Abstract:Studies including ours have shown that pro‐oxidative stressors such as chemotherapeutic agents generate oxidized lipids with platelet‐activating factor (PAF) agonistic activity. These PAF‐agonists bind with and activate the widely‐expressed G‐protein coupled, PAF‐receptor (PAF‐R), implicated in various pathophysiological diseases including cancer. Notably, recent reports from our group have demonstrated that these PAF‐agonists are transported extracellularly via microvesicle particles (MVP). While the role of … Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.