Abstract:Inhibitory effect of the hot water extracts prepared from various kinds of teas on the platelet aggregation induced by collagen or ADP was investigated by use of turbidimetry. A standard method used was the extraction with 40ml of boiling water for 3min on each 1g tea sample. Examination on various teas with the different manufacturing process indicated that the aggregation inhibitory effect was observed generally on any kind of tea extracts tested, though the activity differed from a strong one (e.g. Japanese… Show more
“…Epigallocatechin gallate (EGCG) as shown in Figure is one of the polyphenols which is found in green teas . EGCG is the most abundant among flavanols such as epicatechin, epicatechin gallate, and epigallocatechin in the tea leaves. , In addition, EGCG is known as a catechin derivative which shows strong biochemical and physiological activities. − 1 Chemical structure of Epigallocatechin gallate.…”
Section: Introductionmentioning
confidence: 99%
“…9 EGCG is the most abundant among flavanols such as epicatechin, epicatechin gallate, and epigallocatechin in the tea leaves. 9,10 In addition, EGCG is known as a catechin derivative which shows strong biochemical and physiological activities. [9][10][11] The polymer-polyphenol interaction has been studied to control the quality of foods and beverages since this interaction induces haze formation and precipitation.…”
Interaction of tamarind seed xyloglucan (TSX) and epigallocatechin gallate (EGCG) was investigated. TSX alone showed the rheological behaviors of dilute and semidilute solution types in the temperature range from 10 to 50 degrees C and the concentration range from 1 to 10%. Addition of a small amount of EGCG changed the rheological properties of TSX solutions to induce a thermoreversible gelation. The sol-gel transition was detected as a crossover of the storage and loss shear moduli at a certain temperature in thermal scanning rheological measurements and an endo- and exo- thermic peaks in curves obtained by differential scanning calorimetry on heating and cooling. High storage modulus of the gels at all experimental frequencies also indicated the formation of a network structure. Increase in the gel strength and the enthalpy of the transition with increasing EGCG concentration at fixed TSX concentration suggested that EGCG was directly involved in the network formation through association with TSX. The TSX gel was obtained by addition of appropriate amount of EGCG. Addition of an excessive amount of EGCG induced precipitation.
“…Epigallocatechin gallate (EGCG) as shown in Figure is one of the polyphenols which is found in green teas . EGCG is the most abundant among flavanols such as epicatechin, epicatechin gallate, and epigallocatechin in the tea leaves. , In addition, EGCG is known as a catechin derivative which shows strong biochemical and physiological activities. − 1 Chemical structure of Epigallocatechin gallate.…”
Section: Introductionmentioning
confidence: 99%
“…9 EGCG is the most abundant among flavanols such as epicatechin, epicatechin gallate, and epigallocatechin in the tea leaves. 9,10 In addition, EGCG is known as a catechin derivative which shows strong biochemical and physiological activities. [9][10][11] The polymer-polyphenol interaction has been studied to control the quality of foods and beverages since this interaction induces haze formation and precipitation.…”
Interaction of tamarind seed xyloglucan (TSX) and epigallocatechin gallate (EGCG) was investigated. TSX alone showed the rheological behaviors of dilute and semidilute solution types in the temperature range from 10 to 50 degrees C and the concentration range from 1 to 10%. Addition of a small amount of EGCG changed the rheological properties of TSX solutions to induce a thermoreversible gelation. The sol-gel transition was detected as a crossover of the storage and loss shear moduli at a certain temperature in thermal scanning rheological measurements and an endo- and exo- thermic peaks in curves obtained by differential scanning calorimetry on heating and cooling. High storage modulus of the gels at all experimental frequencies also indicated the formation of a network structure. Increase in the gel strength and the enthalpy of the transition with increasing EGCG concentration at fixed TSX concentration suggested that EGCG was directly involved in the network formation through association with TSX. The TSX gel was obtained by addition of appropriate amount of EGCG. Addition of an excessive amount of EGCG induced precipitation.
“…Blood samples were collected from healthy adult volunteers, including both men and women ( n = 6, however n = 5 for groups added the concentration after 12 h of taking one clinical dose). Inclusion criteria were non-smokers, not taking aspirin within 2 weeks or other medications (containing NSAIDs) within 1 week before blood collection, and avoiding alcohol, fatty meals, and large amounts of spinach, garlic, Chinese chive, and onion after the evening meal on the day before blood collection because they may affect platelet aggregation activity [ 16 , 17 ]. About 20 mL of blood was collected using a 21G needle into a plastic syringe containing 2 mL of acid-citrate-dextrose (ACD)-A solution.…”
BackgroundLow-dose aspirin irreversibly inhibits platelet cyclooxygenase-1 (COX-1) and suppresses platelet aggregation. It is effective for secondary prevention of cardiovascular events. Because nonsteroidal anti-inflammatory drugs (NSAIDs) reversibly bind with COX-1, the antiplatelet effects of aspirin may be suppressed when NSAIDs are co-administered. This interaction could be avoided by avoiding simultaneous administration; however, the minimum interval that should separate the administration of aspirin and loxoprofen is not well known. In this study, we investigated how to avoid the influence of NSAIDs on the antiplatelet effects of aspirin. An in vitro experiment was performed to investigate the influence of ibuprofen and loxoprofen at various concentrations on aspirin’s antiplatelet action.MethodsPlatelet aggregation and thromboxane B2 (TXB2) levels were measured after addition of aspirin only and NSAIDs plus aspirin to platelet-rich plasma. NSAIDs were used at their maximum plasma concentrations, the assumed concentration after 6 h (for loxoprofen only), and the assumed concentration after 12 h of taking one clinical dose. Platelet aggregation threshold index (PATI), defined as the putative stimulus concentration giving 50% aggregation, was calculated as an index of aggregation activity.ResultsPATI decreased in ibuprofen plus aspirin group compared to that in the aspirin only group, regardless of ibuprofen concentration. Furthermore, PATI significantly decreased when aspirin was added after loxoprofen-trans-OH addition at the maximum concentration (4.1 ± 0.1 μg/mL), compared to that in aspirin only group (5.9 ± 0.1 μg/mL). PATI showed no significant difference after addition of loxoprofen at the assumed concentration after 6 h (aspirin only group, 5.0 ± 0.5 μg/mL; loxoprofen-trans-OH plus aspirin group, 4.9 ± 0.4 μg/mL).In addition, TXB2 concentration tended to decrease with increasing PATI.ConclusionsIt is desirable to avoid ibuprofen co-administration with the usual once-daily low-dose aspirin therapy; however, a 6-h interval between loxoprofen and aspirin could avoid this potential interaction when loxoprofen is taken before aspirin.
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