Plasticizers in the manufacture of novel skin-bioadhesive patches

Adhesive properties: a critical issue in transdermal patch development

“…These data were recently used to elaborate skin models for adhesion test, which kept into account the skin deformability [22,[70][71][72] and rugosity [73,74].…”

Plasticizers in Transdermal Drug Delivery Systems

“…These molecules can more easily penetrate between the polymer chains of the film forming agent and can interact with the specific functional groups of the polymer (Gal & Nussinovitch, 2009). …”

“…By adding plasticizer to a polymeric material, elongation at break, toughness and flexibility are expected to increase, on the other hand tensile stress, hardness, electrostatic chargeability, Youngs modulus and glass transition temperature are expected to decrease (Gal & Nussinovitch, 2009;Harper, 2006;Rahman & Brazel, 2004).…”

“…hydrogen bond) of the polymer chains and themselves forming secondary bonds (Gal & Nussinovitch, 2009). While low molecular weight improves miscibility with the polymer, the second factor increasing the compatibility is the realization of strong mutual hydrogen bonding (Harper, 2006).…”

“…The chemical formulas of 6 plasticizers frequently used in transdermal drug delivery studies are given in Among the plasticizers commonly used in the formulation of transdermal films, there are the phthalate and citrate esters and glycol derivatives (Gal & Nussinovitch, 2009). The plasticizers used in the studies conducted through last 20 years, their proportions and the polymers they are used with are given as a table (Table 3).…”