Plastin 1 drives metastasis of colorectal cancer through the IQGAP1/Rac1/ERK pathway

Zhang, Tongtong; Wang, Zheng; Liu, Yanjun; Huo, Yongxu; Liu, Hongtao; Xu, Chang; Mao, Rui; Zhu, Yongping; Liu, Lei; Wei, Danfeng; Liu, Guanzhi; Pan, Biran; Tang, Yan; Zhou, Zheng; Yang, Cheng; Guo, Yuanbiao

doi:10.1111/cas.14438

Cited by 24 publications

(14 citation statements)

References 38 publications

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“…We have further found that diallyl disulfide (DADS) inhibits the migration and invasion of colorectal cancer cell line SW480 by regulating the Rac1-ROCK1/PAK1-LIMK1-ADF/cofilin signaling pathway (104,105). Zhang, et al found that Plastin1 (PLS1), which is related to the microvilli structure of the intestinal epithelium, drives the metastasis of colorectal cancer through the IQGAP1-Rac1-ERK pathway (106). Overexpression of phospholipid phosphataserelated protein 1 (PLPPR1) in the mouse neuroblastoma cell line (Neuro2a) reduces the level of active Rac1.…”

Section: Rac1 Participates In Tumor Migration and Invasionmentioning

confidence: 94%

Rac1, A Potential Target for Tumor Therapy

et al. 2021

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RAS-related C3 botulinum toxin substrate 1 (Rac.1) is one of the important members of Rho GTPases. It is well known that Rac1 is a cytoskeleton regulation protein that regulates cell adhesion, morphology, and movement. Rac1 is highly expressed in different types of tumors, which is related to poor prognosis. Studies have shown that Rac1 not only participates in the tumor cell cycle, apoptosis, proliferation, invasion, migration and angiogenesis, but also participates in the regulation of tumor stem cell, thus promoting the occurrence of tumors. Rac1 also plays a key role in anti-tumor therapy and participates in immune escape mediated by the tumor microenvironment. In addition, the good prospects of Rac1 inhibitors in cancer prevention and treatment are exciting. Therefore, Rac1 is considered as a potential target for the prevention and treatment of cancer. The necessity and importance of Rac1 are obvious, but it still needs further study.

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Section: Rac1 Participates In Tumor Migration and Invasionmentioning

confidence: 94%

Rac1, A Potential Target for Tumor Therapy

et al. 2021

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“…PLS1 (plastin 1) is one of the actin-binding protein family members that are conserved throughout eukaryote evolution. PLS1 drives metastasis of colorectal cancer through the IQGAP1/Rac1/ERK pathway ( Zhang et al, 2020 ) and promotes osteoblast differentiation by regulating intracellular Ca2+ ( Wang L. et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Prediction of a Competing Endogenous RNA Co-expression Network by Comprehensive Methods in Systemic Sclerosis-Related Interstitial Lung Disease

Yan

Zheng

et al. 2021

Front. Genet.

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Systemic sclerosis (SSc) is an immune-mediated connective tissue disease characterized by fibrosis of multi-organs, and SSc-related interstitial lung disease (SSc-ILD) is a leading cause of morbidity and mortality. To explore molecular biological mechanisms of SSc-ILD, we constructed a competing endogenous RNA (ceRNA) network for prediction. Expression profiling data were obtained from the Gene Expression Omnibus (GEO) database, and differential expressed mRNAs and miRNAs analysis was further conducted between normal lung tissue and SSc lung tissue. Also, the interactions of miRNA–lncRNA, miRNA–mRNA, and lncRNA–mRNA were predicted by online databases including starBase, LncBase, miRTarBase, and LncACTdb. The ceRNA network containing 11 lncRNAs, 7 miRNAs, and 20 mRNAs were constructed. Based on hub genes and miRNAs identified by weighted correlation network analysis (WGCNA) method, three core sub-networks—SNHG16, LIN01128, RP11-834C11.4(LINC02381)/hsa-let-7f-5p/IL6, LINC01128/has-miR-21-5p/PTX3, and LINC00665/hsa-miR-155-5p/PLS1—were obtained. Combined with previous studies and enrichment analyses, the lncRNA-mediated network affected LPS-induced inflammatory and immune processes, fibrosis development, and tumor microenvironment variations. The ceRNA network, especially three core sub-networks, may be served as early biomarkers and potential targets for SSc, which also provides further insights into the occurrence, progression, and accurate treatment of SSc at the molecular level.

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“…Taking advantage of in vivo experiments, it was shown that thiopurines treatments (TG) inhibited CAC in the AOM/DSS mouse model, via decreased β-catenin in a RAC1-dependent mechanism [ 144 ]. In the context of epithelial cell targeting, EMT and metastatic potential might be inhibited upon activation of RAC1; for instance, upon CSRP2 treatment (Hippo-ERK-PAK/LIMK/cortactin) [ 145 ], miR-142-3p transfection [ 146 ], upregulation of SSH3 (LIMK) [ 147 ] or PLS1 (ERK1/2) [ 148 ], downregulation of DMTN [ 149 ], or IRF1 suppression [ 150 ]. Recent work from An et al revealed the different behavior of RAC1 inhibition in combination with irradiation on cell cycle.…”

Section: Rac1 (Ras-related C3 Botulinum Toxin Substrate 1)mentioning

confidence: 99%

Rho GTPases as Key Molecular Players within Intestinal Mucosa and GI Diseases

Pradhan

Ngo

Martínez-Sánchez

et al. 2021

Cells

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Rho proteins operate as key regulators of the cytoskeleton, cell morphology and trafficking. Acting as molecular switches, the function of Rho GTPases is determined by guanosine triphosphate (GTP)/guanosine diphosphate (GDP) exchange and their lipidation via prenylation, allowing their binding to cellular membranes and the interaction with downstream effector proteins in close proximity to the membrane. A plethora of in vitro studies demonstrate the indispensable function of Rho proteins for cytoskeleton dynamics within different cell types. However, only in the last decades we have got access to genetically modified mouse models to decipher the intricate regulation between members of the Rho family within specific cell types in the complex in vivo situation. Translationally, alterations of the expression and/or function of Rho GTPases have been associated with several pathological conditions, such as inflammation and cancer. In the context of the GI tract, the continuous crosstalk between the host and the intestinal microbiota requires a tight regulation of the complex interaction between cellular components within the intestinal tissue. Recent studies demonstrate that Rho GTPases play important roles for the maintenance of tissue homeostasis in the gut. We will summarize the current knowledge on Rho protein function within individual cell types in the intestinal mucosa in vivo, with special focus on intestinal epithelial cells and T cells.

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Plastin 1 drives metastasis of colorectal cancer through the IQGAP1/Rac1/ERK pathway

Cited by 24 publications

References 38 publications

Rac1, A Potential Target for Tumor Therapy

Rac1, A Potential Target for Tumor Therapy

Prediction of a Competing Endogenous RNA Co-expression Network by Comprehensive Methods in Systemic Sclerosis-Related Interstitial Lung Disease

Rho GTPases as Key Molecular Players within Intestinal Mucosa and GI Diseases

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