Platelet aggregation during menstrual cycle and pregnancy

Yamazaki, Hiroh; Motomiya, Takeshi; Kikutani, Norihisa; Sakakibara, Chieko; Watanabe, Setsuko; Noguchi, Kunio; Numata, Masahiro

doi:10.2491/jjsth1970.10.287

Cited by 10 publications

(15 citation statements)

References 7 publications

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“…Platelet aggregation has been reported to increase in the follicular phase of the menstrual cycle (Yamazaki et al 1979) and also in women taking oestrogen containing oral contraceptives (McGrath et al 1975; Morris et al 1988), suggesting a possible relation between oestrogen levels and platelet aggregation. Since oestrogen levels are known to increase during normal pregnancy, this may explain the increased platelet aggregation found in our study.…”

Section: Discussionmentioning

confidence: 99%

Increased whole blood platelet aggregation in normal pregnancy can be prevented in vitro by aspirin and dazmegrel (UK38485)

Norris

Sheppard

Bonnar

1992

BJOG

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Objective To determine the effect of normal pregnancy and the early puerperium on whole blood platelet aggregation and to assess the role of thromboxane A2 (TXA2) in platelet aggregation in pregnancy. Design A prospective descriptive study. Setting TCD Medical School, St James's Hospital, Dublin. Subjects Twenty healthy primigravidae who remained normotensive during pregnancy and the puerperium. Interventions 20 ml blood samples were obtained serially at 12, 20, 28, 32 and 36 weeks gestation, during established labour and at 1 h, 24 h, 48 h and 6 weeks after delivery. Main outcome measures Whole blood platelet aggregation in response to aggregating agents ADP, PAF (platelet aggregating factor) collagen, adrenaline and arachidonic acid (AA) at each stage of pregnancy and peuerperium was measured using a particle counting technique. The in vitro effect of aspirin and dazmegrel (thromboxane synthetase inhibitor UK38485) on platelet aggregation in pregnancy was also investigated. Results Platelet aggregation in response to collagen, adrenaline, ADP and AA were increased in the last trimester, during labour and at 1 h after delivery but decreased 24–48 h after delivery. Platelet aggregation in response to AA, collagen and adrenalin was reduced by both aspirin and dazmegrel. Conclusions The earliest and most marked increases in platelet aggregation during normal pregnancy were found in response to AA and collagen. These platelet changes were prevented when whole blood was pre‐incubated with either aspirin or dazmegrel. This suggests that enhanced production of TXA2 is reponsible for increased platelet reactivity in normal pregnancy.

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Section: Discussionmentioning

confidence: 99%

Increased whole blood platelet aggregation in normal pregnancy can be prevented in vitro by aspirin and dazmegrel (UK38485)

Norris

Sheppard

Bonnar

1992

BJOG

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“…It may be that more PGJ2 is needed because the platelets are more readily aggregated during this stage but in the absence of a study of rat platelets over the oestrous cycle that must remain a speculation. It is, however, interesting to note here that two studies with human platelets have reported increased tendencies to aggregate in vitro, at ovulation (Zahavi et al 1973) and during the follicular phase (Yamasaki, Motomiya, Kikutani, Sakakibara, Watanabe, Numuta & Noguchi, 1979).…”

Section: Discussionmentioning

confidence: 60%

Effects of the oestrous cycle on the metabolism of arachidonic acid in rat isolated lung.

Bakhle¹,

Zakrzewski²

1982

The Journal of Physiology

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SUMMARY1. The metabolism of exogenous arachidonic acid perfused through the pulmonary circulation was investigated in lungs taken from rats at different stages ofthe oestrous cycle.2. Following perfusion with [14C]arachidonic acid there was more radioactivity associated with cyclo-oxygenase products in general at pro-oestrus than at any other stage of the cycle.3. Production of6-oxo-prostaglandin Fa, and hence ofprostacyclin (PGI2) was also highest at pro-oestrus.4. Production of thromboxane B2 was highest at pro-oestrus although it was never greater than PGI2 production at any stage.5. Radioactivity retained in lung tissue was mostly present in phospholipid and free fatty acid fractions with the distribution at pro-oestrus being different from the other stages.6. Following perfusion with [14C]oleic acid (which is not a substrate for cyclooxygenase), variations in the distribution of label in radioactivity in lung were also observed. However, these were not related to the stages of the oestrous cycle in the same way as those associated with arachidonic acid.7. We conclude that both pathways of arachidonic acid metabolism in lungoxidation via cyclo-oxygenase and incorporation into phospholipid -are affected by the progress of the oestrous cycle.8. Altered arachidonate metabolism appeared to be associated chiefly with prooestrus and may be linked to those hormones involved in this stage of the oestrous cycle.

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“…It is widely accepted that platelet aggregability is one of the most important factors in thrombogenesis. We have found an enhancement of platelet aggregability under a higher blood level of estrogen in physiological conditions such as a follicular phase in normal menstrual cycle and pregnancy (Yamazaki et al 1979). In the present report, platelet aggregation was examined in two groups of women with uterine myoma before and after ovariectomy to observe the effect of ovarian hormones on platelet function.…”

Section: Introductionmentioning

confidence: 82%

Changes in Platelet Aggregability after Ovariectomy

et al. 1979

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SummaryChanges in platelets in 48 patients with uterine myoma before and after hysterectomy with and without ovariectomy were examined. Bilateral ovariectomy in 25 cases (ovariec-tomized group) and unilateral or non-ovariectomy in 23 cases (control group) were performed at the hysterectomy. Platelet count and an appearance rate of secondary aggregation decreased at one day after and increased at one week after the operation, similarly in both the ovariectomized and the control group. The appearance rate of secondary aggregation was reflected in an intensity of aggregation at 5 min after the addition of reagent to PRP. At one month after the operation, the appearance rate of secondary aggregation induced by 3 μM ADP showed a statistically significant decrease in comparison with the preoperation value (P <0.05) and the enhancement of 5-min aggregation was still observed in the control group, while ceased in the ovariectomized group. The difference between the two groups was significant (P < 0.05). There was almost no change in the speed and intensity of primary and secondary aggregation during the observation period. No significant differences in collagen-induced aggregation were noted between the two groups. The results suggest that ovarian hormones, mainly estrogen, facilitate platelet activation which is mediated by the so-called secondary aggregation.

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Platelet aggregation during menstrual cycle and pregnancy

Cited by 10 publications

References 7 publications

Increased whole blood platelet aggregation in normal pregnancy can be prevented in vitro by aspirin and dazmegrel (UK38485)

Increased whole blood platelet aggregation in normal pregnancy can be prevented in vitro by aspirin and dazmegrel (UK38485)

Effects of the oestrous cycle on the metabolism of arachidonic acid in rat isolated lung.

Changes in Platelet Aggregability after Ovariectomy

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