Platelet‐derived and insulin‐like growth factors stimulate regeneration of periodontal attachment in monkeys

Rutherford, R. Bruce; Niekrash, Christine E.; Kennedy, James E.; Charette, Marc

doi:10.1111/j.1600-0765.1992.tb01679.x

Cited by 186 publications

(137 citation statements)

References 16 publications

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“…Strategies have been developed to guide and control tissue regeneration mechanically by selectively excluding epithelial cells and their extracellular matrix products in the healing process adjacent to the prepared root surfaces (Nyman et al, 1982;Gottlow et al, 1984 (Caffesse et al, 1985;Ripamonti et al, 1987;Wikesjo et al, 1988). Several recent reviews have critically analyzed the histological and clinical results, including those from human studies, following guided tissue regeneration and root conditioning approaches (Terranova and Wikesjo, 1987;Minabe, 1991;Mellonig, 1992;Pitaru et al, 1994 (Lynch et al, 1989(Lynch et al, , 1991Rutherford et al, 1992Rutherford et al, , 1993aGiannobile et al, 1994;Selvig et al, 1994;Park et al, 1995;Cho et al, 1995).…”

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confidence: 99%

Tissue Engineering, Morphogenesis, and Regeneration of the Periodontal Tissues By Bone Morphogenetic Proteins

Ripamonti

Reddi

1997

Critical Reviews in Oral Biology & Medicine

163

129

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Tissue engineering is the emerging field of science developing techniques for fabrication of new tissues for replacement based on principles of cell and developmental biology and biomaterials. Morphogenesis is the cascade of pattern formation and the attainment of form of the various organs and the organism as a whole. The periodontium consists of the periodontal ligament, cementum, and alveolar bone. Bone has considerable potential for regeneration and therefore is a prototypic model for tissue engineering. The three main ingredients for tissue engineering are regulatory signals, responding stem cells, and extracellular matrix. Recent advances in molecular biology of the bone morphogenetic proteins (BMPs) have set the stage for tissue engineering of bone and related tissues, including the periodontium. Bone-derived BMPs, with a collagenous matrix as carrier, induced cementum and alveolar bone regeneration in surgically created furcation defects in the primate. It is noteworthy that there was morphogenesis of periodontal ligament and a faithful insertion of Sharpey's fibers into cementum. In the same furcation model, recombinant human osteogenic protein-l (rhOP-l, also known as BMP-7), in conjunction with the collagenous carrier, induced extensive cementogenesis with insertion of Sharpey's fibers into the newly formed cementum. The observation that BMPs induce cementogenesis and periodontal ligament formation indicates that these proteins may have multiple functions in vivo not limited to cartilage and bone induction. The rapid advances in the molecular biology of BMPs and their receptors bode well for novel strategies to engineer the regeneration of the periodontal tissues.

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mentioning

confidence: 99%

Tissue Engineering, Morphogenesis, and Regeneration of the Periodontal Tissues By Bone Morphogenetic Proteins

Ripamonti

Reddi

1997

Critical Reviews in Oral Biology & Medicine

163

129

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“…The cytokines who generally can be used in the clinical place at present are Platelet Rich Plasma (PRP) 14,15) and EMD in such a situation. PRP is the composite protein that can get it from the self-blood, and tries the intentional replantation of the hopeless tooth with serious bone loss at a serious periodontal disease 16) .…”

Section: Introductionmentioning

confidence: 99%

Regeneration of the Ruffini Endings in the Replanted Rat Incisor with the Application of Emdogain® Gel

Kikuchi

Okada

Siga

et al. 2010

J. Hard Tissue Biology.

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We examined the effect of Emdogain ® Gel (EMD) on the regeneration of periodontal tissue and demonstrated immunohistochemical changes of nerve fiber and mechanoreceptors in the repairing of periodontal ligament (PDL) of a rat replantation model.Maxillary right incisor of male Wistar rats was extracted. After removing pulp tissue from root apex side, the intracanal was filled with warmed gutta-percha by retrograde root canal filling. In the experimental group (EMD group) was used EMD at 0.05ml to root surface before replantation. Untreated group (UT group) was replanted immediately. The samples were extracted on day 3 and at 1, 2 and 4 weeks after surgery. The samples were stained with hematoxylin and eosin (H.E), immunostained with protein gene product 9.5 (PGP 9.5) and Na + , K + -ATPase β1fusion protein (Na + , K + -ATPase). In EMD group was recognized continuing recovery of PDL more quickly than UT group at 1 week. In the EMD group, islet-shaped bones were hypertrophied in the PDL at 1 week. And Na + , K + -ATPase positive reaction which demonstrated recovery of the mechanoreceptors activation was recognized to the Ruffini endings at 1 week. In EMD group was recognized more hypertrophy of alveolar bone at the periradicular than UT group at 2 weeks. In both groups, the constriction of PDL space and the sectional root absorption were recognized at 4 weeks.In conclusion, the continuity of the PDL fiber and the activity of the ruffini endings showed early recovery by applying EMD to the tooth replantation of rat. Bone development was started early even with the PDL and the periradicular alveolar bone. However, the application of EMD couldn't prevent the constriction of PDL space and the root absorption.

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“…Resultados promissores já foram obtidos quando da utilização de fatores de crescimento em situações de reparo tecidua l4, 15,16,17,21,22,23,26,30,33,38 .…”

Section: Introductionunclassified

Plasma rico em plaquetas de coelhos: introdução a um modelo animal experimental

Oliveira-Filho¹,

Almeida²,

Pereira³

et al. 2008

ABCD, arq. bras. cir. dig.

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RACIONAL: Muitas dúvidas ainda permanecem no que se refere às ações dos fatores de crescimento e do plasma rico em plaquetas sobre o mecanismo de reparação tissular. Há necessidade de serem esclarecidos pontos controversos ainda existentes. OBJETIVO: Obter o plasma rico em plaquetas em coelhos através de um método simplificado e ao mesmo tempo adequado, introduzindo um modelo experimental que possa ser utilizado em estudos posteriores. MÉTODOS: Foram utilizados 25 coelhas da raça Nova Zelândia e sem doenças prévias. Quinze mL de sangue de cada animal foi coletado, sendo 10 mL submetidos à dupla centrifugação. Para comprovar a efetividade do método proposto realizou-se contagem mecânica do sangue, bem como do produto final. RESULTADO: Obteve-se uma concentração média de plaquetas no plasma rico em plaquetas 687% maior que a contagem inicial observada no sangue venoso periférico. Para as variáveis: contagem inicial de plaquetas, contagem de plaquetas no plasma rico em plaquetas e enriquecimento, foram obtidos os limites de 95% de confiança para suas médias, sendo que, no que se refere ao percentual de enriquecimento, existe 95% de chance de que o intervalo de (530-844) contenha a média real de enriquecimento de plaquetas. CONCLUSÃO: O método simplificado utilizado permite a obtenção de plasma rico em plaquetas adequado permitindo seu uso em estudos dos fatores de crescimento nos mecanismos de reparação tecidual.

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Platelet‐derived and insulin‐like growth factors stimulate regeneration of periodontal attachment in monkeys

Cited by 186 publications

References 16 publications

Tissue Engineering, Morphogenesis, and Regeneration of the Periodontal Tissues By Bone Morphogenetic Proteins

Tissue Engineering, Morphogenesis, and Regeneration of the Periodontal Tissues By Bone Morphogenetic Proteins

Regeneration of the Ruffini Endings in the Replanted Rat Incisor with the Application of Emdogain® Gel

Plasma rico em plaquetas de coelhos: introdução a um modelo animal experimental

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