Platelet count, mean platelet volume and thrombocytopoietic indices in healthy women and men

Butkiewicz, A; Kemona, H; Dymicka-Piekarska, Violetta; Matowicka-Karna, Joanna; Radziwon, Piotr; Lipska, Alina

doi:10.1016/j.thromres.2005.06.021

Cited by 89 publications

(84 citation statements)

References 19 publications

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“…Gender-dependent differences in the distribution of normal platelet counts have been reported in several studies, with higher counts being observed in females than in males, as was observed by Biino et al 5,17 The inter-and intra-individual components of the variance in platelet count are similar in males and females, suggesting that the gender-dependent differences are most likely due to differences in hormone profiles. Megakaryocytes and platelets express steroid hormone receptors.…”

supporting

confidence: 53%

Determinants of platelet count in humans

Daly¹

2010

Haematologica

109

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supporting

confidence: 53%

Determinants of platelet count in humans

Daly¹

2010

Haematologica

109

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“…In Nigeria, higher platelet counts were reported in women than in men in separate studies conducted in Calabar and Zaria (Eessien et al, 1973;Evelyne et al, 1978). The report of Butkiewicz et al, (2006) also observed gender-dependent platelet count, higher in women than men. The same authors observed that thrombopoietin concentration is also gender-dependent and is lower in women than in men.…”

Section: Discussionmentioning

confidence: 70%

Platelet counts and mean platelet volume amongst elderly Nigerians

Toryila¹,

Amadi²,

Adelaiye

2010

Science World Journal

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The study was conducted in Zaria, Nigeria aimed at determining reference values of Platelet Counts, Mean Platelet Volume and the relationship between the Platelet Count and Mean Platelet Volume. These parameters were determined from 400 healthy elderly subjects comprising 210 males and 190 females. with a mean age of 69.4±7.9 years . 400 young adults were used as control comprising 200 males and females respectively with a mean age of 24.1 ±4.2years. Healthy elderly adults had a mean platelet count of 161.8±3.0 X 10 9/L and 214.5±3.1 X 10 9/L in males and females respectively. Sex and age differences in platelet counts were observed in the elderly subjects (P < 0.05). The mean (SEM) for mean platelet volume for healthy elderly males and females was 9.8±0.6 fl and 9.7±0.6 fl respectively. There was an inverse correlation between mean platelet volume and platelet counts (r = -0.286, P < 0.05). Platelet count was lower in healthy elderly subjects compared to the young adults control (P < 0.05). The use of separate reference value of platelet count in the elderly is advocated.

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“…As a result, we confirmed an upregulating effect of H. pylori infection on peripheral platelet counts around 2.0 × 10 9 /l in female patients with non-ulcer dyspepsia. Most of the previous reports showed higher peripheral platelet counts in females than in males, although they did not assess the H. pylori status [4,6,8,10,11,15,16,17,18]. Romeo et al [17] recently reported that the female predominance begins with age 16 years, suggesting the influence of oestrogen.…”

Section: Discussionmentioning

confidence: 99%

“…Many factors have been reported to influence peripheral platelet counts, such as smoking, sex difference, ethnicity and others [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18]. Concerning sex difference, almost all of the previous reports are in favour of female predominance [4,6,8,10,11,15,16,17,18], although no reports simultaneously assessed the influence of both H. pylori and sex difference. To evaluate the role of H. pylori and sex difference in platelet regulation, we evaluated the influence of both factors on peripheral platelet counts in patients without immunohaematologic disorders.…”

Section: Introductionmentioning

confidence: 99%

<i>Helicobacter pylori</i> Upregulates Peripheral Platelet Counts Mainly in Female Patients

Matsukawa

Kitamura

Iwamoto³

et al. 2011

Acta Haematol

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To evaluate the influence of Helicobacter pylori and sex difference on peripheral platelet counts, dyspeptic patients without immunohaematologic disorders were evaluated. H. pylori infection was verified with the rapid urease test and serum anti-H. pylori IgG antibody. Platelet counts were analysed with a reference to H. pylori infection and sex difference. Among H. pylori-eradicated patients, changes in platelet counts were separately evaluated. Totally, 655 patients were enrolled: 340 patients were infected with H. pylori and 178 patients received eradication therapy, with a success rate of 88.2% (157/178). Females with H. pylori infection definitely manifested elevated platelet counts (infected vs. uninfected 244 ± 57 vs. 219 ± 54 × 10⁹/l; p < 0.0001). H. pylori eradication reduced peripheral platelets by 8 weeks, 5–6 months, 1, 2 and ≧3 years after eradication in females from 248 ± 54 to 237 ± 49, 237 ± 54, 229 ± 48, 238 ± 61 and 232 ± 50 × 10⁹/l (p = 0.0003, 0.0182, 0.0041, 0.0398 and 0.0289), respectively. In males, the reduction was verified by 8 weeks, 1 year and ≧3 years from 226 ± 52 to 217 ± 47, 214 ± 44 and 200 ± 49 × 10⁹/l (p = 0.0464, 0.0164 and 0.0016), respectively. In conclusion, H. pylori infection upregulates platelet counts mainly in females, and eradication reduced peripheral platelets in both sexes. Females appeared more susceptible to H. pylori infection than males with regard to upregulation of platelet counts.

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Platelet count, mean platelet volume and thrombocytopoietic indices in healthy women and men

Cited by 89 publications

References 19 publications

Determinants of platelet count in humans

Determinants of platelet count in humans

Platelet counts and mean platelet volume amongst elderly Nigerians

<i>Helicobacter pylori</i> Upregulates Peripheral Platelet Counts Mainly in Female Patients

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