Platelet activating factor enhances in vitro fertilization of rabbit oocytes

Roudebush, William E.; Minhas, Brijinder S.; Ricker, Deborah D.; Palmer, T.V.; Dodson, Melvin G.

doi:10.1016/0002-9378(90)90648-q

Cited by 49 publications

(19 citation statements)

References 17 publications

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“…This compound is a potent signaling phospholipid that is produced by and influences numerable cell types. PAF is involved in a number of reproductive and developmental processes (14,15), including ovulation (16), fertilization (17), preimplantation embryo development (18), implantation (19), and parturition (20). Embryos from a number of species produce PAF (15,21,22).…”

Section: Introductionmentioning

confidence: 99%

Influence of the Preimplantation Embryo Development (Ped) Gene on Embryonic Platelet-Activating Factor (PAF) Levels

Purnell

Warner

Kort

et al. 2006

J Assist Reprod Genet

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Section: Introductionmentioning

confidence: 99%

Influence of the Preimplantation Embryo Development (Ped) Gene on Embryonic Platelet-Activating Factor (PAF) Levels

Purnell

Warner

Kort

et al. 2006

J Assist Reprod Genet

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“…PAF is also found in spermatozoa [6], preimplanted embryos [7], amniotic fluid [8], and the uterus [9,10]. PAF is considered to be involved in a variety of reproductive processes including fertilization [11], implantation [12], and parturition [13]. The roles of PAF in parturition are not fully defined, but it is well documented that PAF induces myometrial contraction [14] and promotes the synthesis of prostaglandin E 2 [15].…”

Section: Introductionmentioning

confidence: 99%

Platelet-Activating Factor (PAF) and PAF Acetylhydrolase Activity in Rat Uterus and Placenta during the Late Stages of Pregnancy1

Matsubara

Yasuda

Johnston

et al. 1997

Biology of Reproduction

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We evaluated the roles of platelet-activating factor (PAF) and PAF-acetylhydrolase (PAF-AH) activity in late pregnancy. Uterine and placental concentrations of PAF were determined by the washed rabbit platelet aggregation bioassay. Uterine, placental, and plasma PAF-AH activities were also assayed. PAF concentration in the uterus increased 4-fold between Days 15 and 21 of pregnancy. PAF was also determined in the placenta on Days 15 and 21. In contrast to findings in the uterus, the concentration in the placenta was decreased by 75%. Platelet aggregation caused by uterine and placental PAF was inhibited by the PAF receptor antagonists CV-3988 and TCV-309. Plasma and uterine PAF-AH activities decreased significantly between Days 15 and 21. In contrast, the placental PAF-AH activity significantly increased during this same time period. On the basis of these findings, it is suggested that the PAF concentration in the uterus and placenta may be regulated by intracellular PAF-AH and/or plasma PAF-AH activities. Increased PAF activity in the pregnant rat uterus may be related to the initiation of labor due to its known effect on myometrial contraction. Decreased PAF concentration in the placenta may contribute to the fetoplacental circulation due to its known hypotensive activity and the increase in vascular permeability.

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“…PAF-acetyl hydrolase is present in seminal plasma and is believed to have a role as a decapacitation factor [Letendre et al, 1992]. The authors postulate that removal of this acetyl hydrolase during the capacitation process promotes PAF synthesis by the spermatozoa, which in turn may allow for increases in motility and sperm-egg interactions Minhas et al, 1989;Roudebush et al, 1990Roudebush et al, , 1993Kuzan et al, 1990;Hellstrom et al, 1991;Angle et al, 1989]. In this study, capacitation was not promoted since no capacitating-inducible agents (e.g., bovine serum albumin and dibutyryl cyclic adenosine monophosphate) were added.…”

Section: Discussionmentioning

confidence: 96%

“…PAF plays a significant role in the fertilization process, enhancing the in vitro fertilization rates of murine Sengoku et al, 1992] and rabbit [Roudebush et al, 1990[Roudebush et al, , 1993 oocytes, while PAF antagonists inhibit fertilization Kuzan et al, 1990]. Endogenous PAF (spermatozoal origin) will increase murine in vitro fertilization [Kuzan et al, 1990].…”

Section: Discussionmentioning

confidence: 98%

Presence of platelet‐activating factor in squirrel monkey ( Saimiri boliviensis ) spermatozoa: seasonal differences

Roudebush

Mathur

1998

American J Primatol

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Platelet‐activating factor (1‐O‐alkyl‐2‐acetyl‐sn‐glycero‐3‐phosphorylcholine) (PAF) is a potent signaling phospholipid which has pleiotropic biological properties in addition to platelet activation. PAF has been detected in the spermatozoa in a number of species. The concentration of PAF is inversely related to human spermatozoal quality. There are no reports on the presence of PAF in nonhuman primate spermatozoa. Therefore, the primary objective of this study was to determine if PAF is present in the spermatozoa from the squirrel monkey (which is a seasonal breeder). A second objective was to determine if PAF levels change from the breeding to the nonbreeding season. Endogenous lipids were extracted from mature Bolivian squirrel monkeys (Saimiri boliviensis) spermatozoa and assayed for the presence of PAF by [125I] radioimmunoassay. PAF was detected in all samples assayed. PAF levels were significantly higher (P< 0.01) during the breeding season (mean: 3.58 ng/106 spermatozoa) than the nonbreeding season (mean: 0.76 ng/106 spermatozoa). The data demonstrate that PAF is present in squirrel monkey spermatozoa, with higher levels found during the breeding season. Additional studies are warranted to elucidate the role of PAF in spermatozoa function. Am. J. Primatol. 45:301–305, 1998. © 1998 Wiley‐Liss, Inc.

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Platelet activating factor enhances in vitro fertilization of rabbit oocytes

Cited by 49 publications

References 17 publications

Influence of the Preimplantation Embryo Development (Ped) Gene on Embryonic Platelet-Activating Factor (PAF) Levels

Influence of the Preimplantation Embryo Development (Ped) Gene on Embryonic Platelet-Activating Factor (PAF) Levels

Platelet-Activating Factor (PAF) and PAF Acetylhydrolase Activity in Rat Uterus and Placenta during the Late Stages of Pregnancy1

Presence of platelet‐activating factor in squirrel monkey ( Saimiri boliviensis ) spermatozoa: seasonal differences

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