Platelet ageing: A review

Allan, Harriet E; Vadgama, Ami; Armstrong, Paul C; Warner, Timothy D.

doi:10.1016/j.thromres.2022.12.004

Cited by 11 publications

(6 citation statements)

References 83 publications

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“…On the whole, the physiologic significance of moderate physical activity on platelet traits is to maintain moderate platelet numbers and function and to ensure a normal coagulation response. As a general rule, platelets have a lifespan of approximately Frontiers in Physiology frontiersin.org 7-10 days (Allan et al, 2023). Physical activity helps stimulate the bone marrow to produce new platelets, which has a positive impact on the availability of sufficient numbers of new platelets to enter the circulatory system at the end of the platelet's life span.…”

Section: Discussionmentioning

confidence: 99%

Causal relationship between physical activity and platelet traits: a Mendelian randomization study

Jia,

Wang,

2024

Front. Physiol.

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Introduction: The purpose of this study was to discuss the causal relationship between physical activity and platelet traits.Methods: A dataset from a large-scale European physical activity and platelet traits was collected by using Mendelian randomization of the study. For the analysis, the inverse variance weighting method, weighted median and MR-Egger were used to estimate causal effects. The sensitivity analyses were also performed using Cochran’s Q test, funnel plots and Leave-one-out analysis.Results: Light DIY, other exercises, strenuous sports, walking for pleasure were significantly associated with a decrease in platelet crit. But none of the heavy /light DIY was associated with increase in platelet crit. Other exercises and strenuous sports were associated with decrease in platelet count.Conclusion: Some types of physical activity have a causal relationship with platelet crit and platelet count. However, the types of physical activity we studied have not supported a causal relationship with mean platelet volume and platelet distribution width.

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Section: Discussionmentioning

confidence: 99%

Causal relationship between physical activity and platelet traits: a Mendelian randomization study

Jia,

Wang,

2024

Front. Physiol.

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“…When they compared large and small platelets, they found differences in metabolic activity and aggregation. Notably, they conclude that the larger platelets that aggregate more readily are younger platelets, an observation that remains relevant in contemporary platelet research [ 12 ].…”

Section: Historical and Contemporary Perspectives And Technologiesmentioning

confidence: 99%

“…The properties of platelets change as they age over their lifespan of 7 to 10 days in the circulation. Individuals therefore contain a heterogeneous population of platelets with different properties, determined by how long it has been since those platelets were released into the circulation [ 12 ]. Our knowledge of the properties of younger and older platelets has been improved by the development of new approaches to reliably age platelets [ 51 ].…”

Section: Platelet Heterogeneity At the Cellular Level: Within-individ...mentioning

confidence: 99%

Heterogeneity of platelets and their responses

Thomas,

Kelliher,

Krishnan

2024

Research and Practice in Thrombosis and Haemostasis

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“…Immature platelets are a highly reactive subpopulation that possess greater procoagulant and prothrombotic potential than older platelets [9]. These newly formed platelets, also known as reticulated platelets, are released from the bone marrow primarily in response to thrombopoietin (TPO) and contain higher levels of messenger RNA, which can be detected by nucleic acid dyes, enabling them to be distinguished from their older counterparts [10,11].…”

Section: Introductionmentioning

confidence: 99%

Immature platelet dynamics are associated with clinical outcomes after major trauma

Schofield,

Rossetto,

Armstrong

et al. 2023

Preprint

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BackgroundMajor trauma results in dramatic changes in platelet behavior. Newly-formed platelets are more reactive than older platelets, but their contributions to hemostasis and thrombosis after severe injury have not been previously evaluated.ObjectivesTo determine the relationship between immature platelet metrics and circulating drivers of platelet production with clinical outcomes after major injury.MethodsProspective observational cohort study of adult trauma patients. Platelet counts and the immature platelet fraction (IPF) were measured at admission, 24 hours, 72 hours and 7 days post-injury. Plasma proteins involved in thrombopoiesis were quantified at admission. The primary outcome was in-hospital mortality; secondary outcomes were venous thromboembolic events (VTE) and organ failure.ResultsAt two hours post-injury, immature platelet counts (IPC) were significantly lower in non-survivors (n=40) compared to survivors (n=236; 7.3x109/L vs 10.6x109/L, p=0.009). Similarly, impaired platelet function on thromboelastometry was associated with a lower admission IPC (9.1x109/L vs 11.9x109/L, p<0.001). However, at later timepoints we observed a significantly higher IPF and IPC in patients who developed VTE (21.0x109/L vs 11.1x109/L, p=0.02) and prolonged organ dysfunction (20.9 x109/L vs 11x109/L, p=0.003) compared to those who did not develop complications. Plasma levels of thrombopoietin at admission were significantly lower in in non-survivors (p<0.001), in patients with organ failure (p<0.001) and in those who developed VTE (p=0.04).ConclusionsImmature platelet depletion in the acute phase after major injury is associated with increased morality, whereas excessive immature platelet release at later timepoints may predispose to thrombosis and organ dysfunction.ESSENTIALS-Newly-formed platelets are highly active, but their role in outcomes after major trauma is unknown-Immature platelets were quantified in a cohort of 276 severely injured patients-Early depletion of immature platelets is associated with increased mortality and coagulopathy-Raised immature platelet at later timepoints increases the risk of thrombosis and organ failure

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Platelet ageing: A review

Cited by 11 publications

References 83 publications

Causal relationship between physical activity and platelet traits: a Mendelian randomization study

Causal relationship between physical activity and platelet traits: a Mendelian randomization study

Heterogeneity of platelets and their responses

Immature platelet dynamics are associated with clinical outcomes after major trauma

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