Platelet Defects in Acute Myeloid Leukemia—Potential for Hemorrhagic Events

Bumbea, Horia; Vlădăreanu, Ana Maria; Dumitru, Ion; Popov, Viola Maria; Ciufu, Cristina; Nicolescu, Anca; Onisâi, Minodora; Marinescu, Cristina; Cîşleanu, Diana; Voican, Irina; Sarghi, Sinziana

doi:10.3390/jcm11010118

Cited by 9 publications

(5 citation statements)

References 51 publications

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“…The term platelet activation signaling and aggregation is also consistent with the previous literature that the platelet defects and other hemorrhagic symptoms are widely observed in AML patients [49]. The arachidonic acid metabolism is a process highlighted in a few cancer research publications, but the evidence for their involvement in AML is still accumulating [50,51].…”

Section: Aml Patient With Partial Gain and Partial Deletion Of Chromo...supporting

confidence: 86%

Accurate identification of locally aneuploid cells by incorporating cytogenetic information in single cell data analysis

Gañán-Gómez

et al. 2022

Preprint

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Single-cell RNA sequencing is becoming an increasingly common tool to investigate the cellular population and patients' outcomes in cancer research. However, due to the sparse data and the complex tumor microenvironment, it is challenging to identify neoplastic cells that play important roles in tumor growth and disease progression. This challenge is exaggerated in the research of blood cancer patients, from whom the neoplastic cells can be highly similar to normal cells. Here, we present partCNV/partCNVH, a statistical framework for rapid and accurate detection of aneuploid cells with local copy number deletion or amplification. Our method uses an expectation–maximization (EM) algorithm with mixtures of Poisson distributions while incorporating cytogenetic information to guide the classification (partCNV). When applicable, we further improve the accuracy by integrating a hidden Markov model for feature selection (partCNVH). We evaluate the performance of the proposed methods using extensive simulation studies and three scRNA-seq datasets from patients with blood cancers. In these applications, our proposed methods demonstrate favorable accuracy and more interpretable results compared with existing methods. In the real data analysis, our results identify many biological processes that have or have not been previously validated, implying multiple biological processes involved in the oncogenesis of myelodysplastic syndromes and acute myeloid leukemia.

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Section: Aml Patient With Partial Gain and Partial Deletion Of Chromo...supporting

confidence: 86%

Accurate identification of locally aneuploid cells by incorporating cytogenetic information in single cell data analysis

Gañán-Gómez

et al. 2022

Preprint

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“…Of note, besides low absolute platelet counts in AML patients, defects in activation and aggregation of the existing platelets may contribute to life-threatening hemorrhage. 8 Third, chemotherapy-related pericarditis was possible, albeit unlikely in our case. Previous literature reported hemorrhagic pericardial effusion in patients receiving either high-dose cytarabine (≥1,000 mg/m 2 /day) for more than 2 days or low-dose cytarabine (≤200 mg/m 2 /day) for more than 1 week.…”

Section: Discussionmentioning

confidence: 65%

An Unusual Case of Effusive-Constrictive Pericarditis in the Intensive Care Unit

Tang

Man

et al. 2022

CASE

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“…On a platelet functional level, in a study comparing AML to immune thrombocytopenic purpura (ITP), flow cytometric measurements demonstrated morphologic platelet abnormalities indicative of an intrinsic dysfunction of platelet production and activity [ 63 ]. Moreover, this study and a more recent study comparing AML directly against healthy controls both found a significant reduction in the surface expression of platelet activation markers P-selectin and granulophysin, the platelet adhesion marker GP1b, and the platelet aggregation marker GPIIb-IIIa [ 63 , 64 ]. Such findings suggest potentially significant qualitative as well as quantitative platelet abnormalities contributing to elevated hemorrhage risk in APL and AML.…”

Section: Pathophysiology Of Hemorrhage In Aplmentioning

confidence: 88%

The Coagulopathy of Acute Promyelocytic Leukemia: An Updated Review of Pathophysiology, Risk Stratification, and Clinical Management

Hermsen

Hambley

2023

Cancers

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Acute promyelocytic leukemia (APL) has a well-established mechanism and a long-term prognosis that exceeds that of any other acute leukemia. These improving outcomes are due, in part, to all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), two targeted and highly active agents in this disease. However, there remains a considerable morbidity and mortality risk in APL secondary to clinically significant hemorrhagic and/or thrombotic events. Prevention and treatment of these coagulopathic complications remain significant impediments to further progress in optimizing outcomes for patients with APL. Moreover, the relative rarity of APL hinders adequately powered randomized controlled trials for evaluating APL coagulopathy management strategies. This review draws from peer-reviewed works falling between initial descriptions of APL in 1957 and work published prior to January 2023 and provides an updated overview of the pathophysiology of hemorrhagic and thrombotic complications in APL, outlines risk stratification parameters, and compiles current clinical best practices. An improved understanding of the pathophysiologic mechanisms driving hemorrhage and thrombosis along with the completion of well-designed trials of management strategies will assist clinicians in developing interventions that mitigate these devastating complications in an otherwise largely curable disease.

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Platelet Defects in Acute Myeloid Leukemia—Potential for Hemorrhagic Events

Cited by 9 publications

References 51 publications

Accurate identification of locally aneuploid cells by incorporating cytogenetic information in single cell data analysis

Accurate identification of locally aneuploid cells by incorporating cytogenetic information in single cell data analysis

An Unusual Case of Effusive-Constrictive Pericarditis in the Intensive Care Unit

The Coagulopathy of Acute Promyelocytic Leukemia: An Updated Review of Pathophysiology, Risk Stratification, and Clinical Management

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