Platelet Counts and Liver Enzymes after Bariatric Surgery

Johansson, Hans-Erik; Haenni, Arvo; Zethelius, Björn

doi:10.1155/2013/567984

Cited by 19 publications

(14 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Contrary to these findings, the results of our study indicated that patients with moderate and severe nonalcoholic fatty liver on ultrasonography have higher platelet counts than those with mild fatty liver. This finding is consistent with those of some recent researches ( 26 , 35 , 36 ). Cao et al for instance, demonstrated that patients with NASH have higher platelet counts than those with hepatic steatosis ( 26 ).…”

Section: Discussionsupporting

confidence: 94%

Association Between Platelet Count as a Noninvasive Marker and Ultrasonographic Grading in Patients With Nonalcoholic Fatty Liver Disease

2015

View full text Add to dashboard Cite

Background:Nonalcoholic fatty liver disease has become a worldwide challenge. Liver biopsy remains the single most reliable approach to determine the severity of this disease. As patients with nonalcoholic fatty liver disease require close follow-up, performing this invasive method repeatedly seems impractical; therefore, designing a noninvasive system to follow up patients has become a common interest.Objectives:We intended to investigate the association between platelet counts of patients with nonalcoholic fatty liver disease and the severity of their disease based on serum levels of liver enzymes and grade of fatty liver on ultrasonography.Patients and Methods:One thousand, three hundred and five patients with nonalcoholic fatty liver disease were included in this descriptive study. Serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and platelet counts of patients were measured. The grade of fatty liver was determined by abdominal ultrasonography.Results:Of our study population, 54.3% (n = 708) were women. Patients with mild fatty liver on ultrasonography had lower platelet counts than those with moderate and severe fatty liver. However, no cutoff value of platelet count could reliably distinguish different grades of fatty liver. We found no significant association between platelet counts and serum levels of AST, ALT or ALP. However, we showed that male patients with abnormal levels of ALT had higher platelet counts.Conclusions:Platelet count in nonalcoholic fatty liver disease can serve as a clue to the severity of disease, but it cannot be considered as a sole test to follow up patients.

show abstract

Section: Discussionsupporting

confidence: 94%

Association Between Platelet Count as a Noninvasive Marker and Ultrasonographic Grading in Patients With Nonalcoholic Fatty Liver Disease

2015

View full text Add to dashboard Cite

show abstract

“…Obesity is associated with an increased risk of NAFLD12 and surgically-induced weight loss improves serum transaminases and hepatic function31323334. In line with these observations, our data provide evidence that sleeve gastrectomy ameliorates hepatic function, as evidenced by an improved profile of AST and ALT, and hepatosteatosis, through the downregulation of lipogenic factors Pparg, Srebf1, Mogat2 and Dgat1.…”

Section: Discussionsupporting

confidence: 83%

Acylated and desacyl ghrelin are associated with hepatic lipogenesis, β-oxidation and autophagy: role in NAFLD amelioration after sleeve gastrectomy in obese rats

Ezquerro

Méndez‐Giménez

Becerril

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Bariatric surgery improves non-alcoholic fatty liver disease (NAFLD). Our aim was to investigate the potential role of ghrelin isoforms in the resolution of hepatic steatosis after sleeve gastrectomy, a restrictive bariatric surgery procedure, in diet-induced obese rats. Male Wistar rats (n = 161) were subjected to surgical (sham operation and sleeve gastrectomy) or dietary interventions [fed ad libitum a normal (ND) or a high-fat (HFD) diet or pair-fed]. Obese rats developed hepatosteatosis and showed decreased circulating desacyl ghrelin without changes in acylated ghrelin. Sleeve gastrectomy induced a dramatic decrease of desacyl ghrelin, but increased the acylated/desacyl ghrelin ratio. Moreover, sleeve gastrectomy reduced hepatic triglyceride content and lipogenic enzymes Mogat2 and Dgat1, increased mitochondrial DNA amount and induced AMPK-activated mitochondrial FFA β-oxidation and autophagy to a higher extent than caloric restriction. In primary rat hepatocytes, the incubation with both acylated and desacyl ghrelin (10, 100 and 1,000 pmol/L) significantly increased TG content, triggered AMPK-activated mitochondrial FFA β-oxidation and autophagy. Our data suggest that the decrease in the most abundant isoform, desacyl ghrelin, after sleeve gastrectomy contributes to the reduction of lipogenesis, whereas the increased relative acylated ghrelin levels activate factors involved in mitochondrial FFA β-oxidation and autophagy in obese rats, thereby ameliorating NAFLD.

