Plasticity of the histamine H3 receptors after acute vestibular lesion in the adult cat

Tighilet, Brahim; Mourre, Christiane; Lacour, Michel

doi:10.3389/fnint.2013.00087

Cited by 14 publications

(6 citation statements)

References 101 publications

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“…Therefore, Arc-IR cells in the ipsilateral SpVN after UL may have some influence on UL-induced vestibulospinal deficits. Tighilet et al reported that downregulation of histamine H3 receptors in the medial vestibular nucleus after UL could facilitate GABA release from cerebellar inputs and inhibitory interneurons that make synaptic contacts with second-order neurons; alternatively, it could facilitate glutamate release from the terminals of second-order MVN neurons that synapse on inhibitory interneurons in the contralateral MVN [28]. Modulation of GABAergic and glutamatergic neurons by H3 receptors should restore the balance between the vestibular nuclei on both sides.…”

Section: Discussionmentioning

confidence: 99%

Vestibular Compensation after Vestibular Dysfunction Induced by Arsanilic Acid in Mice

et al. 2019

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When vestibular function is lost, vestibular compensation works for the reacquisition of body balance. For the study of vestibular dysfunction and vestibular compensation, surgical or chemical labyrinthectomy has been performed in various animal species. In the present study, we performed chemical labyrinthectomy using arsanilic acid in mice and investigated the time course of vestibular compensation through behavioral observations and histological studies. The surgical procedures required only paracentesis and storage of 50 µL of p-arsanilic acid sodium salt solution in the tympanic cavity for 5 min. From behavioral observations, vestibular functions were worst at 2 days and recovered by 7 days after surgery. Spontaneous nystagmus appeared at 1 day after surgery with arsanilic acid and disappeared by 2 days. Histological studies revealed specific damage to the vestibular endorgans. In the ipsilateral spinal vestibular nucleus, the medial vestibular nucleus, and the contralateral prepositus hypoglossal nucleus, a substantial number of c-Fos-immunoreactive cells appeared by 1 day after surgery with arsanilic acid, with a maximum increase in number by 2 days and complete disappearance by 7 days. Taken together, these findings indicate that chemical labyrinthectomy with arsanilic acid and the subsequent observation of vestibular compensation is a useful strategy for elucidation of the molecular mechanisms underlying vestibular pathophysiologies.

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Section: Discussionmentioning

confidence: 99%

Vestibular Compensation after Vestibular Dysfunction Induced by Arsanilic Acid in Mice

et al. 2019

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“…This recovery is observed within hours to days following a bilateral labyrinthectomy, which is probably compensated for by the integration of nonlabyrinthic information at the vestibular nucleus level through visual and proprioceptive inputs at the vestibular nucleus [see review in (40)]. Neurogenesis in vestibular nuclei has been demonstrated after unilateral lesion in cats, which could contribute to vestibular and postural function recovery (34,59). The behavioral/temperature changes could also result from an acute response to inflammation or tissue degeneration.…”

Section: Discussionmentioning

confidence: 99%

Vestibular loss disrupts daily rhythm in rats

Martin

Mauvieux

Bulla

et al. 2015

Journal of Applied Physiology

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Hypergravity disrupts the circadian regulation of temperature (Temp) and locomotor activity (Act) mediated through the vestibular otolithic system in mice. In contrast, we do not know whether the anatomical structures associated with vestibular input are crucial for circadian rhythm regulation at 1 G on Earth. In the present study we observed the effects of bilateral vestibular loss (BVL) on the daily rhythms of Temp and Act in semipigmented rats. Our model of vestibular lesion allowed for selective peripheral hair cell degeneration without any other damage. Rats with BVL exhibited a disruption in their daily rhythms (Temp and Act), which were replaced by a main ultradian period ( Ͻ20 h) for 115.8 Ϯ 68.6 h after vestibular lesion compared with rats in the control group. Daily rhythms of Temp and Act in rats with BVL recovered within 1 wk, probably counterbalanced by photic and other nonphotic time cues. No correlation was found between Temp and Act daily rhythms after vestibular lesion in rats with BVL, suggesting a direct influence of vestibular input on the suprachiasmatic nucleus. Our findings support the hypothesis that the vestibular system has an influence on daily rhythm homeostasis in semipigmented rats on Earth, and raise the question of whether daily rhythms might be altered due to vestibular pathology in humans. vestibular system; biological rhythms; temperature; locomotor activity; rats LOCATED IN THE TEMPORAL BONES, the vestibular system is composed of three semicircular canals that encode head rotation velocity and two otolithic macula that encode linear acceleration and gravity force. The vestibular system is primarily involved in gaze stabilization and postural control (23), but its influence has been expanded to autonomic and bone regulation (11,61,63), spatial learning and memory (5, 6, 56), and spatial orientation and perception of gravitational verticality (37). Studies carried out in environments in which gravity is altered have shown evidence of a possible influence of the vestibular system on hypothalamic circadian function in rats (27) and mice (18,46

