Plasticity in the hippocampal formation of shorebirds during the wintering period: Stereological analysis of parvalbumin neurons in Actitis macularius

Guerreiro, Luma Cristina Ferreira; Henrique, Ediely Pereira; Rosa, João Batista da Silva; Pereira, Patrick Douglas Corrêa; Abreu, Cintya Castro de; Fernandes, Taiany Nogueira; Magalhães, Nara Gyzely de Morais; Silva, Anderson de Jesus Falcão da; Costa, Emanuel Ramos da; Guerreiro-Diniz, Cristovam; Diniz, Daniel Guerreiro

doi:10.3758/s13420-021-00473-6

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…Type II, Type III, and Type IV named astrocytes with decreased morphological complexity. We suggest that the differences found between migratory birds' hippocampal astrocyte morphologies might be related to the adaptive response imposed by the contrasting long-distance migratory flights on learning and memory for recognition of olfactory, geomagnetic, and visual cues during migration or to recognize local cues for both migratory birds and non-migratory C. collaris (Mouritsen et al, 2016;Magalhaes et al, 2017;Carvalho-Paulo et al, 2018;da Costa et al, 2020;Henrique et al, 2020;Guerreiro et al, 2021).…”

Section: The Morphological Complexity Of Astrocytes Is Greater In Mig...mentioning

confidence: 89%

Shorebirds’ Longer Migratory Distances Are Associated With Larger ADCYAP1 Microsatellites and Greater Morphological Complexity of Hippocampal Astrocytes

et al. 2022

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For the epic journey of autumn migration, long-distance migratory birds use innate and learned information and follow strict schedules imposed by genetic and epigenetic mechanisms, the details of which remain largely unknown. In addition, bird migration requires integrated action of different multisensory systems for learning and memory, and the hippocampus appears to be the integration center for this task. In previous studies we found that contrasting long-distance migratory flights differentially affected the morphological complexity of two types of hippocampus astrocytes. Recently, a significant association was found between the latitude of the reproductive site and the size of the ADCYAP1 allele in long distance migratory birds. We tested for correlations between astrocyte morphological complexity, migratory distances, and size of the ADCYAP1 allele in three long-distance migrant species of shorebird and one non-migrant. Significant differences among species were found in the number and morphological complexity of the astrocytes, as well as in the size of the microsatellites of the ADCYAP1 gene. We found significant associations between the size of the ADCYAP1 microsatellites, the migratory distances, and the degree of morphological complexity of the astrocytes. We suggest that associations between astrocyte number and morphological complexity, ADCYAP1 microsatellite size, and migratory behavior may be part of the adaptive response to the migratory process of shorebirds.

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Section: The Morphological Complexity Of Astrocytes Is Greater In Mig...mentioning

confidence: 89%

Shorebirds’ Longer Migratory Distances Are Associated With Larger ADCYAP1 Microsatellites and Greater Morphological Complexity of Hippocampal Astrocytes

et al. 2022

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“…Social interaction between birds of the same group may facilitate collective behavior to form ocks and organize ights during migration for energy savings (Ling et al, 2019). Of note, in a previous study we found in a shorebird of the same family (Scolopacidae), a signi cant increase in parvalbuminergic neurons in the hippocampal formation of this species, in the premigratory groups captured in the wintering period, at the same time point and place (Guerreiro et al, 2022). If this observation about the PV neurons of the hippocampal formation extends to C. pusilla, it is reasonable to raise the hypothesis that GABAergic adaptive changes may be required for the spring migratory ight.…”

Section: Discussionmentioning

confidence: 72%

Wintering molecular changes in the brain of Calidris pusilla at lower latitude

Pereira

Henrique

Costa

et al. 2022

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Background: Migrant birds prepare differently to fly north for breeding in spring and for the flight to lower latitudes during autumn avoiding the cold and food shortages of the north hemisphere's harsh winter. The molecular events associated with these fundamental stages in the life history of migrants include the differential gene expression in different tissues. Semipalmated sandpipers (Calidris pusilla) are Artic breeding shorebirds that migrate to the coast of South America during non-breeding season. Thus, the adaptive molecular changes in the brain of these birds at lower latitudes have not yet been investigated in detail. Results: Here, we searched for differential gene expression in the brain of semipalmated sandpiper, of recent arrived birds (RA) from autumnal migration and that of individuals in the premigratory period (PM) in the spring. All individuals were collected in the tropical coastal of northern Brazil. We generated a De novo neurotranscriptome for C. pusilla individuals and compared gene expression across libraries for neurotranscriptome. To that end we mapped RNA-seq reads to the C. pusilla neurotranscriptome in a total of 4 brain samples each group. A total of 266,414 transcripts were reconstructed that yielded 615 differentially expressed genes in the brain of both groups. Conclusions: The present report revealed a remarkable differential gene expression in the brain of recently arrived and premigratory individuals. It also revealed molecular brain changes associated with the recovering of the 4 to 5 days long-distance uninterrupted flight across Atlantic Ocean and preparation for the long-distance multiple stopover spring migration.

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“…Social interaction between birds of the same group may facilitate collective behavior to form flocks and organize flights during the migration for energy savings [ 45 ]. Of note, in a previous study, we found in a shorebird of the same family (Scolopacidae) a significant increase in parvalbuminergic neurons in the hippocampal formation of this species, in the premigratory groups captured in the wintering period, at the same time point and place [ 46 ]. If this observation about the PV neurons of the hippocampal formation extends to C. pusilla , it is reasonable to raise the hypothesis that GABAergic adaptive changes may be required for the spring migratory flight.…”

Section: Discussionmentioning

confidence: 99%

Molecular Changes in the Brain of the Wintering Calidris pusilla in the Mangroves of the Amazon River Estuary

Pereira

Henrique

Costa

et al. 2023

IJMS

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Migrant birds prepare differently to fly north for breeding in the spring and for the flight to lower latitudes during autumn, avoiding the cold and food shortages of the Northern Hemisphere’s harsh winter. The molecular events associated with these fundamental stages in the life history of migrants include the differential gene expression in different tissues. Semipalmated sandpipers (Calidris pusilla) are Arctic-breeding shorebirds that migrate to the coast of South America during the non-breeding season. In a previous study, we demonstrated that between the beginning and the end of the wintering period, substantial glial changes and neurogenesis occur in the brain of C. pusilla. These changes follow the epic journey of the autumn migration when a 5-day non-stop transatlantic flight towards the coast of South America and the subsequent preparation for the long-distance flight of the spring migration takes place. Here, we tested the hypothesis that the differential gene expressions observed in the brains of individuals captured in the autumn and spring windows are consistent with the previously described cellular changes. We searched for differential gene expressions in the brain of the semipalmated sandpiper, of recently arrived birds (RA) from the autumnal migration, and that of individuals in the premigratory period (PM) in the spring. All individuals were collected in the tropical coastal of northern Brazil in the mangrove region of the Amazon River estuary. We generated a de novo neurotranscriptome for C. pusilla individuals and compared the gene expressions across libraries. To that end, we mapped an RNA-Seq that reads to the C. pusilla neurotranscriptome in four brain samples of each group and found that the differential gene expressions in newly arrived and premigratory birds were related with neurogenesis, metabolic pathways (ketone body biosynthetic and the catabolic and lipid biosynthetic processes), and glial changes (astrocyte-dopaminergic neuron signaling, astrocyte differentiation, astrocyte cell migration, and astrocyte activation involved in immune response), as well as genes related to the immune response to virus infections (Type I Interferons), inflammatory cytokines (IL-6, IL-1β, TNF, and NF-κB), NLRP3 inflammasome, anti-inflammatory cytokines (IL-10), and cell death pathways (pyroptosis- and caspase-related changes).

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Plasticity in the hippocampal formation of shorebirds during the wintering period: Stereological analysis of parvalbumin neurons in Actitis macularius

Cited by 3 publications

References 38 publications

Shorebirds’ Longer Migratory Distances Are Associated With Larger ADCYAP1 Microsatellites and Greater Morphological Complexity of Hippocampal Astrocytes

Shorebirds’ Longer Migratory Distances Are Associated With Larger ADCYAP1 Microsatellites and Greater Morphological Complexity of Hippocampal Astrocytes

Wintering molecular changes in the brain of Calidris pusilla at lower latitude

Molecular Changes in the Brain of the Wintering Calidris pusilla in the Mangroves of the Amazon River Estuary

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