Platelet Activation and Aggregation Induced by Streptococcus bovis
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            Streptococcus equinus Complex

Pernow, Gustav; Shannon, Oonagh; Öberg, Jonas; Nilson, Bo; Rasmussen, Magnus

doi:10.1128/spectrum.01861-22

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Pathogen Interactions With Platelet Immune Receptors1

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2023

2024

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Cited by 2 publications

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“…In the case of H. pylori , which is not a commensal, platelet activation only occurs with platelets from H. pylori -positive individuals ( 56 ). Streptococcus bovis/Spreptococcus equinus complex also induce platelet aggregation in a FcγRIIa-dependent manner ( 93 ). Peptidoglycan from Bacillus anthracis can also induce platleet activation in an FcγRIIa- and IgG-dependent manner ( 94 ).…”

Section: Pathogen Interactions With Platelet Immune Receptorsmentioning

confidence: 99%

Sepsis – it is all about the platelets

Cox

2023

Front. Immunol.

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Sepsis is accompanied by thrombocytopenia and the severity of the thrombocytopenia is associated with mortality. This thrombocytopenia is characteristic of disseminated intravascular coagulation (DIC), the sepsis-associated coagulopathy. Many of the pathogens, both bacterial and viral, that cause sepsis also directly activate platelets, which suggests that pathogen-induced platelet activation leads to systemic thrombosis and drives the multi-organ failure of DIC. In this paper we review the mechanisms of platelet activation by pathogens and the evidence for a role for anti-platelet agents in the management of sepsis.

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Section: Pathogen Interactions With Platelet Immune Receptorsmentioning

confidence: 99%