Platelet aggregability in migraine

Couch, J. R.; Hassanein, Ruth S.

doi:10.1212/wnl.27.9.843

Cited by 153 publications

(67 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5 Lower disaggregability assayed by Davis method has also been reported. 4 In vitro platelet sensitivity to substances such as 5-HT and ADP is higher in migraine patients than in controls. 34 During both headache-free periods and attacks, platelet enzyme defects (MAO, phenolsulphontransferase P) 6 "* and anomalous serotonin uptake have been reported.…”

mentioning

confidence: 97%

Study of platelet activation in migraine: control by low doses of aspirin.

D’Andrea¹,

Toldo²,

Cananzi³

et al. 1984

Stroke

View full text Add to dashboard Cite

SUMMARY Although platelet activation is known to occur during migraine attacks, the cause-effect relationship remains to be determined. This problem was approached by studying the possible occurrence of platelet activation in vivo in headache-free periods of subjects affected by common or classic migraine and, subsequently, by verifying the possibility of its pharmacological control through administration of a classic anti-aggregation drug such as aspirin (ASA). The plasma levels of beta-thromboglobulin 03-TG) and platelet factor 4 (PF4), indices of the occurrence of platelet activation in vivo, were therefore first assayed in both groups of migraine sufferers in the absence of therapy and then during the administration of aspirin (50 mg/daily).In the group of IS patients affected by classic migraine, basal plasma levels of /3-TG and PF4 were significantly higher than control subjects. On the other hand, only /3-TG plasma levels were significantly higher in the group of 18 patients affected by common migraine. Patients suffering from classic migraine showed a high incidence of platelet activation (>90%) in comparison with common migraine patients (-33%). This suggests that platelet activation occurs in vivo in migrainous patients also during headachefree periods.Administration of aspirin to the patients affected by common and classic migraine caused a decrease in plasma /3-TG and PF4 concentration. Consequently, pharmacological treatment with aspirin in adequate dose may prove to be helpful in diminishing the vascular side-effects known to occur in migraine sufferers.

show abstract

mentioning

confidence: 97%

Study of platelet activation in migraine: control by low doses of aspirin.

D’Andrea¹,

Toldo²,

Cananzi³

et al. 1984

Stroke

View full text Add to dashboard Cite

show abstract

“…Moreover, in patients with frequent attacks of migraine with aura, the odds for having subclinical posterior territory infarcts were increased almost 16-fold [44], and in young patients with migraineous stroke, a predilection for posterior circulation lesions was shown [40]. The results of studies showing increased platelet aggregability in patients with migraine support the presumed paradoxical embolic etiology of migraine [97, 98.] Furthermore, both antiplatelet agents and anticoagulants were shown to decrease to some extent the frequency of migraine attacks [89, 90, 99, 100].…”

Section: Pfo and Migrainementioning

confidence: 99%

Migraine and Patent Foramen Ovale: A Residual Coincidence or a Pathophysiological Intrigue?

2006

View full text Add to dashboard Cite

Migraine is one of the most common neurological disorders and one of the most frequent primary headaches. It imposes a significant burden on the affected individuals, society and health care system. As the etiology and pathophysiology of migraine are not well understood, treatment is largely symptomatic. Patent foramen ovale is a remnant of a fetal circulation and is highly prevalent in the general population. Its presence was linked to several disorders including migraine. The aim of this review was to search in the available data the answer to the question whether the link between migraine and patent foramen ovale is coincidental or whether they represent a pathophysiological entity.

show abstract

“…Intriguingly, both migraine and MVP sufferers may show platelet dysfunctions [16]. Platelet hyperaggregability predisposing to formation of intravascular platelet aggregates and mural thrombi [17] has been documented during the migraine attack and during the aura [18]. Recently, a higher prevalence of migraine with aura has been found among subjects with patent foramen ovale than in subjects without the alteration (36% vs. 13%) [19].…”

Section: Migraine and Strokementioning

confidence: 99%

Comorbidities of migraine: a user-friendly overview

et al. 2003

View full text Add to dashboard Cite

Comorbidity of migraine is important from a number of different perspectives. Co-occurrence of different diseases may complicate diagnosis as a high degree of symptomatic overlap may occur among conditions associated with migraine. Furthermore, comorbidity has also important implications for treatment. The commonest comorbidities of migraine are represented by psychiatric disorders, epilepsy, tremor, stroke, and cardiovascular abnormalities.

show abstract

Platelet aggregability in migraine

Cited by 153 publications

References 0 publications

Study of platelet activation in migraine: control by low doses of aspirin.

Study of platelet activation in migraine: control by low doses of aspirin.

Migraine and Patent Foramen Ovale: A Residual Coincidence or a Pathophysiological Intrigue?

Comorbidities of migraine: a user-friendly overview

Contact Info

Product

Resources

About