized on Table 4.…”

Section: Treatment Options For Hmbmentioning

confidence: 99%

Primary Hemostasis Disorders as a Cause of Heavy Menstrual Bleeding in Women of Reproductive Age

Kontogiannis,

Matsas,

Valsami

et al. 2023

JCM

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Heavy menstrual bleeding (HMB) is a common clinical condition affecting adolescent and adult women and compromising their quality of life. Primary hemostasis disorders, affecting platelet plug formation, can be the underlying cause of HMB. They comprise a heterogeneous group of diseases with Von Willebrand disease (VWD) being the most commonly diagnosed; other disorders in this group that have been linked to HMB include (a) Glanzmann thrombasthenia, (b) Bernard–Soulier syndrome, (c) Hermansky–Pudlak syndrome, (d) immune thrombocytopenia (ITP), and (e) Ehlers–Danlos syndromes (EDS) and hypermobility spectrum disorders (HSD). Diagnosing these diseases can be challenging, as the basic laboratory investigations can be within the normal range. Thus, identification of specific clinical features and a thorough hematologic workup can be very important, providing the correct diagnosis. Proper diagnosis of the underlying disorder is important, as management may vary accordingly. Although disease-specific management guidelines exist for some of these disorders such as VWD and ITP, due to the rarity of most primary hemostasis disorders, the best approach for the management of HMB in these women remains elusive. The goal of this study was to create an informative, comprehensive review of the primary hemostasis disorders that have been linked to HMB. This study provides a summary of the basic published information regarding epidemiology, pathophysiology, clinical phenotype, diagnosis, and treatment of HMB in those diseases and serves as a reference guide for further reading.

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Section: Treatment Options For Hmbmentioning

confidence: 99%

Primary Hemostasis Disorders as a Cause of Heavy Menstrual Bleeding in Women of Reproductive Age

Kontogiannis,

Matsas,

Valsami

et al. 2023

JCM

View full text Add to dashboard Cite

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Diagnosis and management of abnormal uterine bleeding in adolescence

Santi,

Fulghesu,

Zanon

et al. 2024

Bleed Thromb Vascul Biol

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During menarche and adolescence, abnormal uterine bleeding (AUB) may serve as a crucial indicator of a hidden bleeding disorder. When a young woman is suspected of having a bleeding disorder, the obstetrician-gynecologist should collaborate with a hemostasis specialist to arrange the necessary laboratory testing and determine the best course of action. The Italian Society for the Study of Hemostasis and Thrombosis and the Italian Society of Gynecology and Obstetrics jointly offer recommendations on the diagnosis and treatment of AUB. They also suggest diagnostic and therapeutic pathways to decrease diagnostic delay and improve treatment effectiveness and safety.

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Platelet Disorders in the Adolescent Female

Cited by 2 publications

References 82 publications

Primary Hemostasis Disorders as a Cause of Heavy Menstrual Bleeding in Women of Reproductive Age

Primary Hemostasis Disorders as a Cause of Heavy Menstrual Bleeding in Women of Reproductive Age

Diagnosis and management of abnormal uterine bleeding in adolescence

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