Platelet count, mean platelet volume, platelet distribution width, and plateletcrit do not correlate with optical platelet aggegation responses in healthy volunteers

Beyan, Cenǵiz; Kaptan, Kürşat; İfran, Ahmet

doi:10.1007/s11239-006-9014-7

Cited by 123 publications

(101 citation statements)

References 21 publications

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“…In healthy human subjects, no correlation was identifi ed between PCT, MPV or PDW values and platelet aggregation results 54 ; however, these relationships could be modifi ed in the presence of infl ammation.…”

Section: Discussionmentioning

confidence: 92%

“…Thus, platelets with a higher MPV are expected to be present in autoimmune thrombocytopenia when megakaryocytic stimulation is present. Conversely, platelets with a lower MPV are expected in thrombocytopenic states associated with marrow hypoplasia or aplasia 54 . Interestingly, 83% of the patients studied had normal MPV, and it appears that neither of these two mechanisms associated with thrombocytopenia was signifi cantly activated.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that PDW increases over storage time because of the formation of abnormally small and large platelets 54 , and it is well known that pseudo-thrombocytopenia occurs as a result of exposure to EDTA when used in blood sampling 56 . There is a need for multi-center and prospective studies with large sample sizes to elucidate the utility and clinical importance of these parameters in malaria.…”

Section: Discussionmentioning

confidence: 99%

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Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia

Martinez-Salazar

Tobón-Castaño

2014

Rev. Soc. Bras. Med. Trop.

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Introduction: Thrombocytopenia is a common complication in malaria patients. The relationship between abnormal platelet profi le and clinical status in malaria patients is unclear. In low and unstable endemic regions where vivax malaria predominates, the hematologic profi les of malaria patients and their clinical utility are poorly understood. The aim of this study was to characterize the thrombograms of malaria patients from Colombia, where Plasmodium vivax infection is common, and to explore the relationship between thrombograms and clinical status. Methods: Eight hundred sixty-two malaria patients were enrolled, including 533 (61.8%) patients infected with Plasmodium falciparum, 311 (36.1%) patients infected with Plasmodium vivax and 18 (2.1%) patients with mixed infections. Results: The most frequently observed changes were low platelet count (PC) and high platelet distribution width (PDW), which were observed in 65% of patients; thrombocytopenia with <50,000 platelets/µL was identifi ed in 11% of patients. Patients with complications had lower PC and plateletcrit (PT) and higher PDW values. A higher risk of thrombocytopenia was identifi ed in patients with severe anemia, neurologic complications, pulmonary complications, liver dysfunction, renal impairment and severe hypoglycemia. The presence of thrombocytopenia (<150,000 platelets/µL) was associated with a higher probability of liver dysfunction. Conclusions: Young age, longer duration of illness and higher parasitemia are associated with severe thrombocytopenia. Our study showed that thrombocytopenia is related to malaria complications, especially liver dysfunction. High PDW in patients with severe malaria may explain the mechanisms of thrombocytopenia that is common in this group of patients.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia

Martinez-Salazar

Tobón-Castaño

2014

Rev. Soc. Bras. Med. Trop.

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“…Many previous studies have demonstrated that platelets have large and variable sizes as can be observed in several clinical conditions, such as hemorrhage and myeloproliferative disorders. The increase may also indicate microvascular dysfunction (Beyan et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

The relationship between some biochemical and hematological changes in type 2 diabetes mellitus

Shehri

2017

Biomed. Res. Ther.

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Introduction: The aim of this study was to investigate various biochemical and hematological parameters in patients with type 2 diabetes mellitus (T2DM) and compare those with non-diabetic subjects (control group). Subjects: The study was conducted on 405 subjects (ages ranging from 26-65 years old; sex matched) who were classified into two groups: diabetic (n=205 subjects; males-105, females-100) and non-diabetic subjects (n=200; males-100, females-100). The study was carried out during the period of November 2016 to April 2017 in the Department of Clinical Laboratory Sciences at the College of Applied Medical Science Al-Dawadmi, Shaqra University in Saudi Arabia (with the collaboration of the General Hospital Al-Dawadmi). Methods: The following various parameters were assessed for all subjects: body mass index (BMI), systolic and diastolic blood pressure (SBP-DBP), fasting blood sugar (FBS), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatise (ALP), total cholesterol (T. Ch), triglyceride (TG), low-density lipoprotein (LDL), high density lipoprotein (HDL), hemoglobin (HB), red blood cell count (RBC), hematocrit (Ht), mean corpuscular volume (MCV), mean corpuscle hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH), red cell distribution width (RDW), platelet count (Plt), mean platelet volume (MPV), platelet distribution width (PDW), total white blood cell count (WBC), lymphocyte count (L), neutrophil count (N), eosinophil count (E), monocyte count (M), basophil count (B), neutrophil/lymphocyte ratio (N/L), and platelet/lymphocyte ratio (P/L). Results: The results showed an increase in the mean values of SGPT, alkaline phosphatase, urea, serum creatinine, total cholesterol, triglyceride, and LDL in the T2DM group relative to the control group. Meanwhile, the mean value of HDL was significantly decreased in the T2DM group compared to the control group (p<0.05). The mean values of hemoglobin, RBC, MCV, MCHC and MCH were significantly decreased in the T2DM group compared to the control group. In contrast, the red cell distribution width significantly increased in the T2DM group versus control group (p<0.05). The mean platelet count was not significantly changed in the T2DM group compared to the control group (p> 0.05), but the mean values of PDW and MPV were significantly higher in the T2DM group compared to the control group (p<0.05). The mean white blood cell count and differential white blood cell was significantly higher in the T2DM group compared to control group (p<0.05). Lastly, the mean neutrophil/lymphocyte ratio and platelet/lymphocyte ratio was not significantly different in the T2DM group compared to control group (p>0.05). Conclusion: In diabetes mellitus type 2 patients, certain biochemical and hematological changes are distinct from healthy subjects. It is important to follow up and monitor these parameters carefully in diabetic patients. Peer Review Details Peer review method: Single-Blind (Peer-reviewers: 02) Peer-review policy Plagiarism software screening?: Yes Date of Original Submission: 30 September 2017 Date accepted: 05 November 2017 Peer reviewers approved by: Dr. Lili Hami Editor who approved publication: Dr. Phuc Van Pham

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“…In addition, LTA is only available at specialized laboratories [4]. Beyan et al mentions that although it implicitly shows the hemostatic function of platelets, LTA isn't routinely used; it is also a very expensive test [5].…”

mentioning

confidence: 99%

Mean platelet volume measurement protocol should be standardized for diabetic retinopathy

Tuzcu

Arıca

İlhan

et al. 2013

Graefes Arch Clin Exp Ophthalmol

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Platelet count, mean platelet volume, platelet distribution width, and plateletcrit do not correlate with optical platelet aggegation responses in healthy volunteers

Cited by 123 publications

References 21 publications

Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia

Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia

The relationship between some biochemical and hematological changes in type 2 diabetes mellitus

Mean platelet volume measurement protocol should be standardized for diabetic retinopathy

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