Plasticity of visual evoked potentials in patients with neurofibromatosis type 1

Castricum, Jesminne; Tulen, Joke H.M.; Heuvelmans, A.M.; Geleijnse, G.; Straver, D.C.G.; Kushner, Steven A.; Elgersma, Ype

doi:10.1016/j.clinph.2022.08.009

Cited by 2 publications

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“…Nevertheless, we did observe significant changes in the eye movement responses and hand accuracy of the NF1 group. The sample size was similar to previous studies that could indicate differences in eye movement responses between a neurological disorder and control behaviour (Verheij et al 2012;Muilwijk et al 2013) and to a previous study investigating visual information in NF1 adults showing reduced visual cortical plasticity (Castricum, Tulen, Heuvelmans, et al 2022).…”

Section: Discussionsupporting

confidence: 72%

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Visual–spatial and visuomotor functioning in adults with neurofibromatosis type 1

Castricum

Tulen

Pel

et al. 2023

J intellect Disabil Res

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Background Neurofibromatosis type 1 (NF1) is a neurodevelopmental genetic disorder associated with visual-spatial and visuomotor deficits, which have not been studied well in adults with NF1. Methods In 22 adults with NF1 and 31 controls, visuomotor functioning was assessed by measuring eye latency, hand latency and hand accuracy during visuomotor tasks. Visual-spatial functioning was assessed by measuring eye movement responses during the Visual Threshold Task. Results The NF1 group had a significantly shorter eye latency than the control group and was less accurate in their hand movements during specific visuomotor tasks. The groups showed no differences in eye movement responses during the Visual Threshold Task and in hand latency during the visuomotor tasks. Conclusions In contrast to studies in children with NF1, we found no alterations in visual-spatial information processing in adults. Impairments in eye latency and hand accuracy during specific visuomotor tasks may indicate deficits in visuomotor functioning in adults with NF1.

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Section: Discussionsupporting

confidence: 72%

“…2013) and to a previous study investigating visual information in NF1 adults showing reduced visual cortical plasticity (Castricum, Tulen, Heuvelmans, et al . 2022).…”

Section: Discussionmentioning

confidence: 99%

Visual–spatial and visuomotor functioning in adults with neurofibromatosis type 1

Castricum

Tulen

Pel

et al. 2023

J intellect Disabil Res

Self Cite

View full text Add to dashboard Cite

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Analysis of visual evoked potentials in patients with neurofibromatosis type 1: new concepts

Jancic,

Zarkovic,

Nikolic

et al. 2024

Front. Neurol.

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IntroductionNeurofibromatosis type 1 (NF type 1) is an autosomal dominant disease with typical clinical manifestations, such as skin lesions, Lisch nodules, optic pathway gliomas, and neurofibromas, caused by the mutation of the NF1 gene. Visual evoked potentials (VEP) present a measure of the electrophysiological response of visual cortex to a visual stimulus. The role of VEP in the pathophysiology of NF type 1 is very complex and requires additional research.The AimWe examined the differences between NF type 1 patients with normal and altered VEP and analyzed the correlation between the prolongation of P100 latency and disease severity.Materials and methodsTwo groups were formed: a control group and a study group with NF type 1 patients. Based on the control group analysis, a threshold value for a normal VEP finding of 116 ms was obtained, and it was used to divide the study group into subgroups with normal and altered VEP. We proceeded with examining the differences in clinical manifestations of the disease between the subgroups, after which we checked if there is a correlation between the prolongation of the P100 latency and the severity of the clinical picture according to the Riccardi scale. Statistical analysis was performed using the Pearson chi-square test and the Spearman correlation test in the program SPSS 28.0, with levels of statistical significance p = 0.05 and p = 0.001.ResultsIn the group with the abnormal VEP we found a statistically significant more frequent occurrence of optic tract glioma (p = 0.008), tumors (p = 0.032), epilepsy (p = 0.043), and cognitive disorders (p = 0.028), while the other clinical signs had an equal prevalence in both groups. A moderately strong correlation (rs = 0.665) was observed between the prolongation of P100 latency and the severity of the clinical picture.ConclusionOur results showed the important role of VEP in the description of clinical phenotypes of NF type 1. The authors of the study propose VEP to be included in the diagnostic algorithms designed for patients with NF type 1.

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Plasticity of visual evoked potentials in patients with neurofibromatosis type 1

Cited by 2 publications

References 44 publications

Visual–spatial and visuomotor functioning in adults with neurofibromatosis type 1

Visual–spatial and visuomotor functioning in adults with neurofibromatosis type 1

Analysis of visual evoked potentials in patients with neurofibromatosis type 1: new concepts

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