Platelet Aggregation in Waldenstrom’s Macroglöbulinaemia*

Mc, Rozenberg; Dintenfass, L.

doi:10.1055/s-0038-1654864

Cited by 11 publications

(7 citation statements)

References 5 publications

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“…Pachter et al [2] were the first to find decreased PF3 availability in patients with macroglobulinaemia, which was later confirmed by Penny et al [9]. Platelet adhesion and aggregation abnor malities have also been described [3,5,8],…”

Section: Discussionmentioning

confidence: 93%

Platelet Functions in Dysproteinaemia

Kasturi¹,

Saraya²

1978

Acta Haematol

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Platelet functions were studied in 16 patients with multiple myeloma (MM) and 4 with primary macroglobulinemia (PM). The fall in immunoglobulins on therapy was correlated with the status of platelet function. Effect of incubation of normal platelets with immunoglobulins derived from these patients on kaolin-induced platelet factor 3 (PF3) release was studied to elucidate the mechanism of platelet function defect. Results show increased bleeding time, absence or poor platelet adhesion and aggregation, poor PF3 availability and reduced total PF3 in platelets more consistently in PM but to a lesser extent in MM. Normalisation or partial reduction in globulins on therapy was associated with improvement in platelet functions. Incubation of normal platelets with immunoglobulins enhanced the kaolin-induced PF3 availability. It is suggested that in vivo platelet activation may bring about the PF3 release which subsequently manifests as poor PF3 availability and reduction in its total contents.

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Section: Discussionmentioning

confidence: 93%

Platelet Functions in Dysproteinaemia

Kasturi¹,

Saraya²

1978

Acta Haematol

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“…The association of high concentrations of paraproteins and abnormal bleeding is well recognized. The bleeding time (Perkins er all 1970), platelet adhesion (Perkins et al, rg~o), platelet factor 3 availability (Pachter et al, 1959), clot retraction (Cohen et al, 1970), and platelet aggregation in a cone rotational viscometer (Rosenberg & Dintenfass, 1965) have all been reported to be abnormal in patients with multiple myeloma or Waldenstrom's macroglobulinaemia. Nine of 10 patients in this study demonstrated varying abnormalities of platelet function.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Serum IgG, Platelet Membrane IgG, and Platelet Function in Hypergammaglobulinaemic States

1979

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Platelet membrane IgG levels were measured by the complement lysis inhibition test, and were correlated with serum IgG levels in 29 patients with elevated immunoglobulins due to multiple myeloma, benign monoclonal gammopathy, systemic lupus erythematosis, rheumatoid arthritis, benign hypergammaglobulinaemic purpura and systemic infection. Platelet membrane IgG was increased in proportion to the elevation of serum IgG with a highly significant correlation coefficient (0.561 5 , P I O.OI), irrespective of the underlying disease state. Further

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“…Normal bleeding time with absence of platelet aggregation in cases of macroglobulinaemia has already been shown by R ozenberg and D intenfass [37], Absence of platelet aggregation along with defective release of PF3 and reduced total content in these patients would suggest an acquired compound platelet abnormality, which can be designated as acquired thromboasthenic deficit thrombopathy.…”

Section: Discussionmentioning

confidence: 56%

A Study of Haemostasis in Macroglobulinaemia

1972

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In 3 patients with dysproteinaemia the defects in haemostasis were investigated: Waldenström’s macroglobulinaemia, macroglobulinaemia associated with undifferentiated malignancy in the marrow, diffuse hypergammaglobulinaemia associated with drug sensitive purpura. Platelet factor 3 release, reduction of its total contents and poor platelet adhesion were found in all 3 patients. Platelet aggregation was absent in 2 patients who had macroglobulinaemia with monoclonal spike. It is suggested that the platelet factor 3 assay may be of value in the investigation of these changes in relation to dysproteinaemias.

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Platelet Aggregation in Waldenstrom’s Macroglöbulinaemia*

Cited by 11 publications

References 5 publications

Platelet Functions in Dysproteinaemia

Platelet Functions in Dysproteinaemia

Correlation between Serum IgG, Platelet Membrane IgG, and Platelet Function in Hypergammaglobulinaemic States

A Study of Haemostasis in Macroglobulinaemia

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