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“…Peripheral vestibular disorders may alter the perceived shape and size of the body, alter the experience of owning the body and evoke the experience that the self is strange, unreal and disembodied. Tighilet et al ( 2014 ) describe the consequences of vestibular deafferentation for the cat histaminergic system and show that plasticity of the histamine H 3 receptors supports vestibular compensation.…”

Section: Vestibular Disorders and Compensationmentioning

confidence: 99%

Editorial: The Vestibular System in Cognitive and Memory Processes in Mammalians

Besnard

Lopez

Brandt

et al. 2015

Front. Integr. Neurosci.

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International audienceIn the nineteenth century Pierre–Jean–Marie Flourens (1825) and Ernst Mach described the vestibular system and its peripheral organs while Robert Barany, rewarded by the Nobel prize in 1914, was the first to investigate vestibular disorders with caloric tests making surgical treatments of the vestibular organ possible. Recently, Graf and Klam (2006) have reminded us that this ancient sensory system appeared more than 500 million years ago. Logically its influence would most likely not be restricted to balance reflexes at the brainstem level; it must have also shaped our brain. The vestibular system is the one sensory organ dedicated to gravity perception, which along with light and oxygen served as a motor of evolution. In the 1950s the groups of Otto–Joachim Grüsser in Germany, Wilder Penfield in Canada, and later the group of Alain Berthoz in France, demonstrated in elegant experiments on awake monkey (Guldin and Grüsser, 1998), epileptic patient (Penfield, 1957), and neurologically-normal human (Lobel et al., 1999) the existence of vestibular projections to the cortex and how they combine with visual and proprioceptive information. An increasing number of researchers, often fervent disciples, have built on these findings to produce a spate of publications that have consolidated the evidence for a sense of verticality and three-dimensional body representations within the vestibular cortical areas. In the 1990s Paul Smith and colleagues examined vestibular processing in the hippocampus and its role in spatial memory. Exploring this topic in the rodent (Smith, 1997), they began to elucidate the secrets and the previously silent functions of the vestibular system. These findings led to increasing clarity about how vestibular degeneration may be related to some aspects of dementia (Previc, 2013), psychiatric diseases (Gurvich et al., 2013), and cognitive impairments in the elderly (Bigelow et al., 2015; Semenov et al., 2015). The research by Marianne Dieterich and Thomas Brandt has examined the bilateral organization of multiple multisensory cortical areas and revealed the vestibular dominance of the non-dominant hemisphere (Dieterich et al., 2003). They addressed the following questions: how is one global percept of motion and orientation in space formed, and does this dominance determine the lateralization of brain function such as handedness (Brandt and Dieterich, 2015)? A vestibular contribution to the most crucial aspects of the human sense of self and self-consciousness has recently been highlighted by neurological and neuroscientific investigations: vestibular signals contribute to the experience that the self is located within the boundaries of the body (Blanke et al., 2004; Lopez et al., 2008) and may even be involved in self-other discrimination and interactions (Lenggenhager and Lopez, 2015).In this Frontiers in Integrative Neuroscience Research Topic initiated by Sidney Simon, twenty-four articles highlight recent discoveries in the field of vestibular cognition, including: (1) Ana...

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Plasticity of the histamine H3 receptors after acute vestibular lesion in the adult cat

Cited by 14 publications

References 101 publications

Vestibular Compensation after Vestibular Dysfunction Induced by Arsanilic Acid in Mice

Vestibular Compensation after Vestibular Dysfunction Induced by Arsanilic Acid in Mice

Vestibular loss disrupts daily rhythm in rats

Editorial: The Vestibular System in Cognitive and Memory Processes in Mammalians

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