Plasticity in neurological disorders and challenges for noninvasive brain stimulation (NBS)

Thickbroom, Gary; Mastaglia, Frank

doi:10.1186/1743-0003-6-4

Cited by 31 publications

(15 citation statements)

References 49 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While neural plasticity contributes significantly to functional recovery, it should be noted that not all types are beneficial. For example, maladaptive plasticity and inappropriate axonal sprouting can lead to spasticity, pathological pain, schizophrenia, and seizures (Dimitrijevi and Nathan, 1967; Flor et al, 1995; Teyler et al, 2001; Quartarone et al, 2008; Thickbroom and Mastaglia, 2009; Kuner, 2010; Hasan et al, 2011). …”

Section: The Physiology Of Recovery From Neurological Injurymentioning

confidence: 99%

Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation

et al. 2016

View full text Add to dashboard Cite

After an initial period of recovery, human neurological injury has long been thought to be static. In order to improve quality of life for those suffering from stroke, spinal cord injury, or traumatic brain injury, researchers have been working to restore the nervous system and reduce neurological deficits through a number of mechanisms. For example, neurobiologists have been identifying and manipulating components of the intra- and extracellular milieu to alter the regenerative potential of neurons, neuro-engineers have been producing brain-machine and neural interfaces that circumvent lesions to restore functionality, and neurorehabilitation experts have been developing new ways to revitalize the nervous system even in chronic disease. While each of these areas holds promise, their individual paths to clinical relevance remain difficult. Nonetheless, these methods are now able to synergistically enhance recovery of native motor function to levels which were previously believed to be impossible. Furthermore, such recovery can even persist after training, and for the first time there is evidence of functional axonal regrowth and rewiring in the central nervous system of animal models. To attain this type of regeneration, rehabilitation paradigms that pair cortically-based intent with activation of affected circuits and positive neurofeedback appear to be required—a phenomenon which raises new and far reaching questions about the underlying relationship between conscious action and neural repair. For this reason, we argue that multi-modal therapy will be necessary to facilitate a truly robust recovery, and that the success of investigational microscopic techniques may depend on their integration into macroscopic frameworks that include task-based neurorehabilitation. We further identify critical components of future neural repair strategies and explore the most updated knowledge, progress, and challenges in the fields of cellular neuronal repair, neural interfacing, and neurorehabilitation, all with the goal of better understanding neurological injury and how to improve recovery.

show abstract

Section: The Physiology Of Recovery From Neurological Injurymentioning

confidence: 99%

Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Brain plasticity may be neuronal or nonneuronal, and the former may be synaptic or non‐synaptic (37). Thus, modulation of synaptic transmission (38) is only one of many mechanisms of brain plasticity (39).…”

Section: Subacute and Chronic Changes After Tbimentioning

confidence: 99%

Noninvasive Brain Stimulation to Modulate Neuroplasticity in Traumatic Brain Injury

Villamar

Portilla

Fregni

et al. 2012

Neuromodulation: Technology at the Neural Interface

101

View full text Add to dashboard Cite

“…Other variables, such as intensity of current, stimulated area, stimulation time and methods used to measure the outcomes were similar, corroborating with protocols used by other authors in different populations that investigated the same outcomes (19,20) . It is known that after stroke may occur a change in synaptic homeostasis, which affects individuals' cognition (21) . In the present study the verbal and visual WM showed significant improvements after the use of tDCS, supporting the results found in diverse population by other authors (22,23) .…”

Section: Discussionmentioning

confidence: 99%

Effects of transcranial direct current stimulation on the working memory of post-stroke people: an integrative review

Silva-Filho¹,

Albuquerque²,

Mescouto³

et al. 2020

mtprehabjournal

View full text Add to dashboard Cite

Background: Stroke is a chronic disease that is becoming more common in all the world causing damage to people affected, for instance, cognitive deficits. The Transcranial Direct Current Stimulation (tDCS) is a form of treatment that modulates specific areas of the nervous system. Objective: The objective of this integrative review was to analyze the effectiveness of Transcranial Direct Current Stimulation (tDCS) on the working memory (WM) in post-stroke patients. Method: This review included articles that analyzed the effects of tDCS on human beings with a diagnosis of stroke and used as outcomes: verbal, visual, spatial or auditory WM. The assessment of studies elegibility was performed by two independent researchers from 8 databases: Cochrane Library via Wiley -CENTRAL, PubMed, LILACS, SCIELO, Web of Science, Scopus, CINAHL and PEDro following PRISMA guideline. Results: Three articles were included in the qualitative synthesis presenting a total of 66 participants (32 male and 34 female), 36 ischemic stroke and 30 hemorrhagic stroke with an average time of 42 days. Interventions were done on the areas F3/F4 (dorsolateral part of the prefrontal cortex) and T3/T4 (temporal anterior lobe) with 2mA current intensity for 30 minutes duration. The outcomes analyzed: verbal, visual, spatial, and auditory WM showed significant improvements after the use of tDCS. Conclusion: The limitations of this review were study designs, number of participants, lack of standardized interventions and short period of follow-up. tDCS showed satisfactory results on the WM of post-stroke individuals, but it is needed to be cautious due to the methodological quality of the articles. It is registered in the Prospective Register of Systematic Reviews -PROSPERO with registration number CDR42016048050.

show abstract

Plasticity in neurological disorders and challenges for noninvasive brain stimulation (NBS)

Cited by 31 publications

References 49 publications

Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation

Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation

Noninvasive Brain Stimulation to Modulate Neuroplasticity in Traumatic Brain Injury

Effects of transcranial direct current stimulation on the working memory of post-stroke people: an integrative review

Contact Info

Product

Resources

About