Platelet and Erythrocyte Membrane Fluidity Changes in Alcohol-Dependent Patients Undergoing Acute Withdrawal

Thompson, Paul

doi:10.1093/alcalc/34.3.349

Cited by 15 publications

(6 citation statements)

References 23 publications

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“…These results are in line with the well known use of platelets as a model for the serotonergic neurons of patients with mood disorders (Coleman, 1971;Takahashi, 1976;Sthal, 1977;Kim et al, 1982;Dreux and Launay, 1985;Arora and Meltzer, 1989;Thompson, 1999;Camacho and Dimsdale, 2000;Plein and Berk, 2001). …”

Section: Introductionsupporting

confidence: 83%

Do mood disorders play a role in pig welfare?

Cocchi

Sardi

Tonello

et al. 2009

Italian Journal of Animal Science

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The work examines the hypothesis that the behavioural disorders found in pigs under conditions of stress may also be attributable to inherent conditions of alteration in mood. In light of new evidence that links the biochemical characterization of human depression to a particular profile of fatty acids in platelets, in particular the Palmitic Acid, Linoleic and Arachidonic, the decision was made to investigate platelet fatty acids of different animal species (pig, cattle, cat, sheep), together with the same data found in literature for rats and guinea pigs. The results obtained from normal and depressed human subjects have made it possible to achieve a particular Artificial Neural Network called the Self Organizing Map (SOM). This network, which is also used in the classification of some species (pigs, cattle, cats and sheep), has been utilised to distribute and classify all the animals studied, in agreement with the fatty acid markers of depressive disorder and the degree of saturation of membrane lipids. In agreement with this approach, the pig is comparable to humans that present a clinical diagnosis of depression. A critical analysis of specific references indicates the existence of a wide range of similarities between human beings suffering from depression and pigs. All the results we obtained on platelets, together with bibliographic evidence make plausible, in our view, the hypothesis that the pig is an animal intrinsically prone to depression. This tendency, which is probably genetically predetermined, must be taken into account in studies on the welfare of this animal and could also serve as a good model for the study of antidepressant molecules for humans.

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Section: Introductionsupporting

confidence: 83%

Do mood disorders play a role in pig welfare?

Cocchi

Sardi

Tonello

et al. 2009

Italian Journal of Animal Science

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“…Furthermore, despite the fact that it is widely shown in vitro that the consumption of ethanol gives rise to membranes resistant to its disordering effect [19,20], there is little information available concerning adaptative mechanisms to ethanol at cell level. For this reason we have examined the possible adaptative metabolic changes to ethanol by incubating hepatocytes from control and ethanol-treated rats in the presence and absence of 100 mM ethanol, analyzing the individual steps of the biosynthesis of neutral lipids and phospholipids.…”

Section: Resultsmentioning

confidence: 99%

Chronic ingestion of ethanol stimulates lipogenic response in rat hepatocytes

2001

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We isolated hepatocytes from rats chronically fed with ethanol and pair-fed control rats and incubated them both in the presence and absence of 100 mM ethanol in order to analyze the uptake into their lipids of several radiolabeled exogenous substrates. The hepatocytes treated chronically with ethanol showed higher lipogenic activity both in neutral lipids and phospholipids from serine, ethanolamine, glycerol and oleate. The only exception found was in the incorporation of choline into phosphatidylcholine (PC), which was lower in the hepatocytes from ethanol-fed rats than in the controls and was concomitant with a decrease in the PC levels of the ethanol-fed hepatocytes. The results obtained after exposing the cells to 100 mM ethanol in vitro indicate that in general the hepatocytes from ethanol-fed rats exhibit a higher lipogenic activity than the control cells. The only difference in the response to ethanol in vitro was found in the biosynthesis of phosphatidylserine (PS) from serine, which rose significantly in control cells but was unaffected in alcoholic hepatocytes. We put this difference in response down to specific adaptation to ethanol feeding.

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“…These studies suggest that the membranous structure of brain provides a favorable condition to EW insults. The membrane targeting effect of EW is also seen in a clinical situation in which the membrane fluidity of erythrocytes was altered in ethanol withdrawn alcoholic patients [ 28 ]. EW-induced oxidative stress appears to be transient under a certain condition.…”

Section: Ew and Oxidative Stressmentioning

confidence: 99%

Alcohol Withdrawal and Brain Injuries: Beyond Classical Mechanisms

Jung

Metzger

2010

Molecules

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Unmanaged sudden withdrawal from the excessive consumption of alcohol (ethanol) adversely alters neuronal integrity in vulnerable brain regions such as the cerebellum, hippocampus, or cortex. In addition to well known hyperexcitatory neurotransmissions, ethanol withdrawal (EW) provokes the intense generation of reactive oxygen species (ROS) and the activation of stress-responding protein kinases, which are the focus of this review article. EW also inflicts mitochondrial membranes/membrane potential, perturbs redox balance, and suppresses mitochondrial enzymes, all of which impair a fundamental function of mitochondria. Moreover, EW acts as an age-provoking stressor. The vulnerable age to EW stress is not necessarily the oldest age and varies depending upon the target molecule of EW. A major female sex steroid, 17β-estradiol (E2), interferes with the EW-induced alteration of oxidative signaling pathways and thereby protects neurons, mitochondria, and behaviors. The current review attempts to provide integrated information at the levels of oxidative signaling mechanisms by which EW provokes brain injuries and E2 protects against it.

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Platelet and Erythrocyte Membrane Fluidity Changes in Alcohol-Dependent Patients Undergoing Acute Withdrawal

Cited by 15 publications

References 23 publications

Do mood disorders play a role in pig welfare?

Do mood disorders play a role in pig welfare?

Chronic ingestion of ethanol stimulates lipogenic response in rat hepatocytes

Alcohol Withdrawal and Brain Injuries: Beyond Classical Mechanisms

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