Plasticity of the electroexcitable membrane of the neuron under conditions of calmodulin blockade

Le, Tsitolovskiĭ

doi:10.1007/bf01186896

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…At the same time, these blockers did not exert a suppressant influence on synaptic transmission in hippocampal nerve ceils which were not subjected to tetanic stimulation. The results of experiments which we carried out previously [5,6], as well as published data [9], suggest that calmodulin apparently does not participate in the command neurons of defense behavior of snails in the development of another type of nonassociative learning, habituation to sensory stimulations. Thus, metabolic processes that are specific for them take place during the development of different habits in the very same cells.…”

mentioning

confidence: 67%

Mechanisms of the development of sensitizations in the snail: The participation of calcium and calmodulin

Nikitin

Самойлов

Kózyrev

1994

Neurosci Behav Physiol

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A single sensitizing exposure led to brief (up to 1 h) and prolonged (several hours) changes in the defense reactions of snails, in the activity of command neurons, as well as in the content of bound calcium in these neurons. The application of the specific calmodulin blocker, W7, or the removal of Ca2+ from the medium bathing the snail's CNS before the sensitizing exposure, exerted a suppressant influence on the development of both the brief and the prolonged behavioral and neuronal effects of sensitization. At the same time, the application of W7 or the removal of Ca2+ following the application of the sensitizing influence did not suppress the development of the prolonged changes in the command neurons. The data obtained make it possible to assume that calmodulin directly participates in the regulation of the membrane and synaptic events leading to the development of the brief effects of sensitization. In addition, it is probably involved in the initiation of the metabolic reactions leading to the occurrence of the prolonged effects; however, it does not take part directly in their manifestation.

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mentioning

confidence: 67%

Mechanisms of the development of sensitizations in the snail: The participation of calcium and calmodulin

Nikitin

Самойлов

Kózyrev

1994

Neurosci Behav Physiol

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“…In the research of L. E. Tsitolovskii [16] concerning the possible role of CM in habituation of the electroexcitable membranes of neurons LPa3 and PPa3 of the garden snail to repeated tactile stimulation, a negative result was obtained. In the research of L. E. Tsitolovskii [16] concerning the possible role of CM in habituation of the electroexcitable membranes of neurons LPa3 and PPa3 of the garden snail to repeated tactile stimulation, a negative result was obtained.…”

Section: Calciummentioning

confidence: 99%

Molecular mechanisms of neuronal plasticity during learning: The role of secondary messengers

Kotlyar

Pivovarov

1990

Neurosci Behav Physiol

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We present published data along with our own results concerning the role of second messengers and their intracellular receptors in molecular mechanisms associated with the plasticity of neurons during learning. The participation of cyclic 3',5'-adenosine monophosphate, cyclic 3',5'-guanosine monophosphate, calcium, calmodulin, and also the metabolic products of inositol phospholipids, inositol-1,4,5-triphosphate, diacylglycerol and the protein kinase C activated by it, arachidonic acid, and the products of its lipoxygenase oxidation during the regulation of neuronal plasticity over the course of prolonged potentiation, sensitization, habituation, and classical associative training are discussed.

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Plasticity of the electroexcitable membrane of the neuron under conditions of calmodulin blockade

Cited by 2 publications

References 3 publications

Mechanisms of the development of sensitizations in the snail: The participation of calcium and calmodulin

Mechanisms of the development of sensitizations in the snail: The participation of calcium and calmodulin

Molecular mechanisms of neuronal plasticity during learning: The role of secondary messengers

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