Platelet 3H-imipramine binding in bipolar patients

Muscettola, Giovanni; Lauro, Andrea Di; Giannini, Clemente Patrizio

doi:10.1016/0165-1781(86)90019-3

Cited by 34 publications

(6 citation statements)

References 30 publications

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“…An exemplary summary of some platelet markers indicates that some, though not all, do show significant changes in different physiological states (table 1). In contrast, nine studies report no differences 22,30,31,40,43,45,72,113,119. MAO is lower in men than in women 71, 9o, 127, is lower during the premenstrual phase and lower in pregnancy and post-partum 127.…”

Section: 'Normal' Variabilitymentioning

confidence: 93%

Platelet research in psychiatry

Wirz‐Justice

1988

Experientia

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The platelet is one of the most researched biological markers in psychiatry. Characteristics of MAO activity, 5-HT uptake, imipramine and alpha 2-adrenergic receptor binding, for example, are similar in platelet and CNS. Methodological factors are not negligible, and range from diagnostic specificity and drug effects to the normal physiological variability of age and hormone-related changes, circadian and seasonal rhythms. As yet, there are no clear state or trait platelet markers in affective disorders and schizophrenia that can be unequivocally used to detect vulnerability to the illness, predict therapeutic response, define clinical diagnostic entities or follow the course of the illness. However, platelet markers are increasingly being used in careful studies to monitor psychopharmacological effects (an in vivo assay of all active metabolites), different ligands can be specific markers for certain aspects of a psychiatric illness (e.g. alpha 2-adrenergic receptors and weight loss), and this homogeneous preparation of human cells is an increasingly important tool in studying mechanisms in pathophysiology. More longitudinal studies are required to establish functional relationships between platelet variables and psychopathology.

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Section: 'Normal' Variabilitymentioning

confidence: 93%

Platelet research in psychiatry

Wirz‐Justice

1988

Experientia

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“…[27] showed a significant decrease, Berrettini et al [7], Muscettola et al [26] and Desmedt et al [12] found no significant difference in Bmax values in bipolar patients compared to controls while Mellerup et al [23] reported a weak but significant increase in 'manic-melancholic' patients. In addition, the bipolar patients tested in a manic or euthymie state also had very low Bmax values, which concurs with the data found by Baron et al [5].…”

Section: Discussionmentioning

confidence: 99%

“…However, out of the 36 studies published, only Mellerup et al [23] reported a small but significant increase in Bmax in 'manic-melancholic' pa tients, while 12 studies failed to detect any differences between untreated patients and controls. In the 23 stud ies concurring with a decrease in Bmax, quantitative dif ferences exist which vary from a 10% to a 54% decrease in the mean Bmax values in depressed subjects [for reviews see 6, 21, 24], Several experimental and clinical variables have in turn been evoked to explain these dis crepancies in results, such as methodological differences with regard to cell isolation, membrane homogenate preparation or platelet storage, ligand or protein concen trations used, heterogeneity of the depressed population, and length of the washout period [20,24,26,31,36].…”

Section: Introductionmentioning

confidence: 99%

Platelet [<sup>3</sup>H]-Imipramine Binding according to DSM-III Subtypes of Depression

Jeanningros¹,

Gronier²,

Azorin³

et al. 1989

Neuropsychobiology

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The question of the previously reported changes in the density of high-affinity binding sites for [³H]-imipramine (IMI) in platelets from depressed patients was reexamined among the different diagnostic subtypes of depression according to the DSM-III classification and taking into account the possible influence of the low-affinity binding site. Using a least-square computer-assisted analysis, a precise determination of the [³H]-IMI binding parameters exclusively in relationship to the high-affinity site was performed in 46 untreated depressed patients and compared to 35 healthy controls. The results revealed a clear and highly significant 22% decrease in the maximal density (B_max) of [³H]-IMI binding in all of the depressed patients compared to controls with no change in affinity values. Considering the diagnostic subgroups, we found that all the bipolar patients, the depressed as well as the euthymic or manic ones, had very low B_max values and that some of them also exhibited an unusual low-affinity binding. Mean B_max of the unipolar and dysthymic patients significantly decreased when compared to controls, although the B_max values showed a large variability. Only dysthymic patients presented B_max values which were significantly associated to symptom severity as assessed by the Hamilton Depression Rating Scale scores. Our results confirm the lower density of platelet [³H]-IMI binding in affective disorders, particularly in bipolar patients, and also suggest that this biological parameter is a trait marker in bipolar depression and a state marker in dysthmic disorder.

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“…The binding affinity of this site to imipramine in platelets has been examined to gain information about 5-HT neuron function in manic patients. Of the four studies that examined imipramine binding in manic patients, two showed an increase (55,56), while the other two showed no difference (57,58) in binding in manics compared to depressed patients. However, all four studies reported that binding was not different in manics when compared to healthy controls.…”

Section: Platelet Studiesmentioning

confidence: 96%

Serotonin in mania and in the mechanism of action of mood stabilizers: a review of clinical studies

Shiah

Yatham

2000

Bipolar Disorders

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There is some evidence from clinical studies for the contribution of 5-HT in mania and in the mechanism of action of mood stabilizers. However, it is very likely that other neurotransmitters also play important roles. Future directions for research include 1) in vivo study of 5-HT receptor subtypes using positron emission tomography, 2) investigation of the interaction between 5-HT and other neurotransmitter systems, and 3) determination of the relationships between diagnostic subtypes of mania and 5-HT function and other neurotransmitter systems.

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Platelet 3H-imipramine binding in bipolar patients

Cited by 34 publications

References 30 publications

Platelet research in psychiatry

Platelet research in psychiatry

Platelet [<sup>3</sup>H]-Imipramine Binding according to DSM-III Subtypes of Depression

Serotonin in mania and in the mechanism of action of mood stabilizers: a review of clinical studies

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