Platelet-Derived Apoptotic Vesicles Promote Bone Regeneration via Golgi Phosphoprotein 2 (GOLPH2)-AKT Signaling Axis
Yuhe Jiang,
Yuan Zhu,
Yuzi Shao
et al.
Abstract:Apoptotic vesicles (apoVs) are apoptotic-cell-derived
nanosized
vesicles that take on dominant roles in regulating bone homeostasis.
We have demonstrated that mesenchymal stem cell (MSC)-derived apoVs
are promising therapeutic agents for bone regeneration. However, clinical
translation of MSC-derived apoVs has been hindered due to cell expansion
and nuclear substance. As another appealing source for apoV therapy,
blood cells could potentially eliminate these limitations. However,
whether blood cells can releas… Show more
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