Platelet-armored nanoplatform to harmonize janus-faced IFN-γ against tumor recurrence and metastasis

Li, Qian; Zhou, Yaxin; He, Wenbo; Ren, Xiaomeng; Zhang, Mengzhu; Jiang, Yue; Zhou, Zhaocai; Luan, Yuxia

doi:10.1016/j.jconrel.2021.08.020

Cited by 75 publications

(34 citation statements)

References 40 publications

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“…There are studies demonstrating that MDR could be potentially overcome by circumventing P-gp-mediated drug efflux with nano-drug delivery system (NDDS), such as nanotube, micelle, liposome, and nanometal material. The NDDS utilizes smart and special mechanisms to achieve drug release in designated circumstances (such as pH, hypoxia, and reducibility) or drug accumulation in tumors via passive targeting (EPR effect) or active targeting (ligand-receptor binding) (Li et al., 2021c ; Zhou et al., 2020 ).…”

Section: Circumventing the Drug-resistant Cancer Cell Drug Effluxmentioning

confidence: 99%

Recent advances in anti-multidrug resistance for nano-drug delivery system

Wang

Zhang

et al. 2022

Drug Delivery

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Chemotherapy for tumors occasionally results in drug resistance, which is the major reason for the treatment failure. Higher drug doses could improve the therapeutic effect, but higher toxicity limits the further treatment. For overcoming drug resistance, functional nano-drug delivery system (NDDS) has been explored to sensitize the anticancer drugs and decrease its side effects, which are applied in combating multidrug resistance (MDR) via a variety of mechanisms including bypassing drug efflux, controlling drug release, and disturbing metabolism. This review starts with a brief report on the major MDR causes. Furthermore, we searched the papers from NDDS and introduced the recent advances in sensitizing the chemotherapeutic drugs against MDR tumors. Finally, we concluded that the NDDS was based on several mechanisms, and we looked forward to the future in this field.

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Section: Circumventing the Drug-resistant Cancer Cell Drug Effluxmentioning

confidence: 99%

Recent advances in anti-multidrug resistance for nano-drug delivery system

Wang

Zhang

et al. 2022

Drug Delivery

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“…Nevertheless, the therapeutic effect of surgery on melanoma is limited, and traditional drugs such as doxorubicin and etoposide are highly resistant and often cause a variety of side effects (Soengas & Lowe, 2003 ; Pugazhendhi et al., 2018 ). Immunotherapy has a particular curative effect on melanoma, but its high cost and complexity significantly limit its clinical application (Del Paggio, 2018 ; Zhou et al., 2020 ; Li et al., 2021 ; Zhang et al., 2022 ). Hence, it is necessary to develop a novel anticancer agent with low side effects and significant curative effects for melanoma.…”

Section: Introductionmentioning

confidence: 99%

Preparation of PEG/ZIF-8@HF drug delivery system for melanoma treatment via oral administration

et al. 2022

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Melanoma is one of the highly malignant tumors whose incidence and fatality rates have been increased year by year. However, in addition to early surgical resection, there still lacks specific targeted drugs and treatment strategies. In this study, it was discovered that hinokiflavone (HF) encapsulated in zeolitic imidazolate framework-8 (ZIF-8) exhibited a superior anti-melanoma effect in vitro and in vivo . HF was encapsulated in ZIF-8 through a one-step synthesis method, and polyethylene glycol (PEG-2000) was used to optimize the size and dispersion of the drug-loaded complex (PEG/ZIF-8@HF). The results show that the prepared PEG/ZIF-8@HF has a high encapsulation efficiency (92.12%) and can achieve selective drug release in an acidic microenvironment. The results of in vitro anti-melanoma experiments indicate that PEG/ZIF-8@HF shows up-regulation of reactive oxygen species (ROS) levels and can restrain the migration and invasion of B16F10 cells. Moreover, in vivo animal experiments further confirm that PEG/ZIF-8@HF shows anti-tumor effect by up-regulating the pro-apoptotic proteins caspase-3 and caspase-8, and down-regulating the migration-promoting invasion protein MMP-9. This study developed a safe and effective oral administration of HF based on the high-efficiency delivery ZIF-8 system, which provides an effective treatment strategy for melanoma.

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“…There are several drawbacks of systemic administration of a single chemotherapeutic, and the combination therapy is sequentially developed to overcome multi-drug resistance and side effects because of using a lower concentration of each drug (Zhang et al., 2016 ; Bayat et al, 2017 ; Ramasamy et al 2017 ). Currently, a variety of nanotechnologies have been extensively applied to improve delivery systems for cancer treatment (Zhou et al., 2020 ; Li et al., 2021a ; Li et al., 2021b ; Sohail et al., 2021c ; Zhang et al., 2022 ). Co-loading of multiple anti-cancer drugs into a single nanocarrier system provides a logical approach to combination therapy, and various collections of nanocarriers are included, for example, liposomes, dendrimers, nanoparticles, micelles etc.…”

Section: Introductionmentioning

confidence: 99%

Complex polymeric nanomicelles co-delivering doxorubicin and dimethoxycurcumin for cancer chemotherapy

Sohail

Sun

et al. 2022

Drug Delivery

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Combinational therapy is a new trend in medical sciences to achieve a maximum therapeutic response of the drugs with a comparatively low incidence of severe adverse effects. To overcome the challenges of conventional formulations for cancer chemotherapy, a polymer-based complex nanomicellar system, namely CPM-DD, was developed co-delivering the anti-cancer agent doxorubicin (DOX) and potent antioxidant dimethoxycurcumin (DiMC). The optimal mass ratio of DOX/DiMC in CPM-DD was determined as 1:6 due to the synergistic antiproliferative effect from in vitro cytotoxicity assay, while the biocompatible diblock copolymer of mPEG2000-PLA5000 was selected for drug entrapment at an optimal feeding ratio of 9:1 to both drugs together. The uniform particles of CPM-DD with suitable particle size (∼30 nm) and stable drug loading content (>9%) could be reliably obtained by self-assembly with the encapsulation yield up to 95%. Molecular dynamics simulation revealed the interaction mechanism responsible for forming these complex nanomicelles. The acid-base interaction between two drugs would significantly improve their binding with the copolymer, thus leading to good colloidal stability and controlled drug release characteristics of CPM-DD. Systematic evaluation based on the MCF-7 breast tumor-bearing nude mice model further demonstrated the characteristics of tissue biodistribution of both drugs delivered by CPM-DD, which were closely related to the drug loading pattern and greatly responsible for the improved anti-cancer potency and attenuated toxicity of this complex formulation. Therefore, all the findings indicated that CPM-DD would be a good alternative to the conventional formulations of DOX and worthy of clinical application for cancer chemotherapy.

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Platelet-armored nanoplatform to harmonize janus-faced IFN-γ against tumor recurrence and metastasis

Cited by 75 publications

References 40 publications

Recent advances in anti-multidrug resistance for nano-drug delivery system

Recent advances in anti-multidrug resistance for nano-drug delivery system

Preparation of PEG/ZIF-8@HF drug delivery system for melanoma treatment via oral administration

Complex polymeric nanomicelles co-delivering doxorubicin and dimethoxycurcumin for cancer chemotherapy

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