Platelet activation of mechanical versus bioprosthetic heart valves during systole

Hedayat, Mohammadali; Asgharzadeh, Hafez; Borazjani, Iman

doi:10.1016/j.jbiomech.2017.03.002

Cited by 62 publications

(60 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…BHVs have many advantages compared to mechanical heart valves; they need less anticoagulant and can be folded for transcatheter valve implantation. These advantages make them ideal for clinical applications …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hybrid Pericardium with VEGF‐Loaded Hyaluronic Acid Hydrogel Coating to Improve the Biological Properties of Bioprosthetic Heart Valves

Lei

Deng

Tang

et al. 2019

Macromolecular Bioscience

View full text Add to dashboard Cite

Bioprosthetic heart valves (BHVs) used in the clinic are mostly fixed by glutaraldehyde and the lack of endothelialization is a major problem for glutaraldehyde‐fixed pericardia. Hyaluronic acid is a major glycosaminoglycan that exists in native heart valves. Coupled with its inherent biocompatibility, it may enhance endothelial adhesion and proliferation when associated with vascular endothelial growth factor (VEGF). In this study, an optimized system is developed to improve the endothelialization of glutaraldehyde‐fixed pericardium. A hybrid pericardium with VEGF‐loaded hyaluronic acid hydrogel coating is developed by the crosslinking of 1,4‐butanediol diglycidyl ether. The adhesion and growth potential of human umbilical vein endothelial cells (HUVECs) on pericardia, platelet adhesion, and calcification by an in vivo rat subdermal implantation model are investigated. The results show improved HUVEC adhesion and proliferation, less platelet adhesion, and less calcification for hybrid pericardium by introducing the coating of VEGF‐loaded hyaluronic acid hydrogel. Thus, the coating of VEGF‐loaded hyaluronic acid hydrogel on pericardium is a promising approach to obtain bioprosthetic valves for clinical applications with increased endothelialization and antithrombotic and anticalcification properties.

show abstract

Section: Introductionmentioning

confidence: 99%

“…These advantages make them ideal for clinical applications. [3] Current clinical BHVs, however, do not have the same bioactive properties as native heart valves. When pericardia are used for BHVs in the clinic, they are likely to cause serious pathological calcification and result in clinical failure.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Pericardium with VEGF‐Loaded Hyaluronic Acid Hydrogel Coating to Improve the Biological Properties of Bioprosthetic Heart Valves

Lei

Deng

Tang

et al. 2019

Macromolecular Bioscience

View full text Add to dashboard Cite

show abstract

“…A similar effect in MHVs was shown by Alemu and Bluestein (). Post‐procedure platelet activation in a MHV and a bioprosthetic heart valve (BHV) was compared by Hedayat et al () using three different models; the linear activation model (Bluestein et al, ), the damage accumulation model (Alemu and Bluestein, ), and Soares model (Sheriff et al, ). It was shown that the activation in the MHV was several times higher than in the BHV for all tested cases.…”

Section: Modeling Thrombus Formationmentioning

confidence: 99%

Modeling thrombus formation and growth

Hosseinzadegan

Tafti

2017

Biotech & Bioengineering

View full text Add to dashboard Cite

The paper reviews the state-of-the-art in computational modeling of thrombus formation and growth and related phenomena including platelet margination, activation, adhesion, and embolization. Presently, there is a high degree of empiricism in the modeling of thrombus formation. Based on the experimentally observed physics, the review gives useful strategies for predicting thrombus formation and growth. These include determining blood components involved in atherosclerosis, effective blood viscosity, tissue properties, and methods proposed for boundary conditions. In addition to the guidelines, ongoing research on the effect of shear stress on platelet margination, activation and adhesion, and platelet-surface interactions are reviewed. Biotechnol. Bioeng. 2017;114: 2154-2172. © 2017 Wiley Periodicals, Inc.

show abstract

“…Predicting the exact values of impact loads exerted from fluids on structures is of great importance due to its many applications, for example, in cardiovascular systems [1][2][3][4][5][6][7] and industrial flows [8,9]. In particular, simulation of fluid-solid interaction (FSI) between a membrane and two fluids have many applications in petrochemical [10] and aerospace industries.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Hydrodynamically Dominated Membrane Rupture, Using Smoothed Particle Hydrodynamics–Finite Element Method

Asadi

Taeibi-Rahni

Akbarzadeh

et al. 2019

Fluids

View full text Add to dashboard Cite

The rupturing process of a membrane, located between two fluids at the center of a three-dimensional channel, is numerically investigated. The smoothed particle hydrodynamics (SPH) and the finite element method (FEM) are used, respectively, for modeling the fluid and solid phases. A range of pressure differences and membrane thicknesses are studied and two different rupturing processes are identified. These processes differ in the time scale of the rupture, the location of the rupture initiation, the level of destruction and the driving mechanism.

show abstract

Platelet activation of mechanical versus bioprosthetic heart valves during systole

Cited by 62 publications

References 36 publications

Hybrid Pericardium with VEGF‐Loaded Hyaluronic Acid Hydrogel Coating to Improve the Biological Properties of Bioprosthetic Heart Valves

Hybrid Pericardium with VEGF‐Loaded Hyaluronic Acid Hydrogel Coating to Improve the Biological Properties of Bioprosthetic Heart Valves

Modeling thrombus formation and growth

Investigation of Hydrodynamically Dominated Membrane Rupture, Using Smoothed Particle Hydrodynamics–Finite Element Method

Contact Info

Product

Resources

About