Platelet Disorders in Adolescents

Philipp, Claire S.

doi:10.1016/j.jpag.2010.08.012

Cited by 14 publications

(2 citation statements)

References 35 publications

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“…Our findings were not in agreement with that [16]. The PFD was seen 18.1 % of adolescents with menorrhagia in our case cohort, while VWD was seen in 45.4 %.…”

Section: Discussioncontrasting

confidence: 99%

Evaluation of the Hemostatic Disorders in Adolescent Girls with Menorrhagia: Experiences from a Tertiary Referral Hospital

Karaman

Ceylan

Karaman

et al. 2015

Indian J Hematol Blood Transfus

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Bleeding disorders are a common cause of menorrhagia in the adolescent age group. We aimed to evaluate the incidence of hemostatic disorders, using clinical and laboratory findings of bleeding disorders in adolescent girls with menorrhagia. A retrospective chart review used to evaluate adolescent girls with menorrhagia who were referred to Yuzuncu Yil University Pediatric Hematology clinic between January 2010 and December 2014. Out of 52 patients referred for investigation, 50 patients were included in the study. The mean age and mean menarche age were 14.8 ± 1.42 (range: 12-17) and 12.47 ± 0.55, respectively. In 42 % (n = 21) of patients, anemia was detected. In 22 % (n = 11) of patients, a bleeding disorder was detected: five cases with von Willebrand disease, two cases with acute immune thrombocytopenic purpura, one case with BernardSoulier syndrome, one case with Glanzmann thrombasthenia, one case with aplastic anemia and one case with factor X deficiency. The remaining 39 out of the 50 patients were finally diagnosed with dysfunctional uterine bleeding. When compared the patients with bleeding disorders and without bleeding disorders, bleeding from other sites, including gingival bleeding or epistaxis, low platelet counts and prolonged activated partial thromboplastin time were found statistically more frequent in patients with bleeding disorders (p \ 0.05). Menorrhagia in adolescents is frequently associated with underlying bleeding disorders. Adolescents with heavy menstrual bleeding and a history of nose or gingival bleeding should be evaluated for congenital bleeding disorders.

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“…Our findings were not in agreement with that [16]. The PFD was seen 18.1 % of adolescents with menorrhagia in our case cohort, while VWD was seen in 45.4 %.…”

Section: Discussioncontrasting

confidence: 99%

Evaluation of the Hemostatic Disorders in Adolescent Girls with Menorrhagia: Experiences from a Tertiary Referral Hospital

Karaman

Ceylan

Karaman

et al. 2015

Indian J Hematol Blood Transfus

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show abstract

“…In concordance, Gursel et al [2] in 2014 found that vWD was the commonest bleeding disorder among Turkish adolescent girls with menorrhagia followed by PFDs and clotting factor deficiency (6.5, 5.2, and 2.6% respectively). Although vWD was the commonest bleeding disorder among adolescents with menorrhagia in many studies followed by platelet disorders and clotting factor deficiency [2,30], other studies stated that PFDs were observed more commonly than vWD in women with menorrhagia [33,34]. Immune thrombocytopenia (ITP) was also reported as an underlying cause of heavy menstrual bleeding second to vWD in Turkish adolescent girls (45.4%, 5/11 and 18.1%.…”

Section: Discussionmentioning

confidence: 99%

Screening hemostatic defects in Saudi University students with unexplained menorrhagia: a diagnosis, which could be missed

Bakr

Almutairi

Dawalibi

et al. 2021

Blood Coagulation &Amp; Fibrinolysis

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Bleeding disorders are a common cause of unexplained menorrhagia in adolescents. However, there is lack of information provided on Arab girls. To estimate the prevalence of coagulation factor deficiencies and platelet dysfunction among Saudi university students with unexplained menorrhagia. In this cross sectional study, 463 adolescent girls surveyed for having heavy menses for further evaluation of underlying bleeding tendencies using screening standardized questionnaire. Only 109 girls out of the total 463 girls reported menorrhagia and were included in the evaluation. All girls with menorrhagia were evaluated by Pictorial blood assessment chart (PBAC) for precise evaluation of menstrual blood loss (PBAC score >100), had underwent pelvic ultrasonography and screening of hemostatic abnormalities (complete blood count, PFA-100, PT, aPTT, vWF:RCo, vWF:Ag, coagulation factors assay). On the basis of the score of PBAC more than 100, 25.6% (28/109) of adolescent women (age ranged: 17–25 years old) had confirmed menorrhagia. In 30.8% of them, an ultimate diagnosis of bleeding tendency or hemostatic abnormality was detected [five cases of probable von Willebrand disease (vWD) or low level of vWF:Ag and/or vWF:RCo, two cases of probable platelet dysfunction, and one case of factorV (FV) deficiency]. Anemia was found in 39.28% (11/28) of them; however, only 4 (36%) had received iron supplements. Our study demonstrated that hemostatic defects are not uncommon in Saudi adolescent women presenting with menorrhagia but mostly unrecognized and untreated. It is probably advisable to screen women with menorrhagia for these defects.

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Non-surgical interventions for treating heavy menstrual bleeding (menorrhagia) in women with bleeding disorders

Ray¹,

Ray²,

George³

2013

Cochrane Database of Systematic Reviews

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Platelet Disorders in Adolescents

Cited by 14 publications

References 35 publications

Evaluation of the Hemostatic Disorders in Adolescent Girls with Menorrhagia: Experiences from a Tertiary Referral Hospital

Evaluation of the Hemostatic Disorders in Adolescent Girls with Menorrhagia: Experiences from a Tertiary Referral Hospital

Screening hemostatic defects in Saudi University students with unexplained menorrhagia: a diagnosis, which could be missed

Non-surgical interventions for treating heavy menstrual bleeding (menorrhagia) in women with bleeding disorders

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