Platelet alpha2-adrenergic receptor binding to 3H-yohimbine and personality variations in normals

Shekim, Walid O.; Bylund, David B.; Frankel, Fred H.; Alexon, Joyce; Corcoran, Colleen M.; McAllister, Jeannie; Ray-Prenger, C

doi:10.1016/0165-1781(90)90078-j

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…A platelet-rich plasma was prepared immediately after the blood was drawn according to methods described elsewhere [27], The val ues for alphai-adrenergic receptor binding are the specific binding at 0.28 nm /3H/yohimbine. For some subjects, this was determined directly using 0.28 n.V//3H/yohimbine.…”

Section: A Ipha^-a Drenergic Receptor Binding Assaymentioning

confidence: 99%

Platelet Alpha2-Adrenergic Receptor Binding and the Effects of d-Amphetamine in Boys with Attention Deficit Hyperactivity Disorder

et al. 1994

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Presynaptic inhibitory alpha-adrenergic receptors are involved in regulating the release of norepinephrine (NE) through a negative feedback mechanism mediated by NE. Increased alpha₂-adrenergic receptor activity suggests decrease NE release and activity, while decreased alpha₂-adrenergic activity suggests increase NE release and activity. A large body of evidence suggests the involvement of a disturbance in NE activity in the pathophysiology of attention deficit hyperactivity disorder (ADHD) in childhood. Platelet alpha₂-adrenergic receptor binding was compared in 23 boys aged 7–12 with the diagnosis of ADHD and 11 normal controls. The ADHD boys tended to have lower levels of alpha₂-binding than controls. The administration of d-amphetamine in a double-blind placebo-controlled crossover design did not have any effect on alpha₂-receptor binding in ADHD boys. Nonresponders to d-amphetamine had the lowest alpha₂-receptor binding compared to responders and controls. These findings suggest a normal alpha₂-adrenergic activity in ADHD boys responders to d-amphetamine and a possible increase in NE release in ADHD boys nonresponders to d-amphetamine due to decreased alpha₂-adrenergic receptors.

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Section: A Ipha^-a Drenergic Receptor Binding Assaymentioning

confidence: 99%

Platelet Alpha2-Adrenergic Receptor Binding and the Effects of d-Amphetamine in Boys with Attention Deficit Hyperactivity Disorder

et al. 1994

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Psychoactive Herbs in Veterinary Behavior Medicine

Schwartz¹

2005

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Possible involvement of alpha‐2A adrenergic receptors in attention deficit hyperactivity disorder: Radioligand binding and polymorphism studies

Deupree

Smith

Kratochvil³

et al. 2006

American J of Med Genetics Pt B

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Neuropharmacological and genetic association studies have implicated norepinephrine and adrenergic receptors in the pathogenesis of ADHD. The purpose of this study was to compare genetic association studies of three polymorphisms of the alpha-2A adrenergic receptor gene (ADRA2A) with radioligand binding studies of the alpha-2A adrenergic receptor protein in platelets from a sample of children without or with ADHD. The pediatric subjects ranged from 6 to 18 years of age. A thorough clinical assessment of each child resulted in one of the following DSM-IV ADHD diagnoses: inattentive, hyperactive/impulsive, combined, or no ADHD. No significant linkage was found between the ADRA2A polymorphisms (MspI, HhaI, and DraI) and any of the phenotypes tested. Association analysis, however, did detect significant linkage disequilibrium for the DraI polymorphism. Association was also evaluated considering the three ADRA2A single nucleotide polymorphisms as haplotypes. The HhaI-DraI and the MspI-HhaI-DraI haplotypes were significantly associated with ADHD. The platelet alpha-2 adrenergic receptor density did not differ between children without or with ADHD. The affinity of the receptor for the radioligand however, differed significantly between those without and with ADHD. In addition, there were some significant correlations between binding parameters and severity of ADHD in this well-characterized clinical population, and significant association was found between these measures of receptor function and MspI and DraI polymorphisms. Thus, both the genetic and the binding studies indicate that the alpha-2 adrenergic receptor may play a role in ADHD.

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Platelet alpha2-adrenergic receptor binding to 3H-yohimbine and personality variations in normals

Cited by 5 publications

References 17 publications

Platelet Alpha<sub>2</sub>-Adrenergic Receptor Binding and the Effects of <i>d</i>-Amphetamine in Boys with Attention Deficit Hyperactivity Disorder

Platelet Alpha<sub>2</sub>-Adrenergic Receptor Binding and the Effects of <i>d</i>-Amphetamine in Boys with Attention Deficit Hyperactivity Disorder

Psychoactive Herbs in Veterinary Behavior Medicine

Possible involvement of alpha‐2A adrenergic receptors in attention deficit hyperactivity disorder: Radioligand binding and polymorphism studies

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