show abstract

“…From a previous, small pilot study, we reported a significant reduction in PCs for both RYGBP and biliopancreatic diversion with duodenal switch (BPD-ds) during the first year after surgery. However, the reduction was sustained only in the BPD-ds group 3 years after surgery [ 18 ]. The different responses on PCs might be explained by different procedure-related effects on general inflammation and liver steatosis.…”

Section: Discussionmentioning

confidence: 99%

“…Dallel et al have shown a significant decrease in PCs in patients treated with RYGBP [ 13 ]. Previously, we reported in a small pilot study decreased PCs after RYGBP and biliopancreatic diversion with duodenal switch [ 18 ]. The aim of this study was to evaluate changes in liver enzymes, (GGT, ALT), CRP, ferritin and PCs in non-smoking, non-diabetic obese patients treated with RYGBP with follow-up 1 year after surgery.…”

Section: Introductionmentioning

confidence: 99%

Platelet Counts and Liver Enzymes After Gastric Bypass Surgery

Johansson

Wåhlén²,

Aldenbäck

et al. 2017

OBES SURG

Self Cite

View full text Add to dashboard Cite

BackgroundObesity is associated with chronic inflammation, liver steatosis and increased liver enzymes such as gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT), markers for non-alcoholic fatty liver disease (NAFLD) and liver fat content. Increased platelet counts (PCs) are a biomarker reflecting inflammation and the degree of fibrosis in NAFLD. We investigated alterations in PCs, GGT, ALT, C-reactive protein (CRP) and ferritin after Roux-en-Y gastric bypass (RYGBP).MethodsOne hundred twenty-four morbidly obese non-diabetic patients were evaluated before (baseline) and 12 months after (follow-up) RYGBP.ResultsBody mass index (BMI) was reduced from 43.5 kg/m2 (baseline) to 31.1 kg/m2 (follow-up), and p < 0.001 and weight declined from 126.2 to 89.0 kg. PCs decreased from 303 × 109 to 260 × 109/l, p < 0.001. GGT was reduced from 0.63 to 0.38 μkat/l, p < 0.001. ALT decreased from 0.69 to 0.59 μkat/l, p = 0.006. CRP was lowered from 7.3 to 5.4 mg/l p < 0.001 and ferritin from 106 to 84 μg/l p < 0.001. The alterations in PCs correlated with the changes in CRP (r = 0.38, p = 0.001), BMI (r = 0.25, p = 0.012), weight (r = 0.24, p = 0.015) and inversely correlated with ferritin (r = 21, p = 0.036).ConclusionsPCs, GGT and ALT (markers for NAFLD), and CRP and ferritin (markers for inflammation) decreased in morbidly obese after RYGBP. The decrease in PCs correlated with alterations in CRP, BMI, weight and ferritin. The lowering of liver enzymes may reflect a lowered liver fat content and decreased general inflammation.

show abstract

Platelet Counts and Liver Enzymes after Bariatric Surgery

Cited by 19 publications

References 27 publications

Association Between Platelet Count as a Noninvasive Marker and Ultrasonographic Grading in Patients With Nonalcoholic Fatty Liver Disease

Association Between Platelet Count as a Noninvasive Marker and Ultrasonographic Grading in Patients With Nonalcoholic Fatty Liver Disease

Acylated and desacyl ghrelin are associated with hepatic lipogenesis, β-oxidation and autophagy: role in NAFLD amelioration after sleeve gastrectomy in obese rats

Platelet Counts and Liver Enzymes After Gastric Bypass Surgery

Contact Info

Product

Resources

About