Platelet-Derived Microparticles: A New Index of Monitoring Platelet Activation and Inflammation in Kawasaki Disease

Jin, Jing; Wang, Jing; Lu, Yinan; Fan, Zhidan; Huang, Na; Ma, Le; Yu, Haiguo

doi:10.1007/s12098-018-2765-2

Cited by 24 publications

(13 citation statements)

References 32 publications

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“…However, our study unexpectedly observed that ADP in the defervescence period of KD was slightly prolonged compared with that in the febrile period of KD or that in the defervescence period of the febrile control group. Except for other factors, such as the reduced hematocrit or platelet count 25 , it indicates that IVIG can inhibit platelet activation in KD patients, as reported in previous studies 26,27 .…”

Section: Discussionsupporting

confidence: 60%

Changes in and significance of platelet function and parameters in Kawasaki disease

Zheng

Zhang

et al. 2019

Sci Rep

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Kawasaki disease (KD) is a systemic febrile, inflammatory vascular disease of unknown etiology. The coronary artery abnormality (CAA) caused by KD has become the most commonly acquired heart disease in children. Initial treatment of intravenous immunoglobulin (IVIG) can reduce the incidence of CAA. Thrombocytosis is common during the course of KD, but changes in and significances of platelet function and parameters are unclear. In this study, we enrolled 120 patients, including 40 patients with KD, 40 febrile controls, and 40 afebrile controls. The platelet function was assessed using the platelet function analyzer (PFA)-200. Platelet parameters, including platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet hematocrit (PCT) were measured. In the febrile period, the PDW and MPV were lower in KD patients (P < 0.05). The platelet function did not change significantly during the febrile period of KD but weakened in the defervescence phase. No significant differences between the CAA and normal groups, and between IVIG resistance and response groups. The diagnostic cutoff value of the PDW level for predicting KD was 10.85 fL with a sensitivity of 55% and a specificity of 77.5% (area under curve (AUC) = 0.690, 95% confidence interval (CI): 0.574–0.806, P < 0.01). Besides, the MPV level was 9.55 fL with sensitivity of 75% and specificity of 70% (AUC = 0.733, 95%CI: 0.620–0.846, P < 0.001). This is the first longitudinal study of platelet function changes in KD patients using PFA-200. Besides, lower PDW and MPV may be available markers for early diagnosis of KD.

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Section: Discussionsupporting

confidence: 60%

Changes in and significance of platelet function and parameters in Kawasaki disease

Zheng

Zhang

et al. 2019

Sci Rep

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“…On the other hand, the activation of platelets can be found in the pathophysiological changes in many biological processes, that is, infection, inflammation, and tumorigenesis. In the case of inflammation, platelets were rapidly recruited and participated in the pathogenesis of inflammation by secreting cytokines, chemokines, and other inflammatory mediators; however, the relationship between the platelet and HCA has not yet been reported. Interestingly, in our study, we observed that the platelet count of the patients was significantly increased in HCA group compared with the control group ( P < 0.001), and the platelet count in HCA group was significantly higher than in non‐HCA group ( P < 0.001); moreover, receiver operating characteristic curve has been drawn to evaluate the diagnostic value of PLT/WBC to distinguish HCA patients from non‐HCA patients.…”

Section: Discussionmentioning

confidence: 99%

Maternal peripheral blood platelet‐to‐white blood cell ratio and platelet count as potential diagnostic markers of histological chorioamnionitis‐related spontaneous preterm birth

Li-yin

Pan

Rong-lian

et al. 2019

Clinical Laboratory Analysis

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Background Histological chorioamnionitis (HCA) is one of the leading causes of spontaneous preterm birth, thus, to identify novel biomarkers for the early diagnosis of HCA is in a great need. Objective To investigate the diagnostic value of maternal peripheral blood platelet‐to‐white blood cell ratio (PLT/WBC) and platelet (PLT) counts in HCA‐related preterm birth. Methods A total of 400 patients with preterm birth were enrolled in this study: non‐HCA group (n = 193) and HCA group (n = 207), and 87 full‐term pregnancies were enrolled as the control. The peripheral blood of the participators was collected, and the neutrophil count, WBC count, platelet count, and levels of C‐reactive protein (CRP) and procalcitonin were recorded, and the platelet‐to‐white blood cell ratio (PLT/WBC) of the participators was calculated. Receiver operating characteristic (ROC) curve has been drawn to show the sensitivity and specificity of PLT/WBC and PLT count for the diagnosis of HCA‐related spontaneous preterm birth patients. Results The neutrophil count, WBC count, and procalcitonin show no significant differences among the three groups, and the PLT count, PLT/WBC, and CRP (P < 0.05) were significantly increased in HCA group compared with non‐HCA group; moreover, the area under the curve (AUC) of PLT/WBC, PLT, and CRP was 0.744 (95% confidence interval [CI], 0.6966‐0.7922), 0.8095 (95% CI, 0.7676‐0.8514), and 0.5730 (95% CI, 0.5173‐0.6287), respectively. Conclusion Platelet count and PLT/WBC may become a potential biomarker of HCA‐related spontaneous preterm birth.

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“…Peripheral blood eosinophilia (PBE) (17) and low albumin has been associated with increased risk of IVIG resistance and coronary complications (14). Low mean platelet volume (MPV) (15), platelet distribution width (PDW) (19), and platelet-derived microparticles (PDMP) (20) have been shown to be markers of platelet activation and inflammation in acute stages of KD. However, their use as biomarkers for the disease requires replication of results across different populations.…”

Section: Inflammatory Biomarkers (Table 1)mentioning

confidence: 99%

Biomarkers for Kawasaki Disease: Clinical Utility and the Challenges Ahead

et al. 2019

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Kawasaki disease (KD) has replaced acute rheumatic fever as the most common cause of acquired heart disease in children in the developed world and is increasingly being recognized from several developing countries. It is a systemic vasculitis with a predilection for coronary arteries. The diagnosis is based on a constellation of clinical findings that appear in a temporal sequence. Quite understandably, this can become a problem in situations wherein the clinical features are not typical. In such situations, it can be very difficult, if not impossible, to arrive at a diagnosis. Several biomarkers have been recognized in children with acute KD but none of these has reasonably high sensitivity and specificity in predicting the course of the illness. A line up of inflammatory, proteomic, gene expression and micro-RNA based biomarkers has been studied in association with KD. The commonly used inflammatory markers e.g. erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and total leucocyte counts (TLC) lack specificity for KD. Proteomic studies are based on the identification of specific proteins in serum, plasma and urine by gel electrophoresis. A host of genetic studies have identified genes associated with KD and some of these genes can predict the course and coronary outcomes in the affected individuals. Most of these tests are in the early stages of their development and some of these can predict the course, propensity to develop coronary artery sequelae, intravenous immunoglobulin (IVIg) resistance and the severity of the illness in a patient. Development of clinical criteria based on these tests will improve our diagnostic acumen and aid in early identification and prevention of cardiovascular complications.

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Platelet-Derived Microparticles: A New Index of Monitoring Platelet Activation and Inflammation in Kawasaki Disease

Abstract: PDMP can be used as an index to monitor inflammation in children at the acute stage of KD. And the duration of platelet activation in KD is individualized.

Cited by 24 publications

References 32 publications

Changes in and significance of platelet function and parameters in Kawasaki disease

Changes in and significance of platelet function and parameters in Kawasaki disease

Maternal peripheral blood platelet‐to‐white blood cell ratio and platelet count as potential diagnostic markers of histological chorioamnionitis‐related spontaneous preterm birth

Biomarkers for Kawasaki Disease: Clinical Utility and the Challenges Ahead

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