Platelet activating factors in depression and coronary artery disease: A potential biomarker related to inflammatory mechanisms and neurodegeneration

Mazereeuw, Graham; Herrmann, Nathan; Bennett, Steffany A. L.; Swardfager, Walter; Xu, Hongbin; Valenzuela, Nico; Fai, Stephen; Lanctôt, Krista L.

doi:10.1016/j.neubiorev.2013.06.010

Cited by 40 publications

(35 citation statements)

References 143 publications

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“…Platelet‐activating factor is a powerful short‐lived chemical mediator of leukocyte functions, platelet aggregation, and neutrophil activation (Mazereeuw et al., 2013). During ischemia, PAF increases and then becomes a proinflammatory messenger via modulating leukocyte‐endothelium adhesion.…”

Section: Discussionmentioning

confidence: 99%

Proinflammatory cytokines correlate with early exercise attenuating anxiety‐like behavior after cerebral ischemia

Zhang

Yan

et al. 2017

Brain and Behavior

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Background and ObjectiveStroke may cause neuropsychiatric problems, which have negative effects on cognitive functions and behavior. Exercise plays an important role in reducing the occurrence and development of stroke, the concrete mechanism is not fully clarified. In this study, we attempted to determine whether early treadmill exercise attenuates anxiety‐like behavior by regulation of inflammation after brain ischemia.MethodWe subjected adult male rats to middle cerebral artery occlusion (MCAO) for 90 min and trained rats started to run on a treadmill from postoperative day 1 to day 14. The effects of treadmill on cognitive functions, anxiety‐like behavior, and immune activation were analyzed by Morris water maze test, open field test, elevated plus maze test, and enzyme‐linked immunosorbent assay.ResultsEarly treadmill exercise significantly improved cognitive function, alleviated anxiety‐like behavior in ischemic rats model; this improvement was associated with significantly decreased activation of astrocytes and microglia cells and proinflammatory markers (platelet‐activating factor [PAF], interleukin‐6 [IL‐6], tumor necrosis factor‐alpha [TNF‐α], intercellular adhesion molecule‐1 [ICAM‐1], and vascular cell adhesion molecule‐1 [VCAM‐1]).ConclusionOur results indicated that early treadmill exercise attenuated anxiety‐like behavior by decreasing inflammation response, exercise conferred a great benefit of attenuating anxiety‐like behavior via anti‐inflammatory treatment may prove to be a novel neuroprotective strategy for stroke.

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Section: Discussionmentioning

confidence: 99%

Proinflammatory cytokines correlate with early exercise attenuating anxiety‐like behavior after cerebral ischemia

Zhang

Yan

et al. 2017

Brain and Behavior

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“…Кроме того, де-прессия оказывает воздействие на функциональную ак-тивность тромбоцитов, вызывая их гиперактивацию, вы-званную повышенными уровнями фактора тромбоци-тов 4 и β-тромбоглобулина, увеличением содержания серотонина в тромбоцитах и снижением реактивности тромбоцитов в ответ на аденозинадифосфат [17,18]. Было высказано предположение, что гиперкортизоле-мия и повышенные уровни кортикотропин-рилизинг фактора могут быть дополнительными патофизиоло-гическими механизмами, связанными с негативным влиянием депрессии на исход ИБС.…”

Section: Antidepressants In Ischemic Heart Diseaseunclassified

“…Дан-ные ряда исследований показали, что связь между де-прессией и ИБС может быть обусловлена изменения-ми в иммунной системе и активацией маркеров вос-паления: так, пациенты с депрессией имеют более высокие уровни C-реактивного белка (СРБ) и цитоки-нов, которые играют важную роль в процессах атеро-генеза. Недавние исследования показали прямые ас-социации между уровнем депрессии и концентрации СРБ у пациентов, которые перенесли инфаркт миокарда [2,17,19]. Таким образом, можно утверждать, что ги-перактивация тромбоцитов, эндотелиальная дис-функция, активация воспалительных маркеров, а так-же нарушение сердечного ритма могут рассматри-ваться в качестве возможных связей между депресси-ей и ИБС [6].…”

Section: Antidepressants In Ischemic Heart Diseaseunclassified

Agomelatine in the Treatment of Anxiety and Depressive Disorders in Patients With Ischemic Heart Disease

Shimohina

Петрова

Савченко

et al. 2017

Racionalʹnaâ farmakoterapiâ v kardiologii

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“…This is the main reason why many researchers are involved in the investigations whether the neuron's FA pro¯le is di®erent in normal vs. psychopathological subjects (McNamara et al, 2014;Hamazaki et al, 2013;Yao & van Kammen, 2004). It should be noted here that, some researchers study the platelet FA pro¯le as a proxy instead of the neuron's FA pro¯le because, at least from the membrane FA pro¯le point of view, platelet dynamics is quite similar to that of neurons but much easier to investigate and manipulate (Mazereeuw et al, 2013;Cocchi et al, 2012). Of course, the measurement of FA composition has no direct bearing on the levels of neurotransmitters such as serotonin.…”

Section: Introductionmentioning

confidence: 99%

On the possible quantum role of serotonin in consciousness

Tonello

Cocchi

Gabrielli

et al. 2015

J. Integr. Neurosci.

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Cell membrane's fatty acids (FAs) have been carefully investigated in neurons and platelets in order to study a possible connection to psychopathologies. An important link between the FA distribution and membrane dynamics appears to emerge with the cytoskeleton dynamics. Microtubules (MTs) in particular have been implicated in some recent quantum consciousness models and analyses. The recently proposed quantum model of Craddock et al. (2014) states that MTs possess structural and functional characteristics that are consistent with collective quantum coherent excitations in the aromatic groups of their tryptophan residues. These excitations are consistent with a clocking mechanism on a sub-nanosecond scale. This mechanism and analogous phenomena in light-harvesting complexes in plants and bacteria, are induced by photons and have been touted as evidence of quantum processes in biology. A possible source of intra-cellular photons could be membrane lipid peroxidation processes, so the FA profile could then be linked to the bio-photon emission. The model presented here suggests new ways to understand the role serotonin plays in relation to FAs. In plants, tryptophan conversion of light to exciton energy can participate in the directional orientation of leaves toward sunlight. Since serotonin is structurally similar to tryptophan, in the human brain, neurons could use tryptophan to capture photons and also use serotonin to initiate movement toward the source of light. Hence, we postulate two possible new roles for serotonin: (1) as an antioxidant, in order to counter-balance the oxidative effect of FAs, and (2) to participate in quantum interactions with MTs, in the same way as anesthetics and psychoactive compounds have been recently shown to act. In this latter case, the FA profile could provide an indirect measure of serotonin levels.

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Platelet activating factors in depression and coronary artery disease: A potential biomarker related to inflammatory mechanisms and neurodegeneration

Cited by 40 publications

References 143 publications

Proinflammatory cytokines correlate with early exercise attenuating anxiety‐like behavior after cerebral ischemia

Proinflammatory cytokines correlate with early exercise attenuating anxiety‐like behavior after cerebral ischemia

Agomelatine in the Treatment of Anxiety and Depressive Disorders in Patients With Ischemic Heart Disease

On the possible quantum role of serotonin in consciousness

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