Platelet deposition estimation: A novel method for emulating the pump thrombosis potential of blood pumps

Liu, Guang-Mao; Zhang, Yan; Chen, Hai‐bo; Hou, Jianfeng; Jin, Donghai; Gui, Xingmin; Hu, Shengshou

doi:10.1111/aor.13620

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…10 The thrombosis potentials at design points have also been investigated by CFD and in-vitro method. 36 However, the coupled working states have not been completed, this study made up for this vacancy.…”

Section: Discussionmentioning

confidence: 99%

Numerical analysis of different cardiac functions and support modes on blood damage potential in an axial pump

Jin

Gui

et al. 2023

Int J Artif Organs

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Background: Cardiac functions and support modes of left ventricular assist device (LVAD) will influence the pump inner flow field and blood damage potential. Methods: Computational fluid dynamics (CFD) method and lumped-parameter-model (LPM) were applied to investigate the impacts of cardiac functions under full (9000 rpm) and partial (8000 rpm) support modes in an axial pump. Results: The constitution of hemolysis index ([Formula: see text]) in different components of the pump was investigated. [Formula: see text] was found to be more sensitive to positive incidence angles ([Formula: see text]) compared with negative incidence angles in rotors. Negative incidence angles had little impact on [Formula: see text] both in rotors and the outlet guide vanes. The improved cardiac function made only a minor difference in [Formula: see text] (estimated average [Formula: see text] in one cardiac cycle) by 9.88%, as the flow rate expanded mainly to higher flow range. Switching to partial support mode, however, would induce a periodic experience of severe flow separation and recirculation at low flow range. This irregular flow field increased [Formula: see text] by 47.97%, remarkably increasing the blood damage potential. Conclusion: This study revealed the relationship between the blade incidence angle [Formula: see text] and [Formula: see text], and recommended negative-incidence-angle blade designs as it yielded lower [Formula: see text]. Moreover, to avoid flow range below 50% of the design point, careful evaluations should be made before switching support modes as weaning procedures in clinical applications.

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Section: Discussionmentioning

confidence: 99%

Numerical analysis of different cardiac functions and support modes on blood damage potential in an axial pump

Jin

Gui

et al. 2023

Int J Artif Organs

Self Cite

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“…Several positions with high thrombotic possibility were found, such as the guide vanes of stators, the axle journal (the region between the front stator and the impeller), and the impeller blades. [17][18][19][20][21][22] The studies of thrombus in the natural blood vessel and on the implanted materials remind us that before the rapid growing stage, there should be a relatively slow initial forming stage of the thrombus, which could greatly affect the subsequent process of the thrombosis in VADs. [13][14][15][16] Unfortunately, the exact process of the initial formation of the thrombus in VADs and the related hydrodynamic-biological coupling mechanism are still unclear due to complicated interaction between the blood and the VADs, and the difficulty of real-time observation inside these metallic devices.…”

Section: Doi: 101002/admi202300683mentioning

confidence: 99%

“…The VAD consisted primarily of a front stator (including 3 guide vanes and a front bearing), an impeller and a rear stator, as depicted in Figure 1B. The front stator and front bearing of VADs had a high possibility of initial thrombus formation, [17][18][19][20][21][22] so we chose the area around front stator (red frame in Figure 1B) as the observation area. The blood in circulation loop was driven by the VAD and circulated for 10 h. To counteract the anticoagulant effect of sodium citrate added during blood collection and recover the coagulation capacity of the blood, a solution (75 × 10 −3 m CaCl 2 and 35 × 10 −3 m MgCl 2 in physiological saline) was injected at a rate of 0.5 mL min −1 for 10 min via injection port.…”

Section: In Vitro Experiments Of Thrombus Formation In Vadsmentioning

confidence: 99%

The Effect of Flow Field on the Initial Formation of Thrombus in Ventricular Assist Devices

Meng,

Chen,

Zheng

et al. 2023

Adv Materials Inter

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Thrombosis is the main reason for the failure of ventricular assist devices (VADs). It has been acknowledged that the platelet activation induced by the nonphysiological blood flow leads to the increased thrombotic risk. However, due to the complicated influence of the VADs’ flow field and the difficulty in real‐time in situ observation, the mechanisms and process of thrombus formation in VADs remain unclear. In this work, the process of thrombus formation in VADs in vitro experiments is observed. The thrombus is found to form on the middle of the inlet guide vanes first and it is mainly caused by the immediate activation of platelets induced by the high shear rate of the flow field around the vanes and also affected by the rotation of the impeller. Then, subsequent thrombus is found in the tail of guide vanes and around the axle journal, where the blood flow is stagnated and the platelets are activated by the accumulated bioagonists. These findings clarify that the thrombus formed on the inlet guide vanes and the axle journal are dominated by two different mechanisms. This work provides unique insights into the initial formation of the thrombus on VADs and helps to reduce the thrombotic risk.

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“…Due to a shortage of donors, most patients with heart disease cannot be effectively treated right away, but a ventricular assist device (VAD) can usually buy time for patients until a suitable donor is found [3,4]. However, when the blood pump is operating in the human body, if the incidental destruction of red blood cells by the pump exceeds the renewal rate of red blood cells in the body, the ability of oxygen transmission and carbon dioxide removal can be seriously affected, resulting in insufficient oxygen supply to organs and tissues, and even death [5,6]. Currently, the axial blood pump has evolved to a third-generation magnetic design [7,8].…”

Section: Introductionmentioning

confidence: 99%

Effect of Conical Spiral Flow Channel and Impeller Parameters on Flow Field and Hemolysis Performance of an Axial Magnetic Blood Pump

et al. 2022

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For a blood pump, the blood flow channel and impeller parameters directly affect the performance of the pump and the resulting blood circulation. The flow channel in particular has a great impact on the hydraulic performance of the pump (e.g., flow and pressure), which directly determines the overall performance of the blood pump. Traditional bearing-supported blood pumps can cause mechanical damage to blood cells, leading to hemolysis and thrombosis. In this study, therefore, we designed a conical spiral axial blood pump with magnetic levitation. The blood pump was supported by electrodynamic bearings in the radial direction and electromagnetic bearings in the axial direction. The impeller and the front and rear hubs were integrated to minimize blood stagnation and reduce the formation of thrombosis. The hub had a conical spiral flow channel design, which not only reduced the size of the impeller but also increased blood flow and pressure while meeting the design requirements. Computational fluid dynamics (CFD) analysis was used to analyze the flow field of the axial blood pump, a power function model was used to establish a hemolysis prediction model, and the particle tracking method was used to obtain the flow trajectories of individual blood cells, thereby predicting hemolysis-related performance of the blood pump. The simulation results showed that the main high shear stress area in the blood pump was located in the impeller inlet and the clearance between the top of the impeller and the inner chamber of the blood pump. When the hub taper angle of the blood pump was 0.72° and the clearance was 0.3 mm, the average hemolysis prediction value was 0.00216. This prediction value was smaller than that of traditional axial blood pumps. These findings can provide an important reference for the structural design of axial blood pumps and for reducing the hemolysis prediction value.

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Platelet deposition estimation: A novel method for emulating the pump thrombosis potential of blood pumps

Cited by 4 publications

References 29 publications

Numerical analysis of different cardiac functions and support modes on blood damage potential in an axial pump

Numerical analysis of different cardiac functions and support modes on blood damage potential in an axial pump

The Effect of Flow Field on the Initial Formation of Thrombus in Ventricular Assist Devices

Effect of Conical Spiral Flow Channel and Impeller Parameters on Flow Field and Hemolysis Performance of an Axial Magnetic Blood Pump

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