Plasticity of postsynaptic nanostructure

Droogers, Wouter J; MacGillavry, Harold D.

doi:10.1016/j.mcn.2023.103819

Cited by 11 publications

(7 citation statements)

References 129 publications

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“…However, this initial increase may be mediated by a reorganization of synaptic AMPAr and a targeting with presynaptic release sites without a change in number of AMPAr. 30 In essence, the essential characteristics of LTP formation cannot be explained only by changes AMPA receptor number.…”

Section: Discussionmentioning

confidence: 99%

Pre- and postsynaptic nanostructures increase in size and complexity after induction of long-term potentiation

Clavet-Fournier,

Lee,

Wegner

et al. 2024

iScience

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Section: Discussionmentioning

confidence: 99%

Pre- and postsynaptic nanostructures increase in size and complexity after induction of long-term potentiation

Clavet-Fournier,

Lee,

Wegner

et al. 2024

iScience

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“…The PSD of synapses is a wide range of scaffolding proteins, receptors, and signaling molecules that acts as a switchboard of neurotransmitter molecular and have strong association to ASD. 97,98 Glutamate receptor levels could be regulated by endocytosis of PSD scaffolding proteins. 99 In general, E/I balance required the integrity of PSD to transmit signal between neuros.…”

Section: Essential Role Of Postsynaptic Density In Neural Communicationmentioning

confidence: 99%

Autism spectrum disorder: pathogenesis, biomarker, and intervention therapy

Zhuang,

Liang,

et al. 2024

MedComm

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Autism spectrum disorder (ASD) has become a common neurodevelopmental disorder. The heterogeneity of ASD poses great challenges for its research and clinical translation. On the basis of reviewing the heterogeneity of ASD, this review systematically summarized the current status and progress of pathogenesis, diagnostic markers, and interventions for ASD. We provided an overview of the ASD molecular mechanisms identified by multi‐omics studies and convergent mechanism in different genetic backgrounds. The comorbidities, mechanisms associated with important physiological and metabolic abnormalities (i.e., inflammation, immunity, oxidative stress, and mitochondrial dysfunction), and gut microbial disorder in ASD were reviewed. The non‐targeted omics and targeting studies of diagnostic markers for ASD were also reviewed. Moreover, we summarized the progress and methods of behavioral and educational interventions, intervention methods related to technological devices, and research on medical interventions and potential drug targets. This review highlighted the application of high‐throughput omics methods in ASD research and emphasized the importance of seeking homogeneity from heterogeneity and exploring the convergence of disease mechanisms, biomarkers, and intervention approaches, and proposes that taking into account individuality and commonality may be the key to achieve accurate diagnosis and treatment of ASD.

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“…by altering the number of SVs being produced [3] . Postsynaptic modes of regulating signal efficacy have also been described, for example changes in the amount of postsynaptic transmitter receptors and their interaction with scaffolding proteins, membrane resistance or other modes of excitability, like upregulation of voltage-gated ion channels [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Neuropeptidergic regulation of neuromuscular signaling in larval zebrafish alters swimming behavior and synaptic transmission

Dill,

Liewald,

Becker

et al. 2024

Preprint

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The regulation of synaptic transmission is crucial for plasticity, homeostasis and learning. Chemical synaptic transmission is thus modulated to accommodate different activity levels, which also enables homeostatic scaling in pre- and postsynaptic compartments. In nematodes, cAMP signaling enhances cholinergic neuron output, and these neurons use neuropeptide signaling to modulate synaptic vesicle content. To explore if this mechanism is conserved in vertebrates, we studied the involvement of neuropeptides in cholinergic transmission at the neuromuscular junction of larval zebrafish. Optogenetic stimulation by photoactivated adenylyl cyclase (bPAC) resulted in elevated locomotion as measured in behavioural assays. Furthermore, post-synaptic patch-clamp recordings revealed that in bPAC transgenics, the frequency of miniature excitatory postsynaptic currents (mEPSCs) was increased after photostimulation. These results suggested that cAMP-mediated activation of ZF motor neurons leads to increased fusion of SVs, consequently resulting in enhanced neuromuscular activity. We generated mutants lacking the neuropeptide processing enzyme carboxypeptidase E (cpe), and the most abundant neuropeptide precursor in motor neurons, tachykinin (tac1). Both mutants showed exaggerated locomotion after photostimulation. cpe mutants exhibit lower mEPSC frequency during photostimulation and less large-amplitude mEPSCs. In tac1 mutants mEPSC frequency was not affected but amplitudes were significantly smaller. Exaggerated locomotion in the mutants thus reflected upscaling of postsynaptic excitability. cpe and tac1 mutant muscles expressed more nicotinic acetylcholine receptors (nAChR) on their surface. Thus, neuropeptide signaling regulates synaptic transmitter output in zebrafish motor neurons, and muscle cells homeostatically regulate nAChR surface expression, compensating reduced presynaptic input. This mechanism may be widely conserved in the animal kingdom.

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Plasticity of postsynaptic nanostructure

Cited by 11 publications

References 129 publications

Pre- and postsynaptic nanostructures increase in size and complexity after induction of long-term potentiation

Pre- and postsynaptic nanostructures increase in size and complexity after induction of long-term potentiation

Autism spectrum disorder: pathogenesis, biomarker, and intervention therapy

Neuropeptidergic regulation of neuromuscular signaling in larval zebrafish alters swimming behavior and synaptic transmission

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