Platelet Count, Mean Platelet Volume, and Red Cell Distribution Width as Markers for Psoriasis Severity

Nageen, Safina; Shah, Rohan; Sharif, Shawana; Jamgochian, Marielle; Waqas, Nadia; Rao, B. Srihari

doi:10.36849/jdd.6127

Cited by 6 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As regards hematological indices, our research identified significant disparities in MPV and RDW levels among the groups under study, aligning with the outcomes of studies by Aboud et al [ 27 ] and Kim et al [ 28 ]. Yet, our findings diverge from those reported by Saleh et al [ 29 ] and Safina et al [ 30 ], who observed no significant differences in MPV levels between their patient and control groups. They explained their different results as psoriasis’s nature is a chronic inflammatory condition that prompts an increased platelet accumulation in the skin, leading to fewer circulating platelets [ 12 , 31 ].…”

Section: Discussioncontrasting

confidence: 99%

Hematological indices in psoriatic enthesopathy: relation to clinical and ultrasound evaluation

Amer,

Al Shambaky,

Ameen

et al. 2024

Clin Rheumatol

View full text Add to dashboard Cite

Background Enthesopathy is considered a crucial aspect of assessment and outcome in psoriatic arthritis (PsA). Musculoskeletal ultrasound (MSUS) is a critical tool for accurately detecting enthesitis. Recent research focuses on identifying simple biomarkers for detecting and monitoring psoriatic enthesopathy. Red cell distribution width (RDW), mean platelet volume (MPV), and neutrophil/lymphocyte ratio (NLR) are components of a complete blood count (CBC) and are reliable bio-inflammatory markers in various rheumatic diseases. Aim of work To measure MPV, RDW, and NLR in psoriatic enthesopathy and determine their relationship to disease activity and MSUS findings. Patients and methods This study focused on 30 people with psoriatic arthritis (PsA) as per CASPAR criteria, along with 20 control subjects. Enthesopathy was evaluated clinically using the Leeds Enthesitis Index (LEI). The modified Disease Activity Index of Psoriatic Arthritis (DAPSA28) was calculated, and RDW, MPV, NLR, CRP, and ESR were measured. Each enthesis in LEI was radiologically assessed using plain radiography and MSUS according to OMERACT definitions. Results There was a significant relationship between clinical tenderness, the presence of enthesophytes on plain radiography, and MSUS findings at entheses sites (p < 0.001 for each). Psoriatic patients had higher levels of RDW and MPV (p < 0.001 and 0.01, respectively) than controls, with no significant differences in NLR (p = 0.189) between the two groups. RDW and MPV levels were positively correlated with the DAPSA28 score. Conclusion Monitoring PsA disease activity can be improved by considering RDW and MPV as reliable indicators and using them to screen for psoriatic enthesopathy with MSUS indices. Key points • Clinically identifying enthesitis in patients with PsA can be challenging. Imaging MSUS indices hold promise for objective analysis, but there is no consensus on which indices to use in clinical trials and daily practice.• Patients with psoriatic enthesopathy have higher RDW and MPV levels, which are positively correlated with DAPSA28 score.• RDW and MPV can be considered in the turn of improved screening of psoriatic enthesopathy with MSUS scores.

show abstract

Section: Discussioncontrasting

confidence: 99%

Hematological indices in psoriatic enthesopathy: relation to clinical and ultrasound evaluation

Amer,

Al Shambaky,

Ameen

et al. 2024

Clin Rheumatol

View full text Add to dashboard Cite

show abstract

“…Although the cause of this disease, which progresses with remission and relapses, is not known exactly, it is stated that genetic, immunological mechanisms, and subclinical systemic inflammation play an important role in etiopathogenesis [ 6 ]. Various inflammatory mediators, including interleukins, chemokines, inflammatory cytokines, and autoantibodies, have been implicated and reported to reflect disease severity [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Relationship of Hematological Parameters and C-reactive Protein (CRP) With Disease Presence, Severity, and Response to Systemic Therapy in Patients With Psoriasis

Şener,

İnan Yuksel,

Gökdeniz

et al. 2023

Cureus

View full text Add to dashboard Cite

Objectives: Systemic inflammation has an important role in psoriasis, which is a chronic disease with an increasing prevalence and is associated with comorbidity. Our aim is to investigate the relationship of hematological parameters and C-reactive protein (CRP) with the presence and severity of the disease in patients with psoriasis. It is also to investigate whether it can be used as a biomarker in monitoring the response to systemic treatment. Materials and methods: This retrospective study was conducted with the participation of 139 psoriasis patients receiving biological therapy (BT) and conventional therapy (CT) and 140 healthy controls. Demographic, clinical, and laboratory data of patients and controls were examined and all parameters were compared with the psoriasis area severity index (PASI) score. In addition, the changes in these parameters before the treatment and in the third month of the treatment were examined in the patient groups who received BT and CT. Results: White blood cell (WBC), neutrophil, monocytes, platelet (PLT), plateletcrit, red blood cell, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) monocyte-lymphocyte ratio (MLR), red cell distribution width (RDW), CRP and erythrocytesedimentation (ESR) levels were higher compared to the healthy control group in psoriasis patients (p<0.05). Baseline PASI values were positively correlated with WBC, neutrophils, monocytes, NLR, MLR, and CRP. WBC, neutrophil, NLR, CRP, and ESR levels decreased in all patients in the third month of treatment (p<0.05). WBC, PLT, neutrophil, and NLR in patients receiving BT; while WBC, neutrophil, NLR, CRP, and ESR levels decreased in patients receiving CT, RDW levels increased (p<0.05). Adalimumab; NLR and basophil, methotrexate; WBC, NLR, neutrophil, and ESR levels caused a significant decrease (p<0.05). Conclusion: The fact that increased WBC, neutrophils, monocytes, NLR, MLR, and CRP levels are associated with the severity of psoriasis indicates that these parameters reflect systemic inflammation in psoriasis. In addition, the decrease in these parameters after BT and CT suggests that they can be considered simple and reliable markers that can be used as a complement to the PASI score in assessing disease severity and response to treatment.

show abstract

“…Regarding MPV, no correlation with PASI scores was identified; however, a previous study indicated that elevated MPV values correlated with disease severity [49]. Regarding RDW, no positive correlation with PASI was identified [21].…”

Section: Hematologic Parameters a Platelet Count B Mean Platelet Volu...mentioning

confidence: 77%

“…The platelet count negatively correlated with disease severity. The authors explain this phenomenon by the fact that numerous platelets are attracted to psoriasis lesions as part of the inflammatory process, leading to a decrease in circulating platelets [21]. Regarding MPV, no correlation with PASI scores was identified; however, a previous study indicated that elevated MPV values correlated with disease severity [49].…”

Section: Hematologic Parameters a Platelet Count B Mean Platelet Volu...mentioning

confidence: 98%

Psoriasis: What Is New in Markers of Disease Severity?

Tampa,

Mitran,

Mitran

et al. 2024

Medicina

View full text Add to dashboard Cite

Introduction. Psoriasis is a chronic inflammatory skin disease and is the result of the interaction between numerous external and internal factors. Psoriasis presents a wide range of skin manifestations encompassing individual lesions varying from pinpoint to large plaques that can evolve into generalised forms. The lesions mirror the pathophysiological mechanisms involved in psoriasis pathogenesis, such as inflammation, dysregulation of immune response, uncontrolled proliferation of keratinocytes and angiogenesis. In this article, we present the latest advances achieved regarding markers that correlate with psoriasis severity. Material and method. We have performed a narrative review on markers of psoriasis severity, including articles published between March 2018–March 2023. Results. We have identified four categories of markers: inflammation markers, oxidative stress markers, hormonal markers and cancer-related markers. The main focus was on inflammation biomarkers, including immunomodulatory molecules, haematological parameters, inflammatory cells and costimulatory molecules. Conclusions. The analysed data indicate that markers associated with inflammation, oxidative stress and hormones, and cancer-related markers could be useful in assessing the severity of psoriasis. Nevertheless, additional research is required to ascertain the practical importance of these biomarkers in clinical settings.

show abstract

Platelet Count, Mean Platelet Volume, and Red Cell Distribution Width as Markers for Psoriasis Severity

Cited by 6 publications

References 0 publications

Hematological indices in psoriatic enthesopathy: relation to clinical and ultrasound evaluation

Hematological indices in psoriatic enthesopathy: relation to clinical and ultrasound evaluation

The Relationship of Hematological Parameters and C-reactive Protein (CRP) With Disease Presence, Severity, and Response to Systemic Therapy in Patients With Psoriasis

Psoriasis: What Is New in Markers of Disease Severity?

Contact Info

Product

Resources

About