Plasticity in the superior collicular auditory space map of adult guinea‐pigs

Dj, Withington; Binns, K. E.; Nj, Ingham; Sk, Thornton

doi:10.1113/expphysiol.1994.sp003767

Cited by 17 publications

(9 citation statements)

References 18 publications

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“…However, the SC auditory space map is unaffected by auditory deprivation from 100 days after birth. The data presented here parallel the auditory deprivation study in that both deterioration and repair of the auditory space map were observed post-crucially, but the data from the group visually deprived at 100 days after birth indicate that visual experience is still required for maintenance of a normal map well beyond 100 days after birth (see also Withington et al 1994). The time course of the influence of auditory deprivation on the SC map is closely correlated to the time course of head growth in this species.…”

Section: Discussionsupporting

confidence: 77%

Post‐crucial period effects of visual experience and deprivation on the guinea‐pig superior collicular map of auditory space

Dj¹,

Ke²,

Mj³

et al. 1994

Experimental Physiology

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SUMMARYThere were two primary aims of this study. First, to observe if the map of auditory space in the superior colliculus (SC) of the guinea-pig could recover after periods of normal visual experience following visual deprivation during the crucial period. Second, to determine whether any degradation of the space map was observed when the animal was visually deprived for different lengths of time after the crucial period. Animals deprived of visual experience during the crucial period and then allowed normal experience did show a limited ability to construct a SC auditory space map. Whereas visual deprivation following normal auditory and visual experience during the crucial period caused a profound degradation, of both spatial tuning and topography, of auditory receptive fields in the SC. Additional data indicate that the SC auditory space map remains vulnerable to visual deprivation until at least 100 days after birth.

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Section: Discussionsupporting

confidence: 77%

Post‐crucial period effects of visual experience and deprivation on the guinea‐pig superior collicular map of auditory space

Dj¹,

Ke²,

Mj³

et al. 1994

Experimental Physiology

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“…The answer may lie in the frequency range necessary for each pathway to serve its function. The tectal pathway may represent a fast system dedicated to orienting behavior, equivalent to the superior collicular system in mammals (Freedman and Sparks 1997;King and Hutchings 1987;Middlebrooks and Knudsen 1984;Withington et al 1994), which discards spectral information for speed and efficiency. The forebrain pathway, however, may be involved in functions that require processing information over a broader frequency range.…”

Section: Discussionmentioning

confidence: 99%

Auditory Spatial Tuning at the Crossroads of the Midbrain and Forebrain

Pérez

Shanbhag

Peña³

2009

Journal of Neurophysiology

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Pérez ML, Shanbhag SJ, Peña JL. Auditory spatial tuning at the crossroads of the midbrain and forebrain. J Neurophysiol 102: 1472-1482, 2009. First published July 1, 2009 doi:10.1152/jn.00400.2009. The barn owl's midbrain and forebrain contain neurons tuned to sound direction. The spatial receptive fields of these neurons result from sensitivity to combinations of interaural time (ITD) and level (ILD) differences over a broad frequency range. While a map of auditory space has been described in the midbrain, no similar topographic representation has been found in the forebrain. The first nuclei that belong exclusively to the forebrain and midbrain pathways are the thalamic nucleus ovoidalis (Ov) and the external nucleus of the inferior colliculus (ICx), respectively. The midbrain projects to the auditory thalamus before sharp spatial receptive fields emerge; although Ov and ICx receive projections from the same midbrain nuclei, they are not directly connected. We compared the spatial tuning in Ov and ICx. Thalamic neurons respond to a broader frequency range and their ITD and ILD tuning varied more across frequency. However, neurons in Ov showed spatial receptive fields as selective as neurons in ICx. Thalamic spatial receptive fields were tuned to frontal and contralateral space and correlated with their tuning to ITD and ILD. Our results indicate that spatial tuning emerges in both pathways by similar combination selectivity to ITD and ILD. However, the midbrain and the thalamus do not appear to repeat exactly the same processing, as indicated by the difference in frequency range and the broader tuning to binaural cues. The differences observed at the initial stages of these soundlocalization pathways may reflect diverse functions and coding schemes of midbrain and forebrain.

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“…The potential for plastic reactions of the adult auditory system to an altered input is mostly attributed to the rostral, or higher, auditory structures, particularly the auditory cortex (Scheich, 1991;Weinberger, 1993;Willott et al, 1993;Ahissar and Ahissar, 1994), the medial geniculate body (Edeline and Weinberger, 1991), and the superior colliculus (King and Moore, 1991;Withington et al, 1994). Some studies, however, have already documented that auditory brainstem nuclei also have a potential for plastic reconstructions of neuronal architecture even in the adult brain.…”

Section: Evidence For Plasticity In the Adult Auditory Brainstemmentioning

confidence: 99%

Plasticity of the auditory brainstem: Effects of cochlear ablation on GAP-43 immunoreactivity in the rat

1997

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In the adult brain, expression of the growth associated protein GAP-43 may serve as an indicator of synaptic remodeling. We have studied localization and time course of the re-expression of GAP-43 following deafening through cochlear ablation. As a consequence of unilateral cochlear lesioning, a substantial increase in the expression of GAP-43 was observed in the neuropil of all subnuclei of the ipsilateral cochlear nuclear complex. This expression of GAP-43 occurred in well-defined fibers and boutons. In the ventral cochlear nuclei, boutons immunoreactive for GAP-43 were often localized on cell bodies. However, they were found only on selected subpopulations of cochlear nucleus neurons, i.e., on cell bodies containing glutamate or calretinin immunoreactivity, but apparently not on GABAergic neurons. Olivocochlear neurons must have been axotomized by the operation. Following cochlear ablation, a dramatic re-expression of GAP-43 occurred in cell bodies of the ipsilateral lateral superior olive but not in the ventral nucleus of the trapezoid body. Position and number of these cells suggested that most, if not all, of them serve the lateral olivocochlear bundle. However, although axon collaterals are given off by certain types of olivocochlear neurons, a direct involvement of the immunoreactive cell bodies in the emergence of GAP-43 in the cochlear nucleus is not obvious. A transient rise of GAP-43 immunoreactivity that could not be attributed to axotomized neurons was observed in the contralateral dorsal cochlear nucleus and in the ipsilateral inferior colliculus. Given the functional significance attributed to GAP-43, we conclude that the sudden loss of spiral ganglion cells leads to a reactive synaptogenesis in complex patterns across several auditory brainstem nuclei.

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Plasticity in the superior collicular auditory space map of adult guinea‐pigs

Cited by 17 publications

References 18 publications

Post‐crucial period effects of visual experience and deprivation on the guinea‐pig superior collicular map of auditory space

Post‐crucial period effects of visual experience and deprivation on the guinea‐pig superior collicular map of auditory space

Auditory Spatial Tuning at the Crossroads of the Midbrain and Forebrain

Plasticity of the auditory brainstem: Effects of cochlear ablation on GAP-43 immunoreactivity in the rat

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