Platelet Chemokines in New Modes of Action

Chatterjee, Mainak; Gawaz, Meinrad

doi:10.1007/978-3-319-66224-4_10

Cited by 1 publication

(1 citation statement)

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“…The activated platelets release a massive amount of chemokines belonging to both groups: CXCL4 (also known as platelet factor 4 [PF4]), CCL5 (also known as regulated on activation normal T‐cell expressed and secreted [RANTES]), CXCL8 (also known as interleukin‐8 [IL‐8]) and more (Fırat, 2022). These factors participate in mediating chemotaxis, proliferation and differentiation of inflammatory cells (Madhumita Chatterjee, 2019). PF4 induces blood coagulation via the neutralization of heparin‐like molecules (Fırat, 2022).…”

Section: The Role Of Platelets In Inflammationmentioning

confidence: 99%

Potential for modulation of platelet function via adenosine receptors during inflammation

Boncler

Bartczak

Różalski

2023

British J Pharmacology

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Traditionally, platelets are known to play an important role in haemostasis and thrombosis; however, they serve also as important modulators of inflammation and immunity. Platelets secrete adhesion molecules and cytokines, interact with leukocytes and endothelium, and express toll‐like receptors involved in a direct interaction with pathogens. Platelets express A2A and A2B subtypes of receptors for adenosine. The activation of these receptors leads to an increase in cAMP concentration in the cytoplasm, thereby resulting in inhibited secretion of pro‐inflammatory mediators and reduced cell activation. Therefore, platelet adenosine receptors could be a potential target for inhibiting platelet activation and thus down‐regulating inflammation or immunity. The biological effects of adenosine are short‐lasting, because the compound is rapidly metabolized; hence, its lability has triggered efforts to synthesize new, longer‐lasting adenosine analogues. In this article, we have reviewed the literature regarding the pharmacological potential of adenosine and other agonists of A2A and A2B receptors to affect platelet function during inflammation.

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Section: The Role Of Platelets In Inflammationmentioning

confidence: 99%