Platelet-derived growth factor applications in periodontal and peri-implant bone regeneration

Abstract

Introduction Achieving successful tissue regeneration following traditional therapeutic protocols, combining bone grafts and barrier membranes, may be challenging in certain clinical scenarios. A deeper understanding of periodontal and peri-implant wound healing and recent advances in the field of tissue engineering have enabled clinicians with novel means to obtain predictable clinical outcomes. The use of growth factors such as recombinant human platelet-derived growth factor-BB (rhPDGF) with biocompatible matrices to promote tissue regeneration represents a promising approach in the disciplines of periodontology and implantology. Areas covered This review covers the basic principles of bone and periodontal regeneration, and provides overview of the biology of PDGF and its potential to predictably and reproducibly promote bone regeneration in regular clinical practice. The results of preclinical and clinical human studies evaluating the effectiveness of growth factor-enhanced matrices are analyzed and discussed. Expert opinion Current available evidence supports the use of rhPDGF-enhanced matrices to promote periodontal and peri-implant bone regeneration.

PDGF-metronidazole-encapsulated nanofibrous functional layers on collagen membrane promote alveolar ridge regeneration

“…To further promote healing and regeneration, MTZ was encapsulated in the outer functional layer at a dosage effective to inhibit periodontopathogen, whereas PDGF was encapsulated in the inner functional layer to promote mitogenesis. 11,[14][15][16] The sustained release of MTZ and PDGF ( Figure 1E) inhibited of biofilm formation 23 and enhanced the chemotaxis of MSCs, 24 suggesting that FGM may exert beneficial effects in vivo. …”

“…MTZ is an antibiotic specific to the Gram-negative anaerobic bacteria 11 and is widely used to support dentoalveolar regeneration. 10,12,13 In addition, we incorporated platelet-derived growth factor (PDGF), a potent mitogen and chemoattractant, 14 in the nanofibers on the inner surface to facilitate the healing and regeneration process. We assessed the biocompatibility and applicability of this FGM design in a cell-based system and in rodent models.…”

Effect of PDGF, IGF-1 and PRP on the implant osseointegration. An histological and immunohistochemical study in rabbits

“…Recent studies have suggested that a number of growth factors, including PDGF, promote tissue repair and regeneration, including bone formation; moreover, the efficacy of growth factor therapies in periodontology and implantology has been well characterized in a variety of in vitro and in vivo studies (7,8). The present study, focused on the histological characteristics of the early osseointegration of implants, with or without addition of PRP and PDGF/IGF-1 in combination, in an animal model, demonstrate a higher bone regeneration rate in growth factors-treated group than in PRP or control group.…”

The role of growth factors in extraction wound healing

“…The process of remodeling is slowed down from the 12 th to the 16 th week and the PDGF-level gradually declines 14 . This growth factor has been isolated, and nowadays it is recommended in the treatment of bone defects as highly purified recombinant human rh PDGF-BB 15 .…”