Plasticization and antiplasticization of an acrylic pressure sensitive adhesive by ibuprofen and their effect on the adhesion properties

Michaelis, Marc; Brummer, R.; Leopold, Claudia

doi:10.1016/j.ejpb.2013.07.005

Cited by 46 publications

(26 citation statements)

References 30 publications

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“…An unusual behaviour, which was attributed to antiplasticization, has been reported by Michelis et al [152] in studies of the effects of ibuprofen as a plasticizer for a proprietary acrylic pressure sensitive adhesive, which has a Tg in the region of −22 • C. An increase in both storage and loss modulus, as well as an augmentation of the "probe tack" stress value measured at 21 • C, was observed at 1 wt.% level of addition. The striking anomaly in the findings of this work was in respect to the antiplasticization effect (expressed as in increase in stiffness), which was observed within the rubbery state at a temperature well above the Tg.…”

Section: Unusual Feature Of Antiplasticizationsupporting

confidence: 59%

Antiplasticization of Polymer Materials: Structural Aspects and Effects on Mechanical and Diffusion-Controlled Properties

et al. 2020

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Antiplasticization of glassy polymers, arising from the addition of small amounts of plasticizer, was examined to highlight the developments that have taken place over the last few decades, aiming to fill gaps of knowledge in the large number of disjointed publications. The analysis includes the role of polymer/plasticizer molecular interactions and the conditions leading to the cross-over from antiplasticization to plasticization. This was based on molecular dynamics considerations of thermal transitions and related relaxation spectra, alongside the deviation of free volumes from the additivity rule. Useful insights were gained from an analysis of data on molecular glasses, including the implications of the glass fragility concept. The effects of molecular packing resulting from antiplasticization are also discussed in the context of physical ageing. These include considerations on the effects on mechanical properties and diffusion-controlled behaviour. Some peculiar features of antiplasticization regarding changes in Tg were probed and the effects of water were examined, both as a single component and in combination with other plasticizers to illustrate the role of intermolecular forces. The analysis has also brought to light the shortcomings of existing theories for disregarding the dual cross-over from antiplasticization to plasticization with respect to modulus variation with temperature and for not addressing failure related properties, such as yielding, crazing and fracture toughness.

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Section: Unusual Feature Of Antiplasticizationsupporting

confidence: 59%

Antiplasticization of Polymer Materials: Structural Aspects and Effects on Mechanical and Diffusion-Controlled Properties

et al. 2020

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“…The bonding of PSA occurs at low frequencies and the PSA has to be more liquid-like since it must wet the substrate. The debonding process occurs at high frequencies and requires a solid-like behavior 11 . Therefore, at low frequencies G ″ should be predominate and at high frequencies G ′ should be dominant.…”

Section: Resultsmentioning

confidence: 99%

“…The adhesion performance of patches is strongly dependent on the viscoelastic properties of the adhesive 7 . Several reports have focused on rheological studies to characterize the viscoelastic properties of PSA, and the effect of drug and penetration enhancers on the viscoelastic properties of PSAs has been studied 8 , 9 , 10 , 11 . As the viscoelastic nature of PSA controls the adhesion performance and affects the drug-release properties of transdermal patches, changes in the performance of patches can be attributed to a change in viscoelastic nature of PSA.…”

Section: Introductionmentioning

confidence: 99%

Effect of isopropyl myristate on the viscoelasticity and drug release of a drug-in-adhesive transdermal patch containing blonanserin

Zhao

Quan

Liu

et al. 2016

Acta Pharmaceutica Sinica B

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The purpose of this study was to investigate the effect of isopropyl myristate (IPM), a penetration enhancer, on the viscoelasticity and drug release of a drug-in-adhesive transdermal patch containing blonanserin. The patches were prepared with DURO-TAK® 87-2287 as a pressure-sensitive adhesive (PSA) containing 5% (w/w) of blonanserin and different concentrations of IPM. An in vitro release experiment was performed and the adhesive performance of the drug-in-adhesive patches with different concentrations of IPM was evaluated by a rolling ball tack test and a shear-adhesion test. The glass transition temperature (Tg) and rheological parameters of the drug-in-adhesive layers were determined to study the effect of IPM on the mechanical properties of the PSA. The results of the in vitro release experiment showed that the release rate of blonanserin increased with an increasing concentration of IPM. The rolling ball tack test and shear-adhesion test showed decreasing values with increasing IPM concentration. The results were interpreted on the basis of the IPM-induced plasticization of the PSA, as evidenced by a depression of the glass transition temperature and a decrease in the elastic modulus. In conclusion, IPM acted as a plasticizer on DURO-TAK® 87-2287, and it increased the release of blonanserin and affected the adhesive properties of the PSA.

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“…A variety of product and process variables are likely to affect the adhesive and cohesive properties of DIA‐TDDS . For example, the increased drug load in acrylic PSA has been reported to decrease the shear adhesion properties of ibuprofen TDDS . Similarly increased drug loads of potassium diclofenac and nicotine have been reported to cause a reduction in the shear adhesion properties of TDDS containing polyacrylates .…”

Section: Discussionmentioning

confidence: 99%

“…13,18 For example, the increased drug load in acrylic PSA has been reported to decrease the shear adhesion properties of ibuprofen TDDS. 19 Similarly increased drug loads of potassium diclofenac and nicotine have been reported to cause a reduction in the shear adhesion properties of TDDS containing polyacrylates. 20 The presence of penetration enhancers in TDDS has been reported to affect the cohesive and adhesive properties of TDDS.…”

Section: Cold Flow Induction Timementioning

confidence: 95%

Stereomicroscopic Imaging Technique for the Quantification of Cold Flow in Drug-in-Adhesive Type of Transdermal Drug Delivery Systems

Krishnaiah

Katragadda

Khan

2014

Journal of Pharmaceutical Sciences

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Plasticization and antiplasticization of an acrylic pressure sensitive adhesive by ibuprofen and their effect on the adhesion properties

Cited by 46 publications

References 30 publications

Antiplasticization of Polymer Materials: Structural Aspects and Effects on Mechanical and Diffusion-Controlled Properties

Antiplasticization of Polymer Materials: Structural Aspects and Effects on Mechanical and Diffusion-Controlled Properties

Effect of isopropyl myristate on the viscoelasticity and drug release of a drug-in-adhesive transdermal patch containing blonanserin

Stereomicroscopic Imaging Technique for the Quantification of Cold Flow in Drug-in-Adhesive Type of Transdermal Drug Delivery Systems

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