Platelet adhesion on silicon modified hydrogenated amorphous carbon films

Okpalugo, T.I.T.; Ogwu, A. A.; Maguire, Paul; McLaughlin, James

doi:10.1016/s0142-9612(03)00494-0

Cited by 141 publications

(96 citation statements)

References 21 publications

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“…The hemocompatibility and platelet adhesion is a crucial parameter for the preparation of polymers designed for biomedical applications such as catheters, implants, blood bags, etc. When blood comes into contact with a surface, first the adsorption of plasma proteins occurs, followed by platelet adhesion, coagulation and finally thrombus formation [54,55]. Accordingly, a material possessing antibacterial properties capable of switching upon mild transformation to antifouling and hemocompatible properties is of extreme interest to abovementioned biomedical applications.…”

Section: (Meth)acrylic Type Polymersmentioning

confidence: 99%

“…[101] poly (56) The reversible switch was reported on the surface of poly (45) with a structure based on 2-morpholinone [98,102] prepared by SI ATRP. The structure contained a quaternary amine lactone Poly (53) H + (polymer brushes, hydrogel) [100] Poly (54) 14 opened under neutral or basic conditions. An increasing number of bonds in the lactone made the ring formation difficult, hence stronger conditions were necessary to form the ring.…”

Section: Reversible Switch From Polycationic To Polyzwitterionic Statementioning

confidence: 99%

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Switchable Materials Containing Polyzwitterion Moieties

2015

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Abstract:In recent decades, the design and construction of smart materials capable of switching into a polyzwitterionic state by an external trigger have been intensively pursued. Polyzwitterionic states have unique antifouling and surface properties and external triggers, such as pH, light, ions, electric field and CO 2 , cause significant changes in materials with regard to overall charge, ionic strength and wettability. This survey highlights current progress in the irreversible as well as the reversible switching process involving polyzwitterionic moieties, which can, in turn, be applied to studying the interaction of various interfaces with biological species as protein, DNA, bacteria or platelets and also for advanced use.

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Section: (Meth)acrylic Type Polymersmentioning

confidence: 99%

Section: Reversible Switch From Polycationic To Polyzwitterionic Statementioning

confidence: 99%

Switchable Materials Containing Polyzwitterion Moieties

2015

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“…There are many factors which affect the interaction between membrane surface and protein, such as surface charged www.intechopen.com character, surface free energy and topological structure, solution environment (e.g. pH, ionic strength), and protein characters (Leng et al, 2003;Okpalugo et al, 2004). The hydrophilic/hydrophobic character of membrane material plays a relatively important role in the interaction between protein and membrane.…”

Section: Protein Adsorptionmentioning

confidence: 99%

Polyethersulfone Hollow Fiber Membranes for Hemodialysis

Su¹,

Sun²,

Zhao³

2011

Progress in Hemodialysis - From Emergent Biotechnology to Clinical Practice

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“…Doping DLC films with fluorine is favorable and results in antithrombotic effects and the suppression of platelet activation [24]. N or Si doping improves the endothelium cell growth and provides antithrombotic effects [25][26][27][28][29]. The goal of this work is a comparative study of different a-C:H materials (pure and N, Si, and Ti doped a-C:H), deposited as very thin films on polymers by high vacuum coating techniques (direct deposition from ion sources and magnetron sputtering) to correlate effects of the film material, structure and toughness on the gas permeation barrier properties as well as chemical composition and surface topography on the biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Gas Permeation, Mechanical Behavior and Cytocompatibility of Ultrathin Pure and Doped Diamond-Like Carbon and Silicon Oxide Films

et al. 2013

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Protective ultra-thin barrier films gather increasing economic interest for controlling permeation and diffusion from the biological surrounding in implanted sensor and electronic devices in future medicine. Thus, the aim of this work was a benchmarking OPEN ACCESSCoatings 2013, 3 269 of the mechanical oxygen permeation barrier, cytocompatibility, and microbiological properties of inorganic ~25 nm thin films, deposited by vacuum deposition techniques on 50 µm thin polyetheretherketone (PEEK) foils. Plasma-activated chemical vapor deposition (direct deposition from an ion source) was applied to deposit pure and nitrogen doped diamond-like carbon films, while physical vapor deposition (magnetron sputtering in pulsed DC mode) was used for the formation of silicon as well as titanium doped diamond-like carbon films. Silicon oxide films were deposited by radio frequency magnetron sputtering. The results indicate a strong influence of nanoporosity on the oxygen transmission rate for all coating types, while the low content of microporosity (particulates, etc.) is shown to be of lesser importance. Due to the low thickness of the foil substrates, being easily bent, the toughness as a measure of tendency to film fracture together with the elasticity index of the thin films influence the oxygen barrier. All investigated coatings are non-pyrogenic, cause no cytotoxic effects and do not influence bacterial growth.

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Platelet adhesion on silicon modified hydrogenated amorphous carbon films

Cited by 141 publications

References 21 publications

Switchable Materials Containing Polyzwitterion Moieties

Switchable Materials Containing Polyzwitterion Moieties

Polyethersulfone Hollow Fiber Membranes for Hemodialysis

Gas Permeation, Mechanical Behavior and Cytocompatibility of Ultrathin Pure and Doped Diamond-Like Carbon and Silicon Oxide Films

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