Platelet count: Is it a possible marker for severity and outcome of community acquired pneumonia?

ELMaraghy, Ashraf A.; AbdelFattah, Eman Badawy; Ahmed, Mohammed Hassan

doi:10.1016/j.ejcdt.2015.09.001

Cited by 10 publications

(14 citation statements)

References 7 publications

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“…Interestingly, the gene encoding the hypoxia-inducible transcription factors HIF1A locates also near spot J, thus suggesting co-regulation of hypoxia-related pathways. There is also a significant relation between both thrombocytopenia and thrombocytosis and mortality among the patients with CAP, where the platelet count is considered a better positive than a negative predictor value to the outcome ( 70 ). In our data, reduced amounts of mRNA from platelets indeed increases in parallel with the CAP severity score, especially of group 1 (Figure 5 ).…”

Section: Resultsmentioning

confidence: 99%

Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome

et al. 2018

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We analyzed the blood transcriptome of sepsis framed within community-acquired pneumonia (CAP) and characterized its molecular and cellular heterogeneity in terms of functional modules of co-regulated genes with impact for the underlying pathophysiological mechanisms. Our results showed that CAP severity is associated with immune suppression owing to T-cell exhaustion and HLA and chemokine receptor deactivation, endotoxin tolerance, macrophage polarization, and metabolic conversion from oxidative phosphorylation to glycolysis. We also found footprints of host’s response to viruses and bacteria, altered levels of mRNA from erythrocytes and platelets indicating coagulopathy that parallel severity of sepsis and survival. Finally, our data demonstrated chromatin re-modeling associated with extensive transcriptional deregulation of chromatin modifying enzymes, which suggests the extensive changes of DNA methylation with potential impact for marker selection and functional characterization. Based on the molecular footprints identified, we propose a novel stratification of CAP cases into six groups differing in the transcriptomic scores of CAP severity, interferon response, and erythrocyte mRNA expression with impact for prognosis. Our analysis increases the resolution of transcriptomic footprints of CAP and reveals opportunities for selecting sets of transcriptomic markers with impact for translation of omics research in terms of patient stratification schemes and sets of signature genes.

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Section: Resultsmentioning

confidence: 99%

Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome

et al. 2018

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“…This partially matches the results of Georges et al 22 who conducted a multicenter retrospective study showing that severe thrombocytopenia was an independent predictor of mortality for severe community‐acquired pneumonia. But Elmaraghy's study showed that both thrombocytopenia and thrombocytopenia were significantly associated with mortality in patients with community‐acquired pneumonia 23 . Therefore, whether platelets are protective factors for severe COVID‐19 needs to be further verified.…”

Section: Discussionmentioning

confidence: 98%

“…But Elmaraghy's study showed that both thrombocytopenia and thrombocytopenia were significantly associated with mortality in patients with community-acquired pneumonia. 23 Therefore, whether platelets are protective factors for severe COVID-19 needs to be further verified.…”

Section: In Terms Of Laboratory Tests the Main Characteristics Of Comentioning

confidence: 99%

The value of clinical parameters in predicting the severity of COVID‐19

Shi

Dong

Ren

et al. 2020

Journal of Medical Virology

237

168

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To study the relationship between clinical indexes and the severity of coronavirus disease 2019 (COVID‐19), and to explore its role in predicting the severity of COVID‐19. Clinical data of 443 patients with COVID‐19 admitted to our hospital were retrospectively analyzed, which were divided into nonsevere group (n = 304) and severe group (n = 139) according to their condition. Clinical indicators were compared between different groups. The differences in sex, age, the proportion of patients with combined heart disease, leukocyte, neutrophil‐to‐lymphocyte ratio (NLR), neutrophil, lymphocyte, platelet, D‐dimer, C‐reactive protein (CRP), procalcitonin, lactate dehydrogenase, and albumin on admission between the two groups were statistically significant (P < .05). Multivariate logistic regression analysis showed NLR and CRP were independent risk factors for severe COVID‐19. Platelets were independent protective factors for severe COVID‐19. The receiver operating characteristic (ROC) curve analysis demonstrated area under the curve of NLR, platelet, CRP, and combination was 0.737, 0.634, 0.734, and 0.774, respectively. NLR, CRP, and platelets can effectively assess the severity of COVID‐19, among which NLR is the best predictor of severe COVID‐19, and the combination of three clinical indicators can further predict severe COVID‐19.

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“…With respect to alterations in the numbers of circulating platelets in patients hospitalized with severe CAP, both thrombocytopenia (100-106) and thrombocytosis (104)(105)(106)(107)(108), measured in most cases at the time of hospital admission, are associated with significantly increased mortality, either inhospital and/or post-discharge. With respect to alterations in platelet turnover and reactivity, an increase in the mean platelet volume (MPV) measured as an increment over the first 4 days of hospital admission, is, according to one study, a significant predictor of mortality among adult patients admitted to an intensive care unit with severe pneumonia (109).…”

Section: Platelets In the Pathogenesis Of Hyperacute Systemic Inflammmentioning

confidence: 99%

Platelets and Their Role in the Pathogenesis of Cardiovascular Events in Patients With Community-Acquired Pneumonia

Feldman

Anderson

2020

Front. Immunol.

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Community-acquired pneumonia (CAP) remains an important cause of morbidity and mortality throughout the world with much recent and ongoing research focused on the occurrence of cardiovascular events (CVEs) during the infection, which are associated with adverse short-term and long-term survival. Much of the research directed at unraveling the pathogenesis of these events has been undertaken in the settings of experimental and clinical CAP caused by the dangerous, bacterial respiratory pathogen, Streptococcus pneumoniae (pneumococcus), which remains the most common bacterial cause of CAP. Studies of this type have revealed that although platelets play an important role in host defense against infection, there is also increasing recognition that hyperactivation of these cells contributes to a pro-inflammatory, prothrombotic systemic milieu that contributes to the etiology of CVEs. In the case of the pneumococcus, platelet-driven myocardial damage and dysfunction is exacerbated by the direct cardiotoxic actions of pneumolysin, a major pore-forming toxin of this pathogen, which also acts as potent activator of platelets. This review is focused on the role of platelets in host defense against infection, including pneumococcal infection in particular, and reviews the current literature describing the potential mechanisms by which platelet activation contributes to cardiovascular complications in CAP. This is preceded by an evaluation of the burden of pneumococcal infection in CAP, the clinical features and putative pathogenic mechanisms of the CVE, and concludes with an evaluation of the potential utility of the anti-platelet activity of macrolides and various adjunctive therapies.

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Platelet count: Is it a possible marker for severity and outcome of community acquired pneumonia?

Cited by 10 publications

References 7 publications

Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome

Footprints of Sepsis Framed Within Community Acquired Pneumonia in the Blood Transcriptome

The value of clinical parameters in predicting the severity of COVID‐19

Platelets and Their Role in the Pathogenesis of Cardiovascular Events in Patients With Community-Acquired Pneumonia

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