Platelet counts during pregnancy in Chinese women

Zhang, Lixia; Dong, Ning; Yang, Runhua; Li, Ang; Luo, Xuanmei; Yang, Nan; Lu, Hui; Xu, Hua‐Guo

doi:10.1515/labmed-2019-0142

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…A recent report by Reese et al reported that platelet counts in all pregnant women including non-Hispanic white, non-Hispanic black, and Hispanic decrease from the first trimester until the time of delivery [7]. However, little is known about Asian and the article by Xu et al [8] describes the time course of the platelet count in Chinese women during pregnancy.…”

Section: Medical Conditions: Thrombocytopenia In Pregnancymentioning

confidence: 99%

Up-to date platelet testing

Orth

2020

Journal of Laboratory Medicine

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Section: Medical Conditions: Thrombocytopenia In Pregnancymentioning

confidence: 99%

Up-to date platelet testing

Orth

2020

Journal of Laboratory Medicine

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“…The PLT during pregnancy varies depending on the trimester and gradually decreases from the first trimester until delivery. The physiological causes of thrombocytopenia include an increase in plasma volume (dilution effect), accumulation of platelets in the spleen due to spleen enlargement during pregnancy, and accumulation of platelets in the intervillous space of the placenta [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Magnitude of Thrombocytopenia and Associated Factors among Pregnant Women Attending the Antenatal Care Service Unit of Wachemo University Nigist Ellen Mohammed Comprehensive Specialized Hospital Hosanna, Southern Ethiopia

Tirago,

Yemane,

Tadasa

2024

Advances in Hematology

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Background. Thrombocytopenia is the second most common hematological disorder in pregnancy after anemia worldwide and affects 7-8% of all pregnancies. Pregnant women with thrombocytopenia have complications of excessive bleeding during or after childbirth, exudation at the cesarean section, and neonatal thrombocytopenia. Therefore, the main aim of this study was to assess the magnitude of thrombocytopenia and its associated factors among pregnant women attending the Antenatal Care Service Unit of Wachemo University Nigist Ellen Mohammed Comprehensive Specialized Hospital Hosanna, Southern Ethiopia. Materials and Methods. A cross-sectional study was conducted from June 1 to August 30, 2022, involving 209 consecutive pregnant women who came to the hospital during the study period for antenatal care follow-up. Sociodemographic, reproductive, and other clinical data were collected using a structured questionnaire. A four-milliliter venous blood specimen was collected for complete blood analysis and peripheral blood smear. The data were analyzed by using SPSS version 25. Descriptive statistical analysis and bivariate and multivariate logistic regression analyses were performed. A P value ≤0.05 was considered to indicate statistical significance. Results. The overall magnitude of thrombocytopenia among pregnant women was 14.8% (95% CI: 10, 19.6). The prevalence of mild, moderate, and severe thrombocytopenia was 77.4%, 16.1%, and 6.5%, respectively. Multivariate logistic regression revealed that rural residence (AOR = 2.6 and 95% CI = 1.02, 7.12), cigarette smoking (AOR = 8.4 and 95% CI = 1.86, 38), anemia (AOR = 8.3 and 95% CI = 2.7, 25.6), and alcohol consumption (AOR = 8.2 and 95% CI = 2.17–31) were significantly independent factors associated with the development of thrombocytopenia. Conclusion. The magnitude of thrombocytopenia in this study was 14.8%. Rural residence, cigarette smoking, alcohol consumption, and anemia were significantly associated with thrombocytopenia. Therefore, the platelet count should be routinely determined during antenatal care visits for proper diagnosis and to minimize bleeding during and/or after childbirth.

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Peculiarities of morpho-functional characteristics of platelets in women with early and late preeclampsia

Klycheva,

Panova,

Nazarov

et al. 2024

Regional blood circulation and microcirculation

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Introduction. In preeclampsia (PE), the hemostasis system, including the platelet component, changes significantly. The purpose of the work was to identify the peculiarities of the morpho-functional characteristics of platelets in women with early and late PE. Material and methods. The main group consisted of 26 women with early PE and 46 women with late PE. The control group consisted of women with normal pregnancies without hypertensive disorders, of whom 17 were at a gestational age of 260–336 weeks and 42 were at a gestational age of 340–394 weeks. The ADVIA 2120i hematology analyzer was used to evaluate platelet concentration (PLT), platelet distribution width (PDW), mean platelet volume (MPV), concentration of large platelets (Large PLT), percentage of large platelets from the total number of platelets (%LP), mean platelet component concentration (MPC), mean dry platelet mass (MPM). Results. Women with early PE have increased PDW, MPV, LargePlt, %LP and MPM indices compared to women with normal pregnancies up to 34 weeks. Female patients with late PE had lower PLT and higher PDW, %LP, MPC, MPM compared to women with normal pregnancies after 34 weeks. In late PE, PLT is reduced and PDW, %LP and MPM are increased compared to early PE. Conclusion. The detected changes in platelet indices in women with PE, regardless of the period of its onset, indirectly indicate increased thrombopoiesis and high functional activity of young platelets. However, the mechanisms that increase platelet activation in early and late preeclampsia differ.

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Platelet counts during pregnancy in Chinese women

Cited by 3 publications

References 7 publications

Up-to date platelet testing

Up-to date platelet testing

Magnitude of Thrombocytopenia and Associated Factors among Pregnant Women Attending the Antenatal Care Service Unit of Wachemo University Nigist Ellen Mohammed Comprehensive Specialized Hospital Hosanna, Southern Ethiopia

Peculiarities of morpho-functional characteristics of platelets in women with early and late preeclampsia

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