Mandibular defects caused by disease, congenital, or other causes affect the patient's quality of life, and mandibular reconstruction is important to restore the functional and aesthetic aspects. Particulate-cancellous bone marrow (PCBM) as the grafting material of the reconstruction offers promising outcomes with fewer surgical complication risks. However, a stable mechanical environment is required for effective healing, while implant failures are still encountered. This paper explores tissue differentiation during mandibular reconstruction with PCBM graft healing using biphasic mechanoregulation theory under four bite force magnitudes and four implant elastic moduli to examine its implication on healing rate, implant stress distribution, and various biomechanical properties. The numerical model used in this study was a half Canis lupus mandible, symmetrical about the midsagittal plane, with two marginal defects in which filled by PCBM graft and stabilized by porous implants. The results showed bone tissue origin and propagation to the experimental findings, where it propagates from the superior side and the buccal and lingual sides in contact with the native bone, starting from the outer regions and progressing inward. Faster healing and quicker development of bone graft elastic modulus and mandible equivalent stiffness were observed in the variants with lower bite force magnitude and or larger implant elastic modulus. A load-sharing condition was found as the healing progressed. This study has implications for a better understanding of mandibular reconstruction mechanobiology and demonstrated a novel in silico framework that can be used for post-operative planning and implant design.