Platelet abnormalities in ischemic heart disease

Salky, N; Dugdale, Marion

doi:10.1016/s0002-9149(73)80053-0

Cited by 114 publications

(21 citation statements)

References 29 publications

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“…G o ld en fa rb et al [3] found increased ADP-induced platelet aggregation among patients surviving myocardial infarction. Salky and D u g d a le [23] found normal platelet aggregation among patients with ischemic heart disease when tested with ADP, but increased aggregability when tested with collagen. Steele et al [24] ob served normal ADP-induced platelet aggregability among patients with angiographically documented coronary artery disease, whereas F rish m a n et al [2] recently reported increased platelet aggregability among their patients with angina pectoris when tested with ADP.…”

Section: Exercise Testmentioning

confidence: 99%

Effects of Exercise-Induced Stress on Platelet Aggregation

Levites¹,

Haft²

1975

Cardiology

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In order to determine if the stress of a standard exercise test wil affect the propensity for platelets to aggregate, platelet aggregometer studies were performed before and after a double two-step Master’s test in 19 patients with angina and in 19 normal controls. The response of platelet-rich plasma to 0.1, 1 and 10 µMof ADP and 1 and 10 µMof epinephrine were tested in a Chrono-Log aggregometer. Prior to exercise there was no significant difference between the number of patients and controls responding with irreversible aggregation to any of the five tests. Immediately following exercise, no significant differences in the number of irreversible aggregation responses were seen in the control group. In the group with coronary artery disease, the incidence of irreversible responses was significantly higher after exercise on test with 1 µM ADP (p < 0.05), 1 µM epinephrine (p = 0.02), and 10 µM epinephrine (p < 0.05). It is concluded that exercise increases significantly the tendency of platelets to aggregate among patients with coronary artery disease. It is possible that this effect may play a role in myocardial infarction induced during stress.

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Section: Exercise Testmentioning

confidence: 99%

Effects of Exercise-Induced Stress on Platelet Aggregation

Levites¹,

Haft²

1975

Cardiology

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“…Increased incidence of shortened platelet survival time [1.2] and in vitro platelet hyperresponsiveness [2,3] have been observed in patients with coronary artery disease (CAD). Platelet aggregates may be responsible for the occlusion of small or narrowed coronary vessels with consecutive acute or chronic myocardial ischemia and sudden death [4].…”

Section: ____________________________________________________________mentioning

confidence: 99%

Plasma Concentrations of Platelet-Specific Proteins in Coronary Artery Disease

Mühlhauser¹,

Schernthaner²,

Silberbauer³

et al. 1981

Cardiology

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The plasma concentrations of β-thromboglobulin (β-TG) and platelet factor 4 (PF4) were measured in 100 patients with documented coronary artery disease (CAD) and in 40 controls. 18 patients had had coronary artery bypass surgery (CABS), 25 patients were on therapy with β-blocking agents and 19 were treated with oral anticoagulants. 38 patients with CAD received neither CABS nor β-blocking or anticoagulating drugs. The highest plasma concentrations of β-TG and PF4 were found in the patient group without medical or surgical treatment (patients versus controls: p < 0.01). Patients with CABS showed β-TG and PF4 levels within the normal range. Patients with β-blocking agents also had lower β-TG and PF4 values than the patient group without therapy (p < 0.05). By contrast, patients on oral anticoagulation therapy presented with similar plasma concentrations of β-TG and PF4 as untreated patients. Our data indicate that surgical or medical treatment with β-blocking agents, but not with oral anticoagulants, may have some influence on platelet function in patients with CAD. β-TG and PF4 radioimmunoassay may be a simple method to study platelet involvement in various diseases and to evaluate possible influences of medical or surgical treatment on in vivo platelet function.

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“…(Arteriosclerosis 3:138-140, March/April 1983) T he platelet survival time has been reported to be shortened in 50% to 65% of patients with symptomatic coronary atherosclerosis. 1 " 4 We performed platelet survival studies as part of the initial evaluation of the effects of antiplatelet drugs in patients with stable effort angina pectoris and found fewer than one-third with shortened platelet survival times. This unexpected low incidence is explained by the finding that platelet survival times were decreased less often in our black than in our white patients.…”

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confidence: 99%

Racial differences in platelet survival time in patients with symptomatic coronary atherosclerosis.

Thomas¹,

Giles²,

Stuckey³

et al. 1983

Arteriosclerosis

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Platelet survival times were studied in 40 patients (21 white and 19 black) with coronary artery disease and stable effort induced angina pectoris. The platelet survival times of 19 white controls (9.27 ± 0.49 days; mean ± SD) were not significantly different from those of 12 black controls (8.88 ± 0.81 days), and the platelet survival times for 21 white patients with coronary artery disease (8.46 ± 0.65 days) were lower than the times for both the white controls (p < 0.01) and the combined control group (p < 0.01). However, the difference between the mean platelet survival times of 19 black patients (9.22 ± 0.68) and the control groups was not significant, and the difference between the mean platelet survival times of the 21 white patients and the 19 black patients was significant (p < 0.01). Stepwise multiple linear regression analysis indicated that race was the most significant factor in predicting shortened platelet survival (r = 0.4783; p < 0.01). It is concluded that racial background should be considered in the interpretation of platelet studies and that reported racial differences in the rate and extent of atherosclerotic lesions may be related to racial differences in platelet consumption. (Arteriosclerosis 3:138-140, March/April 1983) T he platelet survival time has been reported to be shortened in 50% to 65% of patients with symptomatic coronary atherosclerosis. 1 " 4 We performed platelet survival studies as part of the initial evaluation of the effects of antiplatelet drugs in patients with stable effort angina pectoris and found fewer than one-third with shortened platelet survival times. This unexpected low incidence is explained by the finding that platelet survival times were decreased less often in our black than in our white patients. Methods Platelet Survival TestingOne unit of autologous platelets was collected, labelled with 150 to 200 ju.C of Na 2 51 CrO4, washed, and reinfused into the subject according to the method of Aster as modified by Harker.5 Blood samples were collected into disodium edatate anticoagulant daily for 7 to 9 days, and the platelets were extracted by differential centrifugation. Platelet radioactivity was measured in a well-type gamma counter, and a weighted platelet survival time was determined using a computer program based on a linear-exponential model of platelet disappearance. 6 Platelet survival times were studied in 31 control subjects. All were believed to be in good health and were taking no medication. Twelve controls were black (10 males; 2 females) and 19 were white (16 males; 2 females). Smoking history and serum cholesterol and triglyceride values were recorded.Forty outpatients volunteered for the study. All patients met the criteria of the New York Heart Association for stable effort angina pectoris. All had treadmill exercise tests which produced ischemic ST segment response, and coronary arteriograms which showed greater than 50% luminal diameter narrowing of one or more coronary arteries. No patients were taking drugs known to affect platelet funct...

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Platelet abnormalities in ischemic heart disease

Cited by 114 publications

References 29 publications

Effects of Exercise-Induced Stress on Platelet Aggregation

Effects of Exercise-Induced Stress on Platelet Aggregation

Plasma Concentrations of Platelet-Specific Proteins in Coronary Artery Disease

Racial differences in platelet survival time in patients with symptomatic coronary atherosclerosis.

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