Platelet concentrates produced from whole blood using the Atreus processing system

“…Third, Thomas et al . compared the quality of PCs made from BCs using the Atreus 2C+ system or a manual method. BCs were obtained either with Atreus 2C+ or manually from WB collections following overnight hold of WB at ambient temperature without active cooling.…”

Section: Automation Third Generationmentioning

confidence: 99%

Automation of blood component preparation from whole blood collections

2014

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“…It is well known that WBCs release many potentially harmful proinflammatory and prothrombotic mediators during storage, contributing to what is known as the “storage lesion” (Table I) [7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20; 21; 22; 23]. Removal of leukocytes before storage partially or completely prevents the accumulation of some of these proinflammatory mediators [24; 25].…”

Section: Leukoreductionmentioning

confidence: 99%

Transfusion immunomodulation — the case for leukoreduced and (perhaps) washed transfusions

Lannan

Sahler

Spinelli

et al. 2013

Blood Cells, Molecules, and Diseases

102

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During the last three decades, a growing body of clinical, basic science and animal model data has demonstrated that blood transfusions have important effects on the immune system. These effects include: dysregulation of inflammation and innate immunity leading to susceptibility to microbial infection, down-regulation of cellular (T and NK cell) host defenses against tumors, and enhanced B cell function that leads to alloimmunization to blood group, histocompatibility and other transfused antigens. Furthermore, transfusions alter the balance between hemostasis and thrombosis through inflammation, nitric oxide scavenging, altered rheologic properties of the blood, immune complex formation and, no doubt, several mechanisms not yet elucidated. The net effects are rarely beneficial to patients, unless they are in imminent danger of death due to exsanguination or life threatening anemia. These findings have led to appeals for more conservative transfusion practice, buttressed by randomized trials showing that patients do not benefit from aggressive transfusion practices. At the risk of hyperbole, one might suggest that if the 18th and 19th centuries were characterized by physicians unwittingly harming patients through venesection and bleeding, the 20th century was characterized by physicians unwittingly harming patients through current transfusion practices. In addition to the movement to more parsimonious use of blood transfusions, an effort has been made to reduce the toxic effects of blood transfusions through modifications such as leukoreduction and saline washing. More recently, there is early evidence that reducing the storage period of red cells transfused might be a strategy for minimizing adverse outcomes such as infection, thrombosis, organ failure and mortality in critically ill patients particularly at risk for these hypothesized effects. The present review will focus on two approaches, leukoreduction and saline washing, as means to reduce adverse transfusion outcomes.

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“…Mixing of WB units does not appear to have been investigated previously nor does it appear in most descriptions of component production methods found in the literature, yet desired platelet yields are still reported [5–8]. The aim of this study was to examine the impact of eliminating this nonevidence based step in our component production process, as it is labour intensive, time consuming, and has the additional disadvantage of creating a risk of repetitive strain injury for production staff.…”

Section: Introductionmentioning

confidence: 99%

Process Improvement by Eliminating Mixing of Whole Blood Units after an Overnight Hold Prior to Component Production Using the Buffy Coat Method

Mastronardi

Schubert

Levin

et al. 2013

Journal of Blood Transfusion

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The elimination of a thorough manual mixing of whole blood (WB) which takes place following the overnight hold, but before the first centrifugation step, during buffy coat component production at Canadian Blood Services (CBS) was investigated. WB was pooled after donation and split. Pairs of platelet, red blood cell (RBC), and plasma components were produced, with half using the standard method and half using a method in which the mixing step was eliminated. Quality assessments included yield, pH, CD62P expression and morphology for platelets, hemoglobin, hematocrit, hemolysis, and supernatant K+ for RBCs, and volume and factor VIII activity levels for plasma. All components, produced using either method, met CBS quality control criteria. There were no significant differences in platelet yield between components produced with and without mixing. A significant difference was seen for RBC hemolysis at expiry (P = 0.03), but for both groups, levels met quality control requirements. Noninferiority of components produced without mixing was confirmed for all parameters. Manual mixing is laborious and has a risk of repetitive strain for production staff and its significance is unclear. Elimination of this step will improve process efficiencies without compromising quality.

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Platelet concentrates produced from whole blood using the Atreus processing system

Cited by 12 publications

References 19 publications

Automation of blood component preparation from whole blood collections

Automation of blood component preparation from whole blood collections

Transfusion immunomodulation — the case for leukoreduced and (perhaps) washed transfusions

Process Improvement by Eliminating Mixing of Whole Blood Units after an Overnight Hold Prior to Component Production Using the Buffy Coat Method

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