Platelet calmodulin correlates with platelet turnover

Endoh, N; Oh, Hakumei; Itoh, Kuniaki; Asai, Takayoshi; Yoshida, Sho

doi:10.1111/j.1600-0609.1990.tb00346.x

Cited by 3 publications

(2 citation statements)

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“…[ 10 ] The incidence of aplastic anemia varies from 10% to 52.7% of all pancytopenia patients in different studies from all over the world. [ 11 12 ] It was found that the incidence of bleeding manifestation in patients of aplastic anemia having platelet count less than 20,000/cu mm was statistically significant than the patient with platelet count more than 20,000/cu mm (P- value < 0.001). The bleeding manifestation was significantly higher in leukemia group in patients above 14 years of age with a prevalence of 63.6%.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of myelodysplastic syndrome (MDS) in the present study is 10.7% with a male to female ratio of 3:1, and it correlates well with the studies done by studies by Keisu et al . [ 11 ] Other studies show that the incidence of MDS varies from 0% to 14% of all pancytopenia patients. [ 4 16 17 ] The increased risk of bleeding in patients with MDS is typically attributed to both low platelet counts and abnormalities of platelet morphology and function (i.e., platelet aggregation defects).…”

Section: Discussionmentioning

confidence: 99%

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Hemorrhagic manifestation in different etiologies of pancytopenia

Singh

et al. 2021

Journal of Family Medicine and Primary Care

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Background: Pancytopenia is a triage of anemia, leukopenia, and thrombocytopenia. The etiology causing pancytopenia varies depending upon factors such as age, sex, occupation, and geographical distribution. Unfortunately, the major treatises of hematology have not given emphasis on the hemorrhagic manifestation of different etiologies causing pancytopenia. Objective: This observational study was carried out with the aim to identify hemorrhagic manifestation in patients with pancytopenia in eastern India. Design: This study was conducted over a period of two years at the Department of Medicine of a tertiary care teaching institute in eastern India. All the patients with features of anemia, thrombocytopenia, or leukopenia were screened for pancytopenia and a total of 214 cases were selected. Patients were divided into two groups as patients with age more than 14 years constitute group one and the patients less than 14 years constitute the second group. A detailed physical examination, hematological, and biochemical investigation was done to ascertain the hemorrhagic manifestations in pancytopenia patients. Results: In the groups, the most common cause of hemorrhagic manifestation in patients with pancytopenia was aplastic anemic, leukemia, myelodysplastic syndrome, and myelofibrosis. No bleeding manifestation was seen in patients with megaloblastic anemia, kala-azar, hypersplenism, and other causes of pancytopenia. Conclusions: Patients with pancytopenia caused by aplastic anemia, acute leukemia, and myelodysplastic syndrome have more chances of bleeding manifestation as compared with pancytopenia caused by megaloblastic anemia, kala-azar, or hypersplenism.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hemorrhagic manifestation in different etiologies of pancytopenia

Singh

et al. 2021

Journal of Family Medicine and Primary Care

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Packaging zinc, fibrinogen, and factor XIII in platelet α‐granules

Marx

Korner

Mou

et al. 1993

Journal Cellular Physiology

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Zinc(II) accumulated by platelets has profound effects on platelet activity. This study is focused on the distribution of Zn(II) between human platelet subcellular compartments. After incubation with 86Rb+ and platelet lysis, the organelles were separated by sucrose density gradient centrifugation. Fibrinogen served as a marker for alpha-granules. 86Rb+ and factor XIII served as markers for the cytoplasmic fractions. Zn(II) was found to be distributed between the cytoplasm and the alpha-granules, with variations between different individual units. The total platelet Zn concentration and its relative subcellular distribution were dependent on its extracellular level. Incubation of platelets with 100 microM Zn(II) resulted in a twofold increase of its level in the cytoplasm and by one order of magnitude in the alpha-granules. In addition to the anticipated factor XIII activity in the cytoplasmic pool fraction, we found thrombin-inducible factor XIII activity within the alpha-granules. Immunoblotting confirmed the presence of both the a and b subunits of plasma factor XIII (a2b2 form) in the alpha-granules. As fibrinogen is not synthesized in the platelet, we propose that by virtue of their mutual binding, fibrinogen, Zn(II) and plasma factor XIII-a2b2 are simultaneously taken up into the alpha-granules by endocytosis, presumably through the vehicle of the GPIIb/IIIa fibrinogen receptor. A rationale for co-packaging these components within the alpha-granules is that Zn(II) inhibits factor XIII activity and thereby prevents the premature cross-linking of the concentrated fibrinogen prior to platelet activation and secretion. By contrast, cytoplasmic Zn(II) may increase platelet responsiveness to agonists due to its interaction with cytoplasmic modulators of platelet activity.

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Haemostatic Disorders in Diabetes Mellitus

Mayne¹

1992

Diabetes and Atherosclerosis

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Platelet calmodulin correlates with platelet turnover

Cited by 3 publications

References 15 publications

Hemorrhagic manifestation in different etiologies of pancytopenia

Hemorrhagic manifestation in different etiologies of pancytopenia

Packaging zinc, fibrinogen, and factor XIII in platelet α‐granules

Haemostatic Disorders in Diabetes Mellitus

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