Platelet-Covered Nanocarriers for Targeted Delivery of Hirudin to Eliminate Thrombotic Complication in Tumor Therapy

Zhang, Kai; Han, Heyou; Li, Shuting; Zhang, Weiyun; Foda, Mohamed F.; Zhao, Yanli

doi:10.1021/acsnano.2c06666

Cited by 20 publications

(13 citation statements)

References 43 publications

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“…The photothermal efficiency of the metasurface before and after the infiltration with NOA 61 can be estimated based on the time constant value (τ). Such an approach is validated in the Roper model and is widely accepted for assessing the photothermal efficiency of new materials, − as τ is inversely proportional to the photothermal efficiency. The calculated values of τ before and after the infiltration with NOA 61 were 34 and 42 s, respectively (see the Supporting Information for more details).…”

Section: Results and Discussionmentioning

confidence: 99%

Thermoplasmonic Controlled Optical Absorber Based on a Liquid Crystal Metasurface

Petronella,

Madeleine,

De Mei

et al. 2023

ACS Appl. Mater. Interfaces

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Metasurfaces can be realized by organizing subwavelength elements (e.g., plasmonic nanoparticles) on a reflective surface covered with a dielectric layer. Such an array of resonators, acting collectively, can completely absorb the resulting resonant wavelength. Unfortunately, despite the excellent optical properties of metasurfaces, they lack the tunability to perform as adaptive optical components. To boost the utilization of metasurfaces and realize a new generation of dynamically controlled optical components, we report our recent finding based on the powerful combination of an innovative metasurfaceoptical absorber and nematic liquid crystals (NLCs). The metasurface consists of self-assembled silver nanocubes (AgNCs) immobilized on a 50 nm thick gold layer by using a polyelectrolyte multilayer as a dielectric spacer. The resulting optical absorbers show a well-defined reflection band centered in the near-infrared of the electromagnetic spectrum (750−770 nm), a very high absorption efficiency (∼60%) at the resonant wavelength, and an elevated photothermal efficiency estimated from the time constant value (34 s). Such a metasurface-based optical absorber, combined with an NLC layer, planarly aligned via a photoaligned top cover glass substrate, shows homogeneous NLC alignment and an absorption band photothermally tunable over approximately 46 nm. Detailed thermographic studies and spectroscopic investigations highlight the extraordinary capability of the active metasurface to be used as a light-controllable optical absorber.

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Section: Results and Discussionmentioning

confidence: 99%

Thermoplasmonic Controlled Optical Absorber Based on a Liquid Crystal Metasurface

Petronella,

Madeleine,

De Mei

et al. 2023

ACS Appl. Mater. Interfaces

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“…81,82 Integrin GPIIb-IIa on the surface of platelets binds to fibrinogen and aggregates at the site of damaged blood vessels to form a thrombosis. 83,84 In addition, platelets have strong binding ability to blood clots and type IV collagen, which can target damaged blood vessels at tumor sites. 85 Recent studies have shown that Pselectin on platelets specifically binds to the CD44 receptor overexpressed on tumor cells.…”

Section: Biomimetic Nanoparticles Functionalized By Different Kinds O...mentioning

confidence: 99%

Application of cell membrane-functionalized biomimetic nanoparticles in the treatment of glioma

Zhang¹,

Yao²,

Ma³

et al. 2023

J. Mater. Chem. B

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“…In addition, living cell-based nanomaterials can be combined with advanced biofabrication techniques, such as three-dimensional (3D) bioprinting and microfluidics, which have great potential for tissue engineering applications. To this end, various living cells, such as mesenchymal stem cells, [278,279] neural stem cells, [280][281][282][283] dental-pulp stem cells, [284] adipose-derived stem cells, [285] erythrocytes, [136,286,287] leukocytes, [288] NK cells, [289] monocytes, [290,291] macrophages, [62,[292][293][294][295][296][297] neutrophils, [63,[298][299][300] lymphocytes, [301] DCs, [302] and platelets, [303,304] have been exploited to engineer nanomaterials, which is the second type of CCT. Such cellularized nanomaterials have demonstrated great potential as "Trojan horses" for active targeting and therapy of various diseases.…”

Section: Passive Nanoparticles Cloaked With Living Cellsmentioning

confidence: 99%

Biomembrane‐inspired design of medical micro/nanorobots: From cytomembrane stealth cloaks to cellularized Trojan horses

Zhou

Liu

et al. 2023

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Micro/nanorobots are promising for a wide range of biomedical applications (such as targeted tumor, thrombus, and infection therapies in hard‐to‐reach body sites) because of their tiny size and high maneuverability through the actuation of external fields (e.g., magnetic field, light, ultrasound, electric field, and/or heat). However, fully synthetic micro/nanorobots as foreign objects are susceptible to phagocytosis and clearance by diverse phagocytes. To address this issue, researchers have attempted to develop various cytomembrane‐camouflaged micro/nanorobots by two means: (1) direct coating of micro/nanorobots with cytomembranes derived from living cells and (2) the swallowing of micro/nanorobots by living immunocytes via phagocytosis. The camouflaging with cytomembranes or living immunocytes not only protects micro/nanorobots from phagocytosis, but also endows them with new characteristics or functionalities, such as prolonging propulsion in biofluids, targeting diseased areas, or neutralizing bacterial toxins. In this review, we comprehensively summarize the recent advances and developments of cytomembrane‐camouflaged medical micro/nanorobots. We first discuss how cytomembrane coating nanotechnology has been employed to engineer synthetic nanomaterials, and then we review in detail how cytomembrane camouflage tactic can be exploited to functionalize micro/nanorobots. We aim to bridge the gap between cytomembrane‐cloaked micro/nanorobots and nanomaterials and to provide design guidance for developing cytomembrane‐camouflaged micro/nanorobots.

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Platelet-Covered Nanocarriers for Targeted Delivery of Hirudin to Eliminate Thrombotic Complication in Tumor Therapy

Cited by 20 publications

References 43 publications

Thermoplasmonic Controlled Optical Absorber Based on a Liquid Crystal Metasurface

Thermoplasmonic Controlled Optical Absorber Based on a Liquid Crystal Metasurface

Application of cell membrane-functionalized biomimetic nanoparticles in the treatment of glioma

Biomembrane‐inspired design of medical micro/nanorobots: From cytomembrane stealth cloaks to cellularized Trojan horses